| Inhibition of DYRK1A and GSK3B induces human β-cell proliferation W Shen, B Taylor, Q Jin, V Nguyen-Tran, S Meeusen, YQ Zhang, ... Nature communications 6 (1), 8372, 2015 | 228 | 2015 |
| A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation X Zhang, G Lu, M Sun, M Mahankali, Y Ma, M Zhang, W Hua, Y Hu, ... Nature chemistry 10 (5), 540-548, 2018 | 189 | 2018 |
| Probing Protein–Protein Interactions with a Genetically Encoded Photo‐crosslinking Amino Acid H Ai, W Shen, A Sagi, PR Chen, PG Schultz Chembiochem 12 (12), 1854, 2011 | 127 | 2011 |
| Small-molecule inducer of β cell proliferation identified by high-throughput screening W Shen, MS Tremblay, VA Deshmukh, W Wang, CM Filippi, G Harb, ... Journal of the American Chemical Society 135 (5), 1669-1672, 2013 | 113 | 2013 |
| Genetically encoded alkenes in yeast H Ai, W Shen, E Brustad, PG Schultz Angewandte Chemie 122 (5), 947-949, 2010 | 83 | 2010 |
| Genetic Incorporation of Unnatural Amino Acids into Proteins in Mycobacterium tuberculosis F Wang, S Robbins, J Guo, W Shen, PG Schultz PLoS One 5 (2), e9354, 2010 | 74 | 2010 |
| Selective DYRK1A inhibitor for the treatment of Type 1 Diabetes: Discovery of 6-azaindole derivative GNF2133 YA Liu, Q Jin, Y Zou, Q Ding, S Yan, Z Wang, X Hao, B Nguyen, X Zhang, ... Journal of medicinal chemistry 63 (6), 2958-2973, 2020 | 68 | 2020 |
| A chemically induced vaccine strategy for prostate cancer A Dubrovska, C Kim, J Elliott, W Shen, TH Kuo, DI Koo, C Li, T Tuntland, ... ACS chemical biology 6 (11), 1223-1231, 2011 | 64 | 2011 |
| Targeted disruption of Myc–Max oncoprotein complex by a small molecule SH Choi, M Mahankali, SJ Lee, M Hull, HM Petrassi, AK Chatterjee, ... ACS chemical biology 12 (11), 2715-2719, 2017 | 62 | 2017 |
| Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery PY Yang, H Zou, E Chao, L Sherwood, V Nunez, M Keeney, ... Proceedings of the National Academy of Sciences 113 (15), 4140-4145, 2016 | 59 | 2016 |
| Double-cuvette ISES: In situ estimation of enantioselectivity and relative rate for catalyst screening S Dey, KR Karukurichi, W Shen, DB Berkowitz Journal of the American Chemical Society 127 (24), 8610-8611, 2005 | 58 | 2005 |
| Neratinib protects pancreatic beta cells in diabetes A Ardestani, S Li, K Annamalai, B Lupse, S Geravandi, A Dobrowolski, ... Nature communications 10 (1), 5015, 2019 | 55 | 2019 |
| Stapled, long-acting glucagon-like peptide 2 analog with efficacy in dextran sodium sulfate induced mouse colitis models PY Yang, H Zou, C Lee, A Muppidi, E Chao, Q Fu, X Luo, D Wang, ... Journal of Medicinal Chemistry 61 (7), 3218-3223, 2018 | 51 | 2018 |
| “Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a … CD McCune, SJ Chan, ML Beio, W Shen, WJ Chung, LM Szczesniak, ... ACS Central Science 2 (4), 242-252, 2016 | 46 | 2016 |
| Design of potent and proteolytically stable oxyntomodulin analogs A Muppidi, H Zou, PY Yang, E Chao, L Sherwood, V Nunez, AK Woods, ... ACS chemical biology 11 (2), 324-328, 2016 | 44 | 2016 |
| Evolution of iron (II)‐finger peptides by using a bipyridyl amino acid M Kang, K Light, H Ai, W Shen, CH Kim, PR Chen, HS Lee, EI Solomon, ... ChemBioChem 15 (6), 822-825, 2014 | 42 | 2014 |
| The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1 P Sang, Z Zhou, Y Shi, C Lee, Z Amso, D Huang, T Odom, ... Science advances 6 (20), eaaz4988, 2020 | 38 | 2020 |
| Overcoming resistance to HER2 inhibitors through state-specific kinase binding CJ Novotny, S Pollari, JH Park, MA Lemmon, W Shen, KM Shokat Nature chemical biology 12 (11), 923-930, 2016 | 36 | 2016 |
| In situ enzymatic screening (ISES) of P, N-ligands for Ni (0)-mediated asymmetric intramolecular allylic amination DB Berkowitz, W Shen, G Maiti Tetrahedron: Asymmetry 15 (18), 2845-2851, 2004 | 35 | 2004 |
| YAP-dependent proliferation by a small molecule targeting annexin A2 SZ Shalhout, PY Yang, EM Grzelak, K Nutsch, S Shao, C Zambaldo, ... Nature Chemical Biology 17 (7), 767-775, 2021 | 32 | 2021 |
