| The role of dynamic conformational ensembles in biomolecular recognition DD Boehr, R Nussinov, PE Wright Nature chemical biology 5 (11), 789-796, 2009 | 2032 | 2009 |
| The dynamic energy landscape of dihydrofolate reductase catalysis DD Boehr, D McElheny, HJ Dyson, PE Wright science 313 (5793), 1638-1642, 2006 | 1075 | 2006 |
| An NMR perspective on enzyme dynamics DD Boehr, HJ Dyson, PE Wright Chemical reviews 106 (8), 3055-3079, 2006 | 588 | 2006 |
| How do proteins interact? DD Boehr, PE Wright Science 320 (5882), 1429-1430, 2008 | 225 | 2008 |
| Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes SJ Sucheck, AL Wong, KM Koeller, DD Boehr, K Draker, P Sears, ... Journal of the American Chemical Society 122 (21), 5230-5231, 2000 | 176 | 2000 |
| Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands DD Boehr, D McElheny, HJ Dyson, PE Wright Proceedings of the National Academy of Sciences 107 (4), 1373-1378, 2010 | 162 | 2010 |
| Analysis of the π-π stacking interactions between the aminoglycoside antibiotic kinase APH (3′)-IIIa and its nucleotide ligands DD Boehr, AR Farley, GD Wright, JR Cox Chemistry & biology 9 (11), 1209-1217, 2002 | 128 | 2002 |
| Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes DD Boehr, K Draker, K Koteva, M Bains, RE Hancock, GD Wright Chemistry & biology 10 (2), 189-196, 2003 | 115 | 2003 |
| A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase DD Boehr, JR Schnell, D McElheny, SH Bae, BM Duggan, SJ Benkovic, ... Biochemistry 52 (27), 4605-4619, 2013 | 92 | 2013 |
| Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition X Yang, ED Smidansky, KR Maksimchuk, D Lum, JL Welch, JJ Arnold, ... Structure 20 (9), 1519-1527, 2012 | 92 | 2012 |
| Molecular mechanism of aminoglycoside antibiotic kinase APH (3′)-IIIa: roles of conserved active site residues DD Boehr, PR Thompson, GD Wright Journal of Biological Chemistry 276 (26), 23929-23936, 2001 | 81 | 2001 |
| Domain− Domain Interactions in the Aminoglycoside Antibiotic Resistance Enzyme AAC (6 ‘)-APH (2 ‘‘) DD Boehr, DM Daigle, GD Wright Biochemistry 43 (30), 9846-9855, 2004 | 76 | 2004 |
| The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family L Van Der Linden, L Vives-Adrián, B Selisko, C Ferrer-Orta, X Liu, ... PLoS pathogens 11 (3), e1004733, 2015 | 68 | 2015 |
| Biophysical and computational methods to analyze amino acid interaction networks in proteins KF O'Rourke, SD Gorman, DD Boehr Computational and structural biotechnology journal 14, 245-251, 2016 | 65 | 2016 |
| Mechanism of aminoglycoside antibiotic kinase APH (3 ‘)-IIIa: role of the nucleotide positioning loop PR Thompson, DD Boehr, AM Berghuis, GD Wright Biochemistry 41 (22), 7001-7007, 2002 | 62 | 2002 |
| Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis DD Boehr, HJ Dyson, PE Wright Biochemistry 47 (35), 9227-9233, 2008 | 61 | 2008 |
| Amino Acid Networks in a (β/α)8 Barrel Enzyme Change during Catalytic Turnover JM Axe, EM Yezdimer, KF O’Rourke, NE Kerstetter, W You, CA Chang, ... Journal of the American Chemical Society 136 (19), 6818-6821, 2014 | 55 | 2014 |
| Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance X Yang, JL Welch, JJ Arnold, DD Boehr Biochemistry 49 (43), 9361-9371, 2010 | 54 | 2010 |
| Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity X Liu, X Yang, CA Lee, IM Moustafa, ED Smidansky, D Lum, JJ Arnold, ... Journal of Biological Chemistry 288 (45), 32753-32765, 2013 | 50 | 2013 |
| Engineered control of enzyme structural dynamics and function DD Boehr, RN D'Amico, KF O'Rourke Protein Science 27 (4), 825-838, 2018 | 44 | 2018 |
