Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo RE Jenkins, X Meng, VL Elliott, NR Kitteringham, M Pirmohamed, BK Park PROTEOMICS–Clinical Applications 3 (6), 720-729, 2009 | 153 | 2009 |
Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis P Whitaker, X Meng, SN Lavergne, S El-Ghaiesh, M Monshi, C Earnshaw, ... The Journal of Immunology 187 (1), 200-211, 2011 | 144 | 2011 |
Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac JR Kenny, JL Maggs, X Meng, D Sinnott, SE Clarke, BK Park, ... Journal of medicinal chemistry 47 (11), 2816-2825, 2004 | 118 | 2004 |
Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides AV Stachulski, X Meng Natural product reports 30 (6), 806-848, 2013 | 114 | 2013 |
Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis S El-Ghaiesh, MM Monshi, P Whitaker, R Jenkins, X Meng, J Farrell, ... Journal of Pharmacology and Experimental Therapeutics 341 (3), 597-610, 2012 | 113 | 2012 |
Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients X Meng, RE Jenkins, NG Berry, JL Maggs, J Farrell, CS Lane, ... Journal of Pharmacology and Experimental Therapeutics 338 (3), 841-849, 2011 | 110 | 2011 |
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients X Meng, Z Al-Attar, FS Yaseen, R Jenkins, C Earnshaw, P Whitaker, ... The Journal of Immunology 198 (11), 4217-4227, 2017 | 72 | 2017 |
The importance of hapten–protein complex formation in the development of drug allergy L Faulkner, X Meng, BK Park, DJ Naisbitt Current opinion in allergy and clinical immunology 14 (4), 293-300, 2014 | 70 | 2014 |
β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis RE Jenkins, FS Yaseen, MM Monshi, P Whitaker, X Meng, J Farrell, ... Chemical research in toxicology 26 (6), 963-975, 2013 | 70 | 2013 |
Amoxicillin and clavulanate form chemically and immunologically distinct multiple haptenic structures in patients X Meng, CJ Earnshaw, A Tailor, RE Jenkins, JC Waddington, P Whitaker, ... Chemical research in toxicology 29 (10), 1762-1772, 2016 | 66 | 2016 |
Mass spectrometric and functional aspects of drug–protein conjugation A Tailor, JC Waddington, X Meng, BK Park Chemical research in toxicology 29 (12), 1912-1935, 2016 | 64 | 2016 |
Investigation of the immunogenicity of diclofenac and diclofenac metabolites DJ Naisbitt, LS Sanderson, X Meng, AV Stachulski, SE Clarke, BK Park Toxicology letters 168 (1), 45-50, 2007 | 63 | 2007 |
Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients TG Hammond, X Meng, RE Jenkins, JL Maggs, AS Castelazo, SL Regan, ... Journal of Pharmacology and Experimental Therapeutics 350 (2), 387-402, 2014 | 60 | 2014 |
Promiscuous T-cell responses to drugs and drug-haptens FS Yaseen, K Saide, SH Kim, M Monshi, A Tailor, S Wood, X Meng, ... Journal of Allergy and Clinical Immunology 136 (2), 474-476. e8, 2015 | 58 | 2015 |
Detection of drug bioactivation in vivo: mechanism of nevirapine–albumin conjugate formation in patients X Meng, A Howarth, CJ Earnshaw, RE Jenkins, NS French, DJ Back, ... Chemical Research in Toxicology 26 (4), 575-583, 2013 | 53 | 2013 |
Auto-oxidation of isoniazid leads to isonicotinic-lysine adducts on human serum albumin X Meng, JL Maggs, T Usui, P Whitaker, NS French, DJ Naisbitt, BK Park Chemical research in toxicology 28 (1), 51-58, 2015 | 51 | 2015 |
Dapsone‐and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B* 13: 01 Q Zhao, K Alhilali, A Alzahrani, M Almutairi, J Amjad, H Liu, Y Sun, L Sun, ... Allergy 74 (8), 1533-1548, 2019 | 46 | 2019 |
Exosomal transport of hepatocyte‐derived drug‐modified proteins to the immune system MO Ogese, RE Jenkins, K Adair, A Tailor, X Meng, L Faulkner, ... Hepatology 70 (5), 1732-1749, 2019 | 44 | 2019 |
From the cover: characterization of isoniazid-specific T-cell clones in patients with anti-tuberculosis drug-related liver and skin injury T Usui, X Meng, K Saide, J Farrell, P Thomson, P Whitaker, J Watson, ... Toxicological sciences 155 (2), 420-431, 2017 | 42 | 2017 |
Kinetic and J-Resolved Statistical Total Correlation NMR Spectroscopy Approaches to Structural Information Recovery in Complex Reacting Mixtures: Application … CH Johnson, TJ Athersuch, ID Wilson, L Iddon, X Meng, AV Stachulski, ... Analytical chemistry 80 (13), 4886-4895, 2008 | 40 | 2008 |