Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance JQ Wang, Y Yang, CY Cai, QX Teng, Q Cui, J Lin, YG Assaraf, ZS Chen Drug Resistance Updates 54, 100743, 2021 | 144 | 2021 |
Signaling pathways and therapeutic interventions in gastric cancer ZN Lei, QX Teng, Q Tian, W Chen, Y Xie, K Wu, Q Zeng, L Zeng, Y Pan, ... Signal transduction and targeted therapy 7 (1), 358, 2022 | 96 | 2022 |
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates JQ Wang, ZX Wu, Y Yang, QX Teng, YD Li, ZN Lei, KA Jani, N Kaushal, ... Journal of Evidence‐Based Medicine 14 (3), 232-256, 2021 | 84 | 2021 |
Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells ZX Wu, QX Teng, CY Cai, JQ Wang, ZN Lei, Y Yang, YF Fan, JY Zhang, ... Biochemical pharmacology 166, 120-127, 2019 | 59 | 2019 |
Olmutinib (BI1482694/HM61713), a novel epidermal growth factor receptor tyrosine kinase inhibitor, reverses ABCG2-mediated multidrug resistance in cancer cells W Zhang, YF Fan, CY Cai, JQ Wang, QX Teng, ZN Lei, L Zeng, P Gupta, ... Frontiers in pharmacology 9, 1097, 2018 | 56 | 2018 |
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo AA De Vera, P Gupta, Z Lei, D Liao, S Narayanan, Q Teng, SE Reznik, ... Cancer letters 442, 91-103, 2019 | 54 | 2019 |
VS-4718 antagonizes multidrug resistance in ABCB1-and ABCG2-overexpressing cancer cells by inhibiting the efflux function of ABC transporters N Ji, Y Yang, CY Cai, ZN Lei, JQ Wang, P Gupta, QX Teng, ZS Chen, ... Frontiers in Pharmacology 9, 1236, 2018 | 53 | 2018 |
Venetoclax, a BCL-2 inhibitor, enhances the efficacy of chemotherapeutic agents in wild-type ABCG2-overexpression-mediated MDR cancer cells JQ Wang, JY Li, QX Teng, ZN Lei, N Ji, Q Cui, L Zeng, Y Pan, DH Yang, ... Cancers 12 (2), 466, 2020 | 44 | 2020 |
Tivantinib, A c-met inhibitor in clinical trials, is susceptible to ABCG2-mediated drug resistance ZX Wu, Y Yang, QX Teng, JQ Wang, ZN Lei, JQ Wang, S Lusvarghi, ... Cancers 12 (1), 186, 2020 | 42 | 2020 |
Erdafitinib antagonizes ABCB1-mediated multidrug resistance in cancer cells W Feng, M Zhang, ZX Wu, JQ Wang, XD Dong, Y Yang, QX Teng, ... Frontiers in oncology 10, 955, 2020 | 38 | 2020 |
Overexpression of ABCB1 transporter confers resistance to mTOR inhibitor WYE-354 in cancer cells J Wang, DH Yang, Y Yang, JQ Wang, CY Cai, ZN Lei, QX Teng, ZX Wu, ... International journal of molecular sciences 21 (4), 1387, 2020 | 38 | 2020 |
Understanding and targeting resistance mechanisms in cancer ZN Lei, Q Tian, QX Teng, JND Wurpel, L Zeng, Y Pan, ZS Chen MedComm 4 (3), e265, 2023 | 35 | 2023 |
Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro Y Yang, N Ji, QX Teng, CY Cai, JQ Wang, ZX Wu, ZN Lei, S Lusvarghi, ... Frontiers in oncology 10, 700, 2020 | 34 | 2020 |
Dual TTK/CLK2 inhibitor, CC‐671, selectively antagonizes ABCG2‐mediated multidrug resistance in lung cancer cells ZX Wu, Y Yang, G Wang, JQ Wang, QX Teng, L Sun, ZN Lei, L Lin, ... Cancer Science 111 (8), 2872-2882, 2020 | 32 | 2020 |
Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators S Wang, SQ Wang, QX Teng, L Yang, ZN Lei, XH Yuan, JF Huo, XB Chen, ... Journal of Medicinal Chemistry 63 (24), 15979-15996, 2020 | 30 | 2020 |
Antimicrobial peptide reverses ABCB1-mediated chemotherapeutic drug resistance X Luo, QX Teng, JY Dong, DH Yang, M Wang, W Dessie, JJ Qin, ZN Lei, ... Frontiers in Pharmacology 11, 1208, 2020 | 30 | 2020 |
Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor Y Yang, N Ji, CY Cai, JQ Wang, ZN Lei, QX Teng, ZX Wu, Q Cui, Y Pan, ... Cancer Communications 40 (7), 285-300, 2020 | 27 | 2020 |
M3814, a DNA-PK inhibitor, modulates ABCG2-mediated multidrug resistance in lung cancer cells ZX Wu, Z Peng, Y Yang, JQ Wang, QX Teng, ZN Lei, YG Fu, K Patel, L Liu, ... Frontiers in Oncology 10, 674, 2020 | 26 | 2020 |
Revisiting mTOR inhibitors as anticancer agents QX Teng, YV Ashar, P Gupta, E Gadee, YF Fan, SE Reznik, JND Wurpel, ... Drug Discovery Today 24 (10), 2086-2095, 2019 | 26 | 2019 |
Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells ZN Lei, QX Teng, ZX Wu, FF Ping, P Song, JND Wurpel, ZS Chen MedComm 2 (4), 765-777, 2021 | 25 | 2021 |