Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but … M Fujimura, F Usuki, M Sawada, A Takashima Neurotoxicology 30 (6), 1000-1007, 2009 | 129 | 2009 |
Acute and delayed effects of phencyclidine upon mRNA levels of markers of glutamatergic and GABAergic neurotransmitter function in the rat brain SM Cochran, M Fujimura, BJ Morris, JA Pratt Synapse 46 (3), 206-214, 2002 | 109 | 2002 |
Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure F Usuki, A Yamashita, M Fujimura Journal of Biological Chemistry 286 (8), 6641-6649, 2011 | 92 | 2011 |
The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease … G Griebel, J Stemmelin, M Lopez-Grancha, D Boulay, G Boquet, ... Scientific reports 9 (1), 18045, 2019 | 88 | 2019 |
Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure M Fujimura, F Usuki, M Kawamura, S Izumo Toxicology and applied pharmacology 250 (1), 1-9, 2011 | 80 | 2011 |
Our evolved understanding of the human health risks of mercury N Basu, A Bastiansz, JG Dórea, M Fujimura, M Horvat, E Shroff, P Weihe, ... Ambio 52 (5), 877-896, 2023 | 71 | 2023 |
Effects of dietary methylmercury on the zebrafish brain: histological, mitochondrial, and gene transcription analyses S Cambier, P Gonzalez, N Mesmer-Dudons, D Brèthes, M Fujimura, ... Biometals 25, 165-180, 2012 | 70 | 2012 |
Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons M Fujimura, F Usuki, M Sawada, W Rostene, D Godefroy, A Takashima Neurotoxicology 30 (1), 16-22, 2009 | 70 | 2009 |
Methylmercury causes blood-brain barrier damage in rats via upregulation of vascular endothelial growth factor expression T Takahashi, M Fujimura, M Koyama, M Kanazawa, F Usuki, M Nishizawa, ... PLoS One 12 (1), e0170623, 2017 | 56 | 2017 |
Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project M Esteban, BK Schindler, JA Jiménez, HM Koch, J Angerer, M Rosado, ... Environmental research 141, 24-30, 2015 | 51 | 2015 |
Perinatal exposure to low-dose methylmercury induces dysfunction of motor coordination with decreases in synaptophysin expression in the cerebellar granule cells of rats M Fujimura, J Cheng, W Zhao Brain research 1464, 1-7, 2012 | 51 | 2012 |
Neuropharmacological profile of a novel potential atypical antipsychotic drug Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1] benzothieno [2, 3-b][1, 5] benzodiazepine maleate) T Morimoto, K Hashimoto, H Yasumatsu, H Tanaka, M Fujimura, ... Neuropsychopharmacology 26 (4), 456-467, 2002 | 49 | 2002 |
Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho … M Fujimura, F Usuki Toxicological Sciences 126 (2), 506-514, 2012 | 48 | 2012 |
Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice M Fujimura, F Usuki Toxicology letters 271, 66-73, 2017 | 47 | 2017 |
Methylmercury induces the expression of TNF-α selectively in the brain of mice M Iwai-Shimada, T Takahashi, MS Kim, M Fujimura, H Ito, T Toyama, ... Scientific reports 6 (1), 38294, 2016 | 46 | 2016 |
Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption JP Bourdineaud, M Fujimura, M Laclau, M Sawada, A Yasutake Environment International 37 (2), 303-313, 2011 | 43 | 2011 |
The chemokine CCL2 protects against methylmercury neurotoxicity D Godefroy, RD Gosselin, A Yasutake, M Fujimura, C Combadière, ... Toxicological Sciences 125 (1), 209-218, 2012 | 41 | 2012 |
Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3β and subsequent degradation of … M Fujimura, F Usuki Toxicology and Applied Pharmacology 288 (1), 19-25, 2015 | 40 | 2015 |
Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators M Fujimura, F Usuki Toxicology and Applied Pharmacology 282 (3), 259-266, 2015 | 40 | 2015 |
Methylmercury-mediated oxidative stress and activation of the cellular protective system M Fujimura, F Usuki Antioxidants 9 (10), 1004, 2020 | 39 | 2020 |