Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase DO Ozgun, C Yamali, HI Gul, P Taslimi, I Gulcin, T Yanik, CT Supuran Journal of enzyme inhibition and medicinal chemistry 31 (6), 1498-1501, 2016 | 144 | 2016 |
Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity DO Ozgun, HI Gul, C Yamali, H Sakagami, I Gulcin, M Sukuroglu, ... Bioorganic chemistry 84, 511-517, 2019 | 126 | 2019 |
Synthesis, molecular modeling, and biological evaluation of 4‐[5‐aryl‐3‐(thiophen‐2‐yl)‐4,5‐dihydro‐1H‐pyrazol‐1‐yl] benzenesulfonamides toward … C Yamali, HI Gul, A Ece, P Taslimi, I Gulcin Chemical biology & drug design 91 (4), 854-866, 2018 | 123 | 2018 |
New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors HI Gul, C Yamali, H Sakagami, A Angeli, J Leitans, A Kazaks, K Tars, ... Bioorganic Chemistry 77, 411-419, 2018 | 111 | 2018 |
Synthesis of 4-(2-substituted hydrazinyl) benzenesulfonamides and their carbonic anhydrase inhibitory effects HI Gul, K Kucukoglu, C Yamali, S Bilginer, H Yuca, I Ozturk, P Taslimi, ... Journal of enzyme inhibition and medicinal chemistry 31 (4), 568-573, 2016 | 74 | 2016 |
Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of … C Yamali, HI Gul, C Kazaz, S Levent, I Gulcin Bioorganic Chemistry 96, 103627, 2020 | 64 | 2020 |
Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines K Kucukoglu, F Oral, T Aydin, C Yamali, O Algul, H Sakagami, I Gulcin, ... Journal of enzyme inhibition and medicinal chemistry 31 (sup4), 20-24, 2016 | 60 | 2016 |
Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2, 3-dihydroinden-1-one and evaluation of their cytotoxicities M Tugrak, C Yamali, H Sakagami, HI Gul Journal of Enzyme Inhibition and Medicinal Chemistry 31 (5), 818-823, 2016 | 59 | 2016 |
Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases C Yamali, HI Gul, H Sakagami, CT Supuran Journal of enzyme inhibition and medicinal chemistry 31 (sup4), 125-131, 2016 | 58 | 2016 |
The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes C Yamali, M Tugrak, HI Gul, M Tanc, CT Supuran Journal of enzyme inhibition and medicinal chemistry 31 (6), 1678-1681, 2016 | 47 | 2016 |
Microwave-assisted synthesis and bioevaluation of new sulfonamides HI Gul, C Yamali, F Yesilyurt, H Sakagami, K Kucukoglu, I Gulcin, M Gul, ... Journal of enzyme inhibition and medicinal chemistry 32 (1), 369-374, 2017 | 46 | 2017 |
Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4, 5-dihydro-pyrazol-1-yl] benzenesulfonamides HI Gul, E Mete, SE Eren, H Sakagami, C Yamali, CT Supuran Journal of enzyme inhibition and medicinal chemistry 32 (1), 169-175, 2017 | 46 | 2017 |
Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII … HI Gul, C Yamali, M Bulbuller, PB Kirmizibayrak, M Gul, A Angeli, S Bua, ... Bioorganic chemistry 78, 290-297, 2018 | 45 | 2018 |
Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol H Inci Gul, C Yamali, A Tugce Yasa, E Unluer, H Sakagami, M Tanc, ... Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6), 1375-1380, 2016 | 44 | 2016 |
Synthesis, biological evaluation and in silico modelling studies of 1, 3, 5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective … C Yamali, HI Gul, A Ece, S Bua, A Angeli, H Sakagami, E Sahin, ... Bioorganic chemistry 92, 103222, 2019 | 38 | 2019 |
Aminoalkylated phenolic chalcones: investigation of biological effects on acetylcholinesterase and carbonic anhydrase I and II as potential lead enzyme inhibitors C Yamali, HI Gul, T Cakir, Y Demir, I Gulcin Letters in drug design & discovery 17 (10), 1283-1292, 2020 | 36 | 2020 |
Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5 … C Yamali, H Sakagami, Y Uesawa, K Kurosaki, K Satoh, Y Masuda, ... European journal of medicinal chemistry 217, 113351, 2021 | 34 | 2021 |
Curcumin analogue 1, 5-bis (4-hydroxy-3-((4-methylpiperazin-1-yl) methyl) phenyl) penta-1, 4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and … G Badr, HI Gul, C Yamali, AAM Mohamed, BM Badr, M Gul, AA Markeb, ... Bioorganic Chemistry 78, 46-57, 2018 | 34 | 2018 |
Synthesis of some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives incorporating aminothiazole moiety and investigation of their antioxidant … C Yamalı, H Ozan Gülcan, B Kahya, S Çobanoğlu, M Kadir Şüküroğlu, ... Medicinal Chemistry Research 24, 1210-1217, 2015 | 27 | 2015 |
Synthesis and cytotoxic activities of difluoro-dimethoxy chalcones C Yamali, H Inci Gul, D Ozmen Ozgun, H Sakagam, N Umemura, C Kazaz, ... Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2017 | 25 | 2017 |