| Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species XQ Chen, WC Mobley Frontiers in neuroscience 13 (659), 2019 | 277 | 2019 |
| Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses XQ Chen, WC Mobley Frontiers in neuroscience 13 (446), 2019 | 168 | 2019 |
| Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy Z Mo, X Zhao, H Liu, Q Hu, XQ Chen, J Pham, N Wei, Z Liu, J Zhou, ... Nature communications 9 (1), 1007, 2018 | 105 | 2018 |
| TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease X Zhao, XQ Chen, E Han, Y Hu, P Paik, Z Ding, J Overman, AL Lau, ... Proceedings of the National Academy of Sciences 113 (38), E5655-E5664, 2016 | 98 | 2016 |
| The Role of TGF-β and Its Receptors in Gastrointestinal Cancers J Luo, XQ Chen, P Li Translational Oncology 12 (3), 475-484, 2019 | 96 | 2019 |
| Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease F Fang, W Yang, JB Florio, E Rockenstein, B Spencer, XM Orain, ... Scientific reports 7 (1), 3868, 2017 | 89 | 2017 |
| Dysregulation of Neurotrophin Signaling in the Pathogenesis of Alzheimer Disease and of Alzheimer Disease in Down Syndrome XQ Chen, M Sawa, WC Mobley Free Radical Biology and Medicine 114, 52-61, 2018 | 62 | 2018 |
| Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons XQ Chen, B Wang, C Wu, J Pan, B Yuan, YY Su, XY Jiang, X Zhang, ... Cell research 22 (4), 677-696, 2012 | 48 | 2012 |
| Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model XQ Chen, A Salehi, ML Pearn, C Overk, PD Nguyen, AM Kleschevnikov, ... Alzheimer's & dementia: the journal of the Alzheimer's Association 17 (2 …, 2021 | 38 | 2021 |
| T‐complex protein 1‐ring complex enhances retrograde axonal transport by modulating tau phosphorylation XQ Chen, F Fang, JB Florio, E Rockenstein, E Masliah, WC Mobley, ... Traffic 19 (11), 840-853, 2018 | 27 | 2018 |
| CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor XQ Chen, JX Zhu, Y Wang, X Zhang, L Bao Journal of molecular cell biology 6 (2), 140-153, 2014 | 21 | 2014 |
| Mechanistic analysis of age-related clinical manifestations in Down syndrome XQ Chen, Z Xing, QD Chen, RJ Salvi, X Zhang, B Tycko, WC Mobley, ... Frontiers in Aging Neuroscience 13, 700280, 2021 | 18 | 2021 |
| Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport XQ Chen, D Utpal, P Goonho, WC Mobley Alzheimer's Research & Therapy 13 (1), 59, 2021 | 15 | 2021 |
| Clinical Opioids Differentially Induce Co-Internalization of μ-and δ-Opioid Receptors F Bao, CL Li, XQ Chen, YJ Lu, L Bao, X Zhang Molecular Pain 14, 1-15, 2018 | 11 | 2018 |
| Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer’s disease and the Dp16 mouse Down syndrome model: impact of APP gene dose XQ Chen, X Zuo, A Becker, E Head, WC Mobley Alzheimer's & dementia: the journal of the Alzheimer's Association 19 (5 …, 2023 | 9 | 2023 |
| Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression XQ Chen, CA Barrero, VD Carpio, EP Reddy, C Fecchio, S Merali, ... Pharmaceutics 13 (12), 2109, 2021 | 6 | 2021 |
| Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation XQ Chen Neural Regeneration Research 14 (4), 588-590, 2019 | 5 | 2019 |
| A pilot exploration with Posiphen to normalize amyloid precursor protein in Down syndrome XQ Chen Neural Regeneration Research 16 (12), 2420-2421, 2021 | 4 | 2021 |
| Calcium-sensing receptor bridges calcium and telomerase reverse transcriptase in gastric cancers via Akt R Xie, B Tuo, S Yang, XQ Chen, J Xu Clinical and Translational Oncology 20, 1023-1032, 2020 | 4 | 2020 |
| Retromer proteins reduced in Down syndrome and the Dp16 model: impact of APP dose and preclinical studies of a γ-secretase modulator XQ Chen, M Sawa, A Becker, D Karachentsev, X Zuo, KD Rynearson, ... Annals of Neurology 94 (2), 245-258, 2023 | 3 | 2023 |
