Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry Y Ho, A Gruhler, A Heilbut, GD Bader, L Moore, SL Adams, A Millar, ... Nature 415 (6868), 180-183, 2002 | 4614 | 2002 |
The CRAPome: a contaminant repository for affinity purification–mass spectrometry data D Mellacheruvu, Z Wright, AL Couzens, JP Lambert, NA St-Denis, T Li, ... Nature methods 10 (8), 730-736, 2013 | 1701 | 2013 |
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome T Bürckstümmer, C Baumann, S Blüml, E Dixit, G Dürnberger, H Jahn, ... Nature immunology 10 (3), 266-272, 2009 | 1250 | 2009 |
Gene essentiality and synthetic lethality in haploid human cells VA Blomen, P Májek, LT Jae, JW Bigenzahn, J Nieuwenhuis, J Staring, ... Science 350 (6264), 1092-1096, 2015 | 869 | 2015 |
Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets U Rix, O Hantschel, G Dürnberger, LL Remsing Rix, M Planyavsky, ... Blood, The Journal of the American Society of Hematology 110 (12), 4055-4063, 2007 | 769 | 2007 |
RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme J Holzmann, P Frank, E Löffler, KL Bennett, C Gerner, W Rossmanith Cell 135 (3), 462-474, 2008 | 700 | 2008 |
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 M Rebsamen, L Pochini, T Stasyk, MEG De Araújo, M Galluccio, ... Nature 519 (7544), 477-481, 2015 | 688 | 2015 |
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress D Weismann, K Hartvigsen, N Lauer, KL Bennett, HPN Scholl, PC Issa, ... Nature 478 (7367), 76-81, 2011 | 589 | 2011 |
IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA A Pichlmair, C Lassnig, CA Eberle, MW Górna, CL Baumann, TR Burkard, ... Nature immunology 12 (7), 624-630, 2011 | 576 | 2011 |
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells T Bürckstümmer, KL Bennett, A Preradovic, G Schütze, O Hantschel, ... Nature methods 3 (12), 1013-1019, 2006 | 475 | 2006 |
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014 | 442 | 2014 |
Artemisinins target GABAA receptor signaling and impair α cell identity J Li, T Casteels, T Frogne, C Ingvorsen, C Honore, M Courtney, ... Cell 168 (1), 86-100. e15, 2017 | 385 | 2017 |
The DEAD‐box helicase DDX3X is a critical component of the TANK‐binding kinase 1‐dependent innate immune response D Soulat, T Bürckstümmer, S Westermayer, A Goncalves, A Bauch, ... The EMBO journal 27 (15), 2135-2146, 2008 | 358 | 2008 |
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib O Hantschel, U Rix, U Schmidt, T Bürckstümmer, M Kneidinger, G Schütze, ... Proceedings of the National Academy of Sciences 104 (33), 13283-13288, 2007 | 346 | 2007 |
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells LL Remsing Rix, U Rix, J Colinge, O Hantschel, KL Bennett, T Stranzl, ... Leukemia 23 (3), 477-485, 2009 | 325 | 2009 |
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer J Li, U Rix, B Fang, Y Bai, A Edwards, J Colinge, KL Bennett, J Gao, ... Nature chemical biology 6 (4), 291-299, 2010 | 313 | 2010 |
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ... Nature chemical biology 11 (8), 571-578, 2015 | 287 | 2015 |
Viral immune modulators perturb the human molecular network by common and unique strategies A Pichlmair, K Kandasamy, G Alvisi, O Mulhern, R Sacco, M Habjan, ... Nature 487 (7408), 486-490, 2012 | 278 | 2012 |
CD14 is a coreceptor of Toll-like receptors 7 and 9 CL Baumann, IM Aspalter, O Sharif, A Pichlmair, S Blüml, F Grebien, ... Journal of Experimental Medicine 207 (12), 2689-2701, 2010 | 273 | 2010 |
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS M Varjosalo, R Sacco, A Stukalov, A Van Drogen, M Planyavsky, S Hauri, ... Nature methods 10 (4), 307-314, 2013 | 230 | 2013 |