The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ... Science 318 (5855), 1469-1472, 2007 | 1799 | 2007 |
The hormonal control of food intake AP Coll, IS Farooqi, S O'Rahilly Cell 129 (2), 251-262, 2007 | 787 | 2007 |
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36 BG Challis, AP Coll, GSH Yeo, SB Pinnock, SL Dickson, RR Thresher, ... Proceedings of the National Academy of Sciences 101 (13), 4695-4700, 2004 | 463 | 2004 |
GDF15 mediates the effects of metformin on body weight and energy balance AP Coll, M Chen, P Taskar, D Rimmington, S Patel, JA Tadross, I Cimino, ... Nature 578 (7795), 444-448, 2020 | 419 | 2020 |
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia EW Roberts, A Deonarine, JO Jones, AE Denton, C Feig, SK Lyons, ... Journal of Experimental Medicine 210 (6), 1137-1151, 2013 | 383 | 2013 |
GDF15 provides an endocrine signal of nutritional stress in mice and humans S Patel, A Alvarez-Guaita, A Melvin, D Rimmington, A Dattilo, ... Cell metabolism 29 (3), 707-718. e8, 2019 | 357 | 2019 |
Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity TR Flint, T Janowitz, CM Connell, EW Roberts, AE Denton, AP Coll, ... Cell metabolism 24 (5), 672-684, 2016 | 322 | 2016 |
Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse BG Challis, SB Pinnock, AP Coll, RN Carter, SL Dickson, S O’rahilly Biochemical and biophysical research communications 311 (4), 915-919, 2003 | 304 | 2003 |
Proopiomelanocortin and energy balance: insights from human and murine genetics AP Coll, IS Farooqi, BG Challis, GSH Yeo, S O’Rahilly The Journal of Clinical Endocrinology & Metabolism 89 (6), 2557-2562, 2004 | 292 | 2004 |
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats YCL Tung, E Ayuso, X Shan, F Bosch, S O'Rahilly, AP Coll, GSH Yeo PloS one 5 (1), e8771, 2010 | 224 | 2010 |
Trim28 haploinsufficiency triggers bi-stable epigenetic obesity K Dalgaard, K Landgraf, S Heyne, A Lempradl, J Longinotto, K Gossens, ... Cell 164 (3), 353-364, 2016 | 211 | 2016 |
Hypothalamic AMPK-ER stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance N Martínez-Sánchez, P Seoane-Collazo, C Contreras, L Varela, ... Cell metabolism 26 (1), 212-229. e12, 2017 | 203 | 2017 |
Role for the obesity-related FTO gene in the cellular sensing of amino acids P Gulati, MK Cheung, R Antrobus, CD Church, HP Harding, YCL Tung, ... Proceedings of the National Academy of Sciences 110 (7), 2557-2562, 2013 | 199 | 2013 |
Closed-loop insulin delivery for glycemic control in noncritical care L Bally, H Thabit, S Hartnell, E Andereggen, Y Ruan, ME Wilinska, ... New England Journal of Medicine 379 (6), 547-556, 2018 | 187 | 2018 |
Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse F McMurray, CD Church, R Larder, G Nicholson, S Wells, L Teboul, ... PLoS genetics 9 (1), e1003166, 2013 | 171 | 2013 |
POMC: the physiological power of hormone processing E Harno, T Gali Ramamoorthy, AP Coll, A White Physiological reviews 98 (4), 2381-2430, 2018 | 169 | 2018 |
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing BYH Lam, I Cimino, J Polex-Wolf, SN Kohnke, D Rimmington, V Iyemere, ... Molecular metabolism 6 (5), 383-392, 2017 | 147 | 2017 |
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone J Grosse, H Heffron, K Burling, M Akhter Hossain, AM Habib, GJ Rogers, ... Proceedings of the National Academy of Sciences 111 (30), 11133-11138, 2014 | 143 | 2014 |
Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus YCL Tung, M Ma, S Piper, A Coll, S O'Rahilly, GSH Yeo Journal of Neuroscience 28 (47), 12419-12426, 2008 | 125 | 2008 |
Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial H Thabit, S Hartnell, JM Allen, A Lake, ME Wilinska, Y Ruan, ML Evans, ... The lancet Diabetes & endocrinology 5 (2), 117-124, 2017 | 118 | 2017 |