Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae L Viladevall, R Serrano, A Ruiz, G Domenech, J Giraldo, A Barceló, ... Journal of Biological Chemistry 279 (42), 43614-43624, 2004 | 247 | 2004 |
Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization L Romero, D Zamanillo, X Nadal, R Sánchez‐Arroyos, I Rivera‐Arconada, ... British journal of pharmacology 166 (8), 2289-2306, 2012 | 209 | 2012 |
Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling AM Briones, JM González, B Somoza, J Giraldo, CJ Daly, E Vila, ... The Journal of physiology 552 (1), 185-195, 2003 | 180 | 2003 |
An allosteric modulator to control endogenous G protein-coupled receptors with light S Pittolo, X Gomez-Santacana, K Eckelt, X Rovira, J Dalton, C Goudet, ... Nature chemical biology 10 (10), 813-815, 2014 | 174 | 2014 |
Assessing the (a) symmetry of concentration-effect curves: empirical versus mechanistic models J Giraldo, NM Vivas, E Vila, A Badia Pharmacology & therapeutics 95 (1), 21-45, 2002 | 151 | 2002 |
Chromosomal instability in amniocytes from fetuses of mothers who smoke RA De La Chica, I Ribas, J Giraldo, J Egozcue, C Fuster Jama 293 (10), 1212-1222, 2005 | 127 | 2005 |
Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats A Fisas, X Codony, G Romero, A Dordal, J Giraldo, R Mercé, J Holenz, ... British journal of pharmacology 148 (7), 973, 2006 | 109 | 2006 |
Increased superoxide anion production by interleukin-1β impairs nitric oxide-mediated relaxation in resistance arteries F Jiménez-Altayó, AM Briones, J Giraldo, AM Planas, M Salaices, E Vila Journal of pharmacology and Experimental Therapeutics 316 (1), 42-52, 2006 | 92 | 2006 |
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways X Rovira, JP Pin, J Giraldo Trends in pharmacological sciences 31 (1), 15-21, 2010 | 87 | 2010 |
Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells D Moreno Delgado, TC Møller, J Ster, J Giraldo, D Maurel, X Rovira, ... Elife 6, e25233, 2017 | 82 | 2017 |
OptoGluNAM4. 1, a photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity X Rovira, A Trapero, S Pittolo, C Zussy, A Faucherre, C Jopling, J Giraldo, ... Cell chemical biology 23 (8), 929-934, 2016 | 82 | 2016 |
Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine2A receptor homodimers J Brea, M Castro, J Giraldo, JF Lopez-Gimenez, JF Padín, F Quintian, ... Molecular pharmacology 75 (6), 1380-1391, 2009 | 80 | 2009 |
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals X Gómez-Santacana, S Pittolo, X Rovira, M Lopez, C Zussy, JAR Dalton, ... ACS Central Science 3 (3), 81-91, 2017 | 76 | 2017 |
A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae L Barreto, D Canadell, S Petrezsélyová, C Navarrete, L Marešová, ... Eukaryotic cell 10 (9), 1241-1250, 2011 | 70 | 2011 |
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4 C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, ... Molecular psychiatry 23 (3), 509-520, 2018 | 65 | 2018 |
Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors X Rovira, F Malhaire, P Scholler, J Rodrigo, P Gonzalez‐Bulnes, ... The FASEB Journal 29 (1), 116-130, 2015 | 65 | 2015 |
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator J Font, M Lopez-Cano, S Notartomaso, P Scarselli, P Di Pietro, ... Elife 6, e23545, 2017 | 59 | 2017 |
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer J Liu, Z Zhang, D Moreno-Delgado, JAR Dalton, X Rovira, A Trapero, ... Elife 6, e26985, 2017 | 58 | 2017 |
Advanced age increases chromosome structural abnormalities in human spermatozoa C Templado, A Donate, J Giraldo, M Bosch, A Estop European Journal of Human Genetics 19 (2), 145-151, 2011 | 58 | 2011 |
QSAR and molecular modelling: concepts, computational tools and biological applications F Sanz, J Giraldo, F Manaut | 56 | 1995 |