Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. SL Kunkel, M Spengler, MA May, R Spengler, J Larrick, D Remick Journal of Biological Chemistry 263 (11), 5380-5384, 1988 | 827 | 1988 |
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline RM Strieter, DG Remick, PA Ward, RN Spengler, JP Lynch Iii, J Larrick, ... Biochemical and biophysical research communications 155 (3), 1230-1236, 1988 | 750 | 1988 |
Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion NG Frangogiannis, ML Lindsey, LH Michael, KA Youker, RB Bressler, ... Circulation 98 (7), 699-710, 1998 | 713 | 1998 |
Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. RN Spengler, RM Allen, DG Remick, RM Strieter, SL Kunkel Journal of immunology (Baltimore, Md.: 1950) 145 (5), 1430-1434, 1990 | 475 | 1990 |
Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro. RN Spengler, SW Chensue, DA Giacherio, N Blenk, SL Kunkel Journal of immunology (Baltimore, Md.: 1950) 152 (6), 3024-3031, 1994 | 335 | 1994 |
Brain-derived TNFα mediates neuropathic pain TA Ignatowski, WC Covey, PR Knight, CM Severin, TJ Nickola, ... Brain Research 841 (1-2), 70-77, 1999 | 221 | 1999 |
The hippocampus and TNF: Common links between chronic pain and depression V Fasick, RN Spengler, S Samankan, ND Nader, TA Ignatowski Neuroscience & Biobehavioral Reviews 53, 139-159, 2015 | 213 | 2015 |
Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy … D Armstrong, AJ Augustin, R Spengler, A Al-Jada, T Nickola, F Grus, ... Ophthalmologica 212 (6), 410-414, 1998 | 171 | 1998 |
Brain-derived TNFα: involvement in neuroplastic changes implicated in the conscious perception of persistent pain WC Covey, TA Ignatowski, PR Knight, RN Spengler Brain research 859 (1), 113-122, 2000 | 160 | 2000 |
Dynamics of dibutyryl cyclic AMP-and prostaglandin E2-mediated suppression of lipopolysaccharide-induced tumor necrosis factor alpha gene expression RN Spengler, ML Spengler, P Lincoln, DG Remick, RM Strieter, ... Infection and immunity 57 (9), 2837-2841, 1989 | 151 | 1989 |
Differential regulation of tumor necrosis factor-alpha in human alveolar macrophages and peripheral blood monocytes: a cellular and molecular analysis RM Strieter, DG Remick, JP Lynch III, M Genord, C Raiford, R Spengler, ... American Journal of Respiratory Cell and Molecular Biology 1 (1), 57-63, 1989 | 115 | 1989 |
Neuronal-associated tumor necrosis factor (TNFα): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration TA Ignatowski, BK Noble, JR Wright, JL Gorfien, RR Heffner, RN Spengler Journal of neuroimmunology 79 (1), 84-90, 1997 | 112 | 1997 |
Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain WC Covey, TA Ignatowski, AE Renauld, PR Knight, ND Nader, ... Regional Anesthesia & Pain Medicine 27 (4), 357-366, 2002 | 98 | 2002 |
Tumor necrosis factor-α: Presynaptic sensitivity is modified after antidepressant drug administration TA Ignatowski, RN Spengler Brain research 665 (2), 293-299, 1994 | 97 | 1994 |
Modulation of tumor necrosis factor-alpha gene expression. Desensitization of prostaglandin E2-induced suppression. RN Spengler, ML Spengler, RM Strieter, DG Remick, JW Larrick, ... Journal of immunology (Baltimore, Md.: 1950) 142 (12), 4346-4350, 1989 | 89 | 1989 |
Temporal regulation by adrenergic receptor stimulation of macrophage (MΦ)-derived tumor necrosis factor (TNF) production post-LPS challenge TA Ignatowski, S Gallant, RN Spengler Journal of neuroimmunology 65 (2), 107-117, 1996 | 77 | 1996 |
Brain-derived tumor necrosis factor-α and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant JL Reynolds, TA Ignatowski, R Sud, RN Spengler Journal of Pharmacology and Experimental Therapeutics 310 (3), 1216-1225, 2004 | 75 | 2004 |
Lipid hydroperoxide stimulates retinal neovascularization in rabbit retina through expression of tumor necrosis factor-a, vascular endothelial growth factor and platelet … D Armstrong, T Ueda, T Ueda, A Aljada, R Browne, S Fukuda, R Spengler, ... Angiogenesis 2, 93-104, 1998 | 74 | 1998 |
Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-α during the perioperative period ND Nader, TA Ignatowski, CJ Kurek, PR Knight, RN Spengler Anesthesia & Analgesia 93 (2), 363-369, 2001 | 70 | 2001 |
Antinociception occurs with a reversal in α2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro-to anti-inflammatory R Sud, RN Spengler, ND Nader, TA Ignatowski European journal of pharmacology 588 (2-3), 217-231, 2008 | 67 | 2008 |