Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer C Szabo, C Coletta, C Chao, K Módis, B Szczesny, A Papapetropoulos, ... Proceedings of the National Academy of Sciences 110 (30), 12474-12479, 2013 | 717 | 2013 |
Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. MR Hellmich, HC Pant, E Wada, JF Battey Proceedings of the National Academy of Sciences 89 (22), 10867-10871, 1992 | 356 | 1992 |
Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion G Wang, Y Anini, W Wei, X Qi, AM O’Carroll, T Mochizuki, HQ Wang, ... Endocrinology 145 (3), 1342-1348, 2004 | 267 | 2004 |
The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer MR Hellmich, C Coletta, C Chao, C Szabo Antioxidants & redox signaling 22 (5), 424-448, 2015 | 227 | 2015 |
Hydrogen sulfide and cancer MR Hellmich, C Szabo Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide, 233-241, 2015 | 224 | 2015 |
Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme. MR Hellmich, F Strumwasser Cell Regulation 2 (3), 193-202, 1991 | 191 | 1991 |
Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth MR Hellmich, XL Rui, HL Hellmich, RYD Fleming, BM Evers, ... Journal of Biological Chemistry 275 (41), 32122-32128, 2000 | 186 | 2000 |
Bombesin stimulates nuclear factor κB activation and expression of proangiogenic factors in prostate cancer cells L Levine, JA Lucci III, B Pazdrak, JZ Cheng, YS Guo, CM Townsend Jr, ... Cancer research 63 (13), 3495-3502, 2003 | 174 | 2003 |
Consensus molecular subtypes of colorectal cancer and their clinical implications K Thanki, ME Nicholls, A Gajjar, AJ Senagore, S Qiu, C Szabo, ... International biological and biomedical journal 3 (3), 105, 2017 | 157 | 2017 |
Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury RT Ethridge, DH Chung, M Slogoff, RA Ehlers, MR Hellmich, ... Gastroenterology 123 (4), 1311-1322, 2002 | 154 | 2002 |
Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells YS Guo, MR Hellmich, XD Wen, CM Townsend Journal of Biological Chemistry 276 (25), 22941-22947, 2001 | 152 | 2001 |
Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues RP Thomas, MR Hellmich, CM Townsend Jr, BM Evers Endocrine Reviews 24 (5), 571-599, 2003 | 150 | 2003 |
Glutamine deprivation induces apoptosis in intestinal epithelial cells HT Papaconstantinou, KO Hwang, S Rajaraman, MR Hellmich, ... Surgery 124 (2), 152-160, 1998 | 150 | 1998 |
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects K Módis, EM Bos, E Calzia, H Van Goor, C Coletta, A Papapetropoulos, ... British journal of pharmacology 171 (8), 2123-2146, 2014 | 147 | 2014 |
Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1 DA Litvak, BM Evers, KO Hwang, MR Hellmich, TC Ko, CM Townsend Jr Surgery 124 (2), 161-170, 1998 | 147 | 1998 |
Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells Q Wang, X Wang, A Hernandez, MR Hellmich, Z Gatalica, BM Evers Journal of Biological Chemistry 277 (39), 36602-36610, 2002 | 145 | 2002 |
Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin K Iwase, BM Evers, MR Hellmich, YS Guo, S Higashide, HJ Kim, ... Gastroenterology 113 (3), 782-790, 1997 | 126 | 1997 |
Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways: evidence for involvement of ERK5 kinase and transactivation … YS Guo, JZ Cheng, GF Jin, JS Gutkind, MR Hellmich, CM Townsend Journal of Biological Chemistry 277 (50), 48755-48763, 2002 | 120 | 2002 |
Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis CNM Phillips, JR Zatarain, ME Nicholls, C Porter, SG Widen, K Thanki, ... Cancer research 77 (21), 5741-5754, 2017 | 118 | 2017 |
Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation G Oláh, K Módis, G Törö, MR Hellmich, B Szczesny, C Szabo Biochemical pharmacology 149, 186-204, 2018 | 117 | 2018 |