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Manuel Winkler
Manuel Winkler
Medical Faculty Mannheim, Heidelberg University
在 medma.uni-heidelberg.de 的电子邮件经过验证
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Single-cell RNA sequencing of tumor-infiltrating NK cells reveals that inhibition of transcription factor HIF-1α unleashes NK cell activity
J Ni, X Wang, A Stojanovic, Q Zhang, M Wincher, L Bühler, A Arnold, ...
Immunity 52 (6), 1075-1087. e8, 2020
2452020
Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
M Winkler, T Staniczek, SW Kürschner, CD Schmid, H Schönhaber, ...
Journal of hepatology 74 (2), 380-393, 2021
1242021
Hepatic endothelial notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling
SA Wohlfeil, V Häfele, B Dietsch, K Schledzewski, M Winkler, J Zierow, ...
Cancer research 79 (3), 598-610, 2019
542019
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torre, C Sticht, ...
Nature Communications 12 (1), 6963, 2021
202021
Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1-and Stabilin-2-deficient liver sinusoidal endothelial cells
V Olsavszky, C Sticht, CD Schmid, M Winkler, SA Wohlfeil, A Olsavszky, ...
Gene 768, 145284, 2021
202021
Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior
M Winkler, S Biswas, SM Berger, M Küchler, L Preisendörfer, M Choo, ...
Molecular psychiatry 25 (11), 2979-2993, 2020
202020
Influence of gadolinium-based contrast agents on tissue sodium quantification in sodium magnetic resonance imaging
NK Paschke, W Neumann, T Uhrig, M Winkler, E Neumaier-Probst, ...
Investigative radiology 53 (9), 555-562, 2018
192018
ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver
CD Schmid, V Olsavszky, M Reinhart, V Weyer, FA Trogisch, C Sticht, ...
Hepatology 77 (4), 1211-1227, 2023
182023
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9
FA Trogisch, A Abouissa, M Keles, A Birke, M Fuhrmann, GM Dittrich, ...
Science translational medicine 16 (736), eabq4581, 2024
142024
Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment
SA Wohlfeil, V Häfele, B Dietsch, C Weller, C Sticht, AS Jauch, M Winkler, ...
Journal of translational medicine 20 (1), 62, 2022
122022
Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages
S Biswas, M Adrian, K Evdokimov, K Schledzewski, J Weber, M Winkler, ...
Biochemical and biophysical research communications 464 (4), 1078-1083, 2015
112015
Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing
K Evdokimov, S Biswas, K Schledzewski, M Winkler, C Gorzelanny, ...
Biochemical and Biophysical Research Communications 475 (4), 342-349, 2016
82016
Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization
K Evdokimov, S Biswas, M Adrian, J Weber, K Schledzewski, M Winkler, ...
Biochemical and Biophysical Research Communications 434 (1), 22-27, 2013
82013
Imbalanced activation of Wnt-/β-catenin-signaling in liver endothelium alters normal sinusoidal differentiation
PS Koch, K Sandorski, J Heil, CD Schmid, SW Kürschner, J Hoffmann, ...
Frontiers in Physiology 12, 722394, 2021
62021
Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase
S Biswas, M Adrian, J Weber, K Evdokimov, M Winkler, C Géraud
Biochemical and Biophysical Research Communications 477 (4), 661-666, 2016
52016
Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABAB receptor signaling.
M Winkler, S Biswas, SM Berger, M Küchler, L Preisendörfer, M Choo, ...
Molecular psychiatry 25 (11), 2645, 2020
12020
Protocol for isolating and purifying murine liver sinusoidal endothelial cells for in vitro culture and functional assays
S Papaioannou, JX See, T Baljkas, P Reiners-Koch, M Winkler, ...
STAR protocols 6 (1), 103554, 2025
2025
Spontaneous regression of primary cutaneous diffuse large B‐cell lymphoma, leg type: A case series and review of the literature
M Winkler, JD Albrecht, C Sauer, T Kordaß, E Guenova, E Livingstone, ...
The Journal of Dermatology 51 (9), 1233-1239, 2024
2024
A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells
A Babin-Ebell Gonçalves, Y Mao, T Baljkas, F Wiedmann, F Pilz, ...
bioRxiv, 2024.03. 11.584492, 2024
2024
LEDA-1/PIANP INFLUENCES TELENCEPHALIC NEUROGLIA AND CEREBELLAR HISTOARCHITECTURE
M Kuechler, M Winkler, C Géraud, OVBU Halbach
IBRO Neuroscience Reports 15, S594, 2023
2023
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