Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA D Kaida, H Motoyoshi, E Tashiro, T Nojima, M Hagiwara, K Ishigami, ... Nature chemical biology 3 (9), 576-583, 2007 | 736 | 2007 |
Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing T Nojima, T Gomes, ARF Grosso, H Kimura, MJ Dye, S Dhir, ... Cell 161 (3), 526-540, 2015 | 556 | 2015 |
Mitochondrial double-stranded RNA triggers antiviral signalling in humans A Dhir, S Dhir, LS Borowski, L Jimenez, M Teitell, A Rötig, YJ Crow, ... Nature 560 (7717), 238-242, 2018 | 475 | 2018 |
Distinctive patterns of transcription and RNA processing for human lincRNAs M Schlackow, T Nojima, T Gomes, A Dhir, M Carmo-Fonseca, ... Molecular cell 65 (1), 25-38, 2017 | 270 | 2017 |
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics T Nojima, NJ Proudfoot Nature reviews Molecular cell biology 23 (6), 389-406, 2022 | 219 | 2022 |
Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-loop formation, replication stress, and cellular senescence T Nojima, M Tellier, J Foxwell, CR de Almeida, SM Tan-Wong, S Dhir, ... Molecular cell 72 (6), 970-984. e7, 2018 | 167 | 2018 |
RNA polymerase II phosphorylated on CTD serine 5 interacts with the spliceosome during co-transcriptional splicing T Nojima, K Rebelo, T Gomes, AR Grosso, NJ Proudfoot, ... Molecular cell 72 (2), 369-379. e4, 2018 | 158 | 2018 |
The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export T Nojima, T Hirose, H Kimura, M Hagiwara Journal of Biological Chemistry 282 (21), 15645-15651, 2007 | 157 | 2007 |
Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia M Yoshida, N Kataoka, K Miyauchi, K Ohe, K Iida, S Yoshida, T Nojima, ... Proceedings of the National Academy of Sciences 112 (9), 2764-2769, 2015 | 123 | 2015 |
Selective roles of vertebrate PCF11 in premature and full-length transcript termination K Kamieniarz-Gdula, MR Gdula, K Panser, T Nojima, J Monks, ... Molecular cell 74 (1), 158-172. e9, 2019 | 115 | 2019 |
SCAF4 and SCAF8, mRNA anti-terminator proteins LH Gregersen, R Mitter, AP Ugalde, T Nojima, NJ Proudfoot, R Agami, ... Cell 177 (7), 1797-1813. e18, 2019 | 105 | 2019 |
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide T Nojima, T Gomes, M Carmo-Fonseca, NJ Proudfoot Nature protocols 11 (3), 413-428, 2016 | 105 | 2016 |
Influenza virus mounts a two-pronged attack on host RNA polymerase II transcription DLV Bauer, M Tellier, M Martínez-Alonso, T Nojima, NJ Proudfoot, ... Cell reports 23 (7), 2119-2129. e3, 2018 | 91 | 2018 |
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation M Tellier, J Zaborowska, L Caizzi, E Mohammad, T Velychko, B Schwalb, ... Nucleic acids research 48 (14), 7712-7727, 2020 | 74 | 2020 |
Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing T Nojima, T Oshiro-Ideue, H Nakanoya, H Kawamura, T Morimoto, ... Nucleic acids research 37 (19), 6515-6527, 2009 | 68 | 2009 |
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts R Sousa-Luis, G Dujardin, I Zukher, H Kimura, C Weldon, ... Molecular cell 81 (9), 1935-1950. e6, 2021 | 60 | 2021 |
Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection A Takeuchi, M Hosokawa, T Nojima, M Hagiwara PLoS One 5 (6), e10946, 2010 | 41 | 2010 |
Enhancers predominantly regulate gene expression during differentiation via transcription initiation MSC Larke, R Schwessinger, T Nojima, J Telenius, RA Beagrie, ... Molecular cell 81 (5), 983-997. e7, 2021 | 40 | 2021 |
Definition of RNA polymerase II CoTC terminator elements in the human genome T Nojima, M Dienstbier, S Murphy, NJ Proudfoot, MJ Dye Cell reports 3 (4), 1080-1092, 2013 | 39 | 2013 |
Cross-talks between transcription and post-transcriptional events within a ‘mRNA factory’ M Hagiwara, T Nojima Journal of biochemistry 142 (1), 11-15, 2007 | 29 | 2007 |