Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer TR Cox, JT Erler Disease models & mechanisms 4 (2), 165-178, 2011 | 1782 | 2011 |
Pre-metastatic niches: organ-specific homes for metastases H Peinado, H Zhang, IR Matei, B Costa-Silva, A Hoshino, G Rodrigues, ... Nature Reviews Cancer 17 (5), 302-317, 2017 | 1652 | 2017 |
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche JT Erler, KL Bennewith, TR Cox, G Lang, D Bird, A Koong, QT Le, ... Cancer cell 15 (1), 35-44, 2009 | 1380 | 2009 |
The rationale for targeting the LOX family in cancer HE Barker, TR Cox, JT Erler Nature Reviews Cancer 12 (8), 540-552, 2012 | 613 | 2012 |
LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis TR Cox, D Bird, AM Baker, HE Barker, MWY Ho, G Lang, JT Erler Cancer research 73 (6), 1721-1732, 2013 | 592 | 2013 |
The matrix in cancer TR Cox Nature Reviews Cancer 21 (4), 217-238, 2021 | 565 | 2021 |
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase TR Cox, RMH Rumney, EM Schoof, L Perryman, AM Høye, A Agrawal, ... Nature 522 (7554), 106-110, 2015 | 561 | 2015 |
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer AS Cazet, MN Hui, BL Elsworth, SZ Wu, D Roden, CL Chan, JN Skhinas, ... Nature communications 9 (1), 2897, 2018 | 371 | 2018 |
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK AM Baker, D Bird, G Lang, TR Cox, JT Erler Oncogene 32 (14), 1863-1868, 2013 | 344 | 2013 |
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution HE Barker, J Chang, TR Cox, G Lang, D Bird, M Nicolau, HR Evans, ... Cancer research 71 (5), 1561-1572, 2011 | 321 | 2011 |
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer SZ Wu, DL Roden, C Wang, H Holliday, K Harvey, AS Cazet, KJ Murphy, ... The EMBO journal 39 (19), e104063, 2020 | 275 | 2020 |
CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer BA Pereira, C Vennin, M Papanicolaou, CR Chambers, D Herrmann, ... Trends in cancer 5 (11), 724-741, 2019 | 260 | 2019 |
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis C Vennin, VT Chin, SC Warren, MC Lucas, D Herrmann, A Magenau, ... Science Translational Medicine 9, 2017 | 252 | 2017 |
Lamin A/C is a risk biomarker in colorectal cancer ND Willis, TR Cox, SF Rahman-Casans, K Smits, SA Przyborski, ... PloS one 3 (8), e2988, 2008 | 248 | 2008 |
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis C Vennin, VT Chin, SC Warren, MC Lucas, D Herrmann, A Magenau, ... Science translational medicine 9 (384), eaai8504, 2017 | 246 | 2017 |
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer AM Baker, TR Cox, D Bird, G Lang, GI Murray, XF Sun, SM Southall, ... Journal of the National Cancer Institute 103 (5), 407-424, 2011 | 232 | 2011 |
Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential L Wullkopf, AKV West, N Leijnse, TR Cox, CD Madsen, LB Oddershede, ... Molecular biology of the cell 29 (20), 2378-2385, 2018 | 224 | 2018 |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan C Vennin, P Mélénec, R Rouet, M Nobis, AS Cazet, KJ Murphy, ... Nature communications 10 (1), 3637, 2019 | 208 | 2019 |
Reshaping the tumor stroma for treatment of pancreatic cancer C Vennin, KJ Murphy, JP Morton, TR Cox, M Pajic, P Timpson Gastroenterology 154 (4), 820-838, 2018 | 200 | 2018 |
The extracellular matrix as a key regulator of intracellular signalling networks JF Hastings, JN Skhinas, D Fey, DR Croucher, TR Cox British journal of pharmacology 176 (1), 82-92, 2019 | 182 | 2019 |