| A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib) relationships among protein conformation, inhibitor off-rate, and receptor activity in … ER Wood, AT Truesdale, OB McDonald, D Yuan, A Hassell, SH Dickerson, ... Cancer research 64 (18), 6652-6659, 2004 | 1372 | 2004 |
| Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and … JM Axten, JR Medina, Y Feng, A Shu, SP Romeril, SW Grant, WHH Li, ... Journal of medicinal chemistry 55 (16), 7193-7207, 2012 | 696 | 2012 |
| Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin-and DNA-binding domains. KP Wilson, LM Shewchuk, RG Brennan, AJ Otsuka, BW Matthews Proceedings of the National Academy of Sciences 89 (19), 9257-9261, 1992 | 367 | 1992 |
| Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis HN Bramson, J Corona, ST Davis, SH Dickerson, M Edelstein, SV Frye, ... Journal of medicinal chemistry 44 (25), 4339-4358, 2001 | 318 | 2001 |
| The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway KD Baker, LM Shewchuk, T Kozlova, M Makishima, A Hassell, B Wisely, ... Cell 113 (6), 731-742, 2003 | 293 | 2003 |
| Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 … L Shewchuk, A Hassell, B Wisely, W Rocque, W Holmes, J Veal, ... Journal of medicinal chemistry 43 (1), 133-138, 2000 | 274 | 2000 |
| Crystallization of protein–ligand complexes AM Hassell, G An, RK Bledsoe, JM Bynum, HL Carter, SJJ Deng, ... Acta Crystallographica Section D: Biological Crystallography 63 (1), 72-79, 2007 | 252 | 2007 |
| Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors ST Davis, BG Benson, HN Bramson, DE Chapman, SH Dickerson, ... Science 291 (5501), 134-137, 2001 | 248 | 2001 |
| Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail LM Shewchuk, AM Hassell, B Ellis, WD Holmes, R Davis, EL Horne, ... Structure 8 (11), 1105-1113, 2000 | 192 | 2000 |
| X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor− ligand binding domain K Biggadike, RK Bledsoe, AM Hassell, BE Kirk, IM McLay, LM Shewchuk, ... Journal of medicinal chemistry 51 (12), 3349-3352, 2008 | 141 | 2008 |
| 6-Ethynylthieno [3, 2-d]-and 6-ethynylthieno [2, 3-d] pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases ER Wood, LM Shewchuk, B Ellis, P Brignola, RL Brashear, TR Caferro, ... Proceedings of the National Academy of Sciences 105 (8), 2773-2778, 2008 | 139 | 2008 |
| Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts CT Walsh, MD Distefano, MJ Moore, LM Shewchuk, GL Verdine The FASEB journal 2 (2), 124-130, 1988 | 139 | 1988 |
| Peptide ligands of pp60c-src SH2 domains: a thermodynamic and structural study PS Charifson, LM Shewchuk, W Rocque, CW Hummel, SR Jordan, ... Biochemistry 36 (21), 6283-6293, 1997 | 127 | 1997 |
| Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors TR Rheault, TR Caferro, SH Dickerson, KH Donaldson, MD Gaul, ... Bioorganic & medicinal chemistry letters 19 (3), 817-820, 2009 | 105 | 2009 |
| Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib TM Gilmer, L Cable, K Alligood, D Rusnak, G Spehar, KT Gallagher, ... Cancer research 68 (2), 571-579, 2008 | 90 | 2008 |
| Transcriptional switching by the metalloregulatory MerR protein: initial characterization of DNA and mercury (II) binding activities LM Shewchuk, GL Verdine, CT Walsh Biochemistry 28 (5), 2331-2339, 1989 | 87 | 1989 |
| Optimization of 4, 6-bis-anilino-1H-pyrrolo [2, 3-d] pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity SD Chamberlain, AM Redman, JW Wilson, F Deanda, JB Shotwell, ... Bioorganic & medicinal chemistry letters 19 (2), 360-364, 2009 | 75 | 2009 |
| Discovery of 1-(1, 3, 5-triazin-2-yl) piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase RK Thalji, JJ McAtee, S Belyanskaya, M Brandt, GD Brown, MH Costell, ... Bioorganic & medicinal chemistry letters 23 (12), 3584-3588, 2013 | 71 | 2013 |
| Prediction of multiple binding modes of the CDK2 inhibitors, anilinopyrazoles, using the automated docking programs GOLD, FlexX, and LigandFit: an evaluation of performance H Sato, LM Shewchuk, J Tang Journal of chemical information and modeling 46 (6), 2552-2562, 2006 | 70 | 2006 |
| Transcriptional switching by the MerR protein: activation and repression mutants implicate distinct DNA and mercury (II) binding domains LM Shewchuk, JD Helmann, W Ross, SJ Park, AO Summers, CT Walsh Biochemistry 28 (5), 2340-2344, 1989 | 68 | 1989 |
