Design and evolution of an enzyme with a non-canonical organocatalytic mechanism AJ Burke, SL Lovelock, A Frese, R Crawshaw, M Ortmayer, M Dunstan, ... Nature 570 (7760), 219-223, 2019 | 151 | 2019 |
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction R Crawshaw, AE Crossley, L Johannissen, AJ Burke, S Hay, C Levy, ... Nature chemistry 14 (3), 313-320, 2022 | 64 | 2022 |
Enzymes with noncanonical amino acids J Zhao, AJ Burke, AP Green Current Opinion in Chemical Biology 55, 136-144, 2020 | 53 | 2020 |
An engineered cytidine deaminase for biocatalytic production of a key intermediate of the Covid-19 antiviral molnupiravir AJ Burke, WR Birmingham, Y Zhuo, TW Thorpe, B Zucoloto da Costa, ... Journal of the American Chemical Society 144 (9), 3761-3765, 2022 | 41 | 2022 |
Biocatalysis: landmark discoveries and applications in chemical synthesis A O’Connell, A Barry, AJ Burke, AE Hutton, EL Bell, AP Green, E O’Reilly Chemical Society Reviews, 2024 | 21 | 2024 |
Multicomponent synthesis of the SARS-CoV-2 main protease inhibitor nirmatrelvir HD Preschel, RT Otte, Y Zhuo, RE Ruscoe, AJ Burke, R Kellerhals, ... The Journal of organic chemistry 88 (17), 12565-12571, 2023 | 11 | 2023 |
Strategies for designing biocatalysts with new functions EL Bell, AE Hutton, AJ Burke, A O’Connell, A Barry, E O’Reilly, AP Green Chemical Society Reviews, 2024 | 9 | 2024 |
Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines AJ Burke, TM Lister, JR Marshall, MJB Brown, R Lloyd, AP Green, ... ChemCatChem 15 (11), e202300256, 2023 | 5 | 2023 |
A biocatalytic approach to a key intermediate for the synthesis of the COVID-19 experimental drug Molnupiravir A Burke, W Birmingham, Y Zhuo, C BZd, R Crawshaw, T Thorpe, I Rowles, ... | 5 | 2021 |
Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues CJ Taylor, FJ Hardy, AJ Burke, RM Bednar, RA Mehl, AP Green, ... Protein Science 32 (5), e4640, 2023 | 4 | 2023 |
Chemoenzymatic multicomponent synthesis of nirmatrelvir HD Preschel, RT Otte, Y Zhuo, RE Ruscoe, AJ Burke, R Cowan, B Horst, ... | 3 | 2022 |
Engineering a Cytidine Aminotransferase for Biocatalytic Production of the Antiviral Molnupiravir A Burke, W Birmingham, Y Zhuo, BZ da Costa, R Crawshaw, T Thorpe, ... | 1 | 2021 |
Engineered Biocatalyst Permits Enantioselective Morita–Baylis–Hillman Reaction R CRAWSHAW, AE CROSSLEY, L JOHANNISSEN, AJ BURKE, S HAY, ... Science 374, 1612-1616, 2021 | | 2021 |
Engineering enzymes with non-canonical active site functionality SL Lovelock, AJ Burke, R Crawshaw, M Ortmayer, M Dunstan, C Levy, ... | | 2019 |