Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs M Balasubramaniam, N Mainali, SK Bowroju, P Atluri, NR Penthala, ... Scientific reports 10 (1), 18326, 2020 | 28 | 2020 |
Design and synthesis of novel hybrid 8-hydroxy quinoline-indole derivatives as inhibitors of Aβ self-aggregation and metal chelation-induced Aβ aggregation SK Bowroju, N Mainali, S Ayyadevara, NR Penthala, S Krishnamachari, ... Molecules 25 (16), 3610, 2020 | 15 | 2020 |
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain N Mainali, X Li, X Wang, M Balasubramaniam, A Ganne, R Kore, ... Molecular and Cellular Biochemistry, 1-13, 2023 | 3 | 2023 |
Protein homeostasis in the aged and diseased heart N Mainali, S Ayyadevara, A Ganne, RJS Reis, JL Mehta The journal of cardiovascular aging 3 (2), 2023 | 3 | 2023 |
Leave-one-out-analysis (LOOA): web-based tool to predict influential proteins and interactions in aggregate-crosslinking proteomic data N Mainali, M Balasubramaniam, J Johnson, S Ayyadevara, RJS Reis Bioinformation 20 (1), 4, 2024 | 2 | 2024 |
Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan S Kakraba, S Ayyadevara, N Mainali, M Balasubramaniam, S Bowroju, ... Pharmaceuticals 16 (10), 1498, 2023 | 1 | 2023 |
Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity A Mazur, S Ayyadevara, N Mainali, S Patchett, M Uden, RI Roa, GM Fahy, ... Cryobiology 115, 104881, 2024 | | 2024 |
Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets M Balasubramaniam, A Ganne, N Mainali, S Pahal, S Ayyadevara, ... Iscience 27 (1), 2024 | | 2024 |
Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases Akshatha Ganne, Meenakshisundaram Balasubramaniam, Nirjal Mainali, Paavan ... International Journal of Molecular Sciences 23 (24), 20, 2022 | | 2022 |
Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G:: Hexokinase Interaction A Ganne, N Mainali, M Balasubramaniam, R Atluri, S Pahal, JJ Asante, ... | | |
Ezetimibe lowers risk of Alzheimer’s and Related Dementias over 7-fold, reducing aggregation in model systems by inhibiting 14-3-3G:: hexokinase interaction A Ganne, N Mainali, M Balasubramaniam, R Atluri, S Pahal, J Asante, ... | | |