The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids N Mustafi, A Grünberger, D Kohlheyer, M Bott, J Frunzke Metabolic engineering 14 (4), 449-457, 2012 | 255 | 2012 |
Miniaturizing free‐flow electrophoresis–a critical review D Kohlheyer, JCT Eijkel, A van den Berg, RBM Schasfoort Electrophoresis 29 (5), 977-993, 2008 | 217 | 2008 |
Single-cell microfluidics: opportunity for bioprocess development A Grünberger, W Wiechert, D Kohlheyer Current opinion in biotechnology 29, 15-23, 2014 | 193 | 2014 |
Free-flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes D Kohlheyer, GAJ Besselink, S Schlautmann, RBM Schasfoort Lab on a Chip 6 (3), 374-380, 2006 | 182 | 2006 |
Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways G Schendzielorz, M Dippong, A Grunberger, D Kohlheyer, A Yoshida, ... ACS synthetic biology 3 (1), 21-29, 2014 | 167 | 2014 |
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level A Grünberger, N Paczia, C Probst, G Schendzielorz, L Eggeling, S Noack, ... Lab on a Chip 12 (11), 2060-2068, 2012 | 134 | 2012 |
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium S Unthan, A Grünberger, J van Ooyen, J Gätgens, J Heinrich, N Paczia, ... Biotechnology and bioengineering 111 (2), 359-371, 2014 | 131 | 2014 |
Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains N Mustafi, A Grünberger, R Mahr, S Helfrich, K Nöh, B Blombach, ... PloS one 9 (1), e85731, 2014 | 127 | 2014 |
Microfluidic high-resolution free-flow isoelectric focusing D Kohlheyer, JCT Eijkel, S Schlautmann, A Van Den Berg, ... Analytical chemistry 79 (21), 8190-8198, 2007 | 122 | 2007 |
Homogenizing bacterial cell factories: analysis and engineering of phenotypic heterogeneity D Binder, T Drepper, KE Jaeger, F Delvigne, W Wiechert, D Kohlheyer, ... Metabolic engineering 42, 145-156, 2017 | 113 | 2017 |
Spatiotemporal microbial single‐cell analysis using a high‐throughput microfluidics cultivation platform A Grünberger, C Probst, S Helfrich, A Nanda, B Stute, W Wiechert, ... Cytometry Part A 87 (12), 1101-1115, 2015 | 106 | 2015 |
Bubble-free operation of a microfluidic free-flow electrophoresis chip with integrated Pt electrodes D Kohlheyer, JCT Eijkel, S Schlautmann, A van den Berg, ... Analytical chemistry 80 (11), 4111-4118, 2008 | 101 | 2008 |
A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood A Floris, S Staal, S Lenk, E Staijen, D Kohlheyer, J Eijkel, A van den Berg Lab on a Chip 10 (14), 1799-1806, 2010 | 99 | 2010 |
A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments A Burmeister, F Hilgers, A Langner, C Westerwalbesloh, Y Kerkhoff, ... Lab on a Chip 19 (1), 98-110, 2019 | 98 | 2019 |
Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation A Gruenberger, C Probst, A Heyer, W Wiechert, J Frunzke, D Kohlheyer JoVE (Journal of Visualized Experiments), e50560, 2013 | 84 | 2013 |
Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level AM Nanda, A Heyer, C Krämer, A Grünberger, D Kohlheyer, J Frunzke Journal of bacteriology 196 (1), 180-188, 2014 | 83 | 2014 |
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments A Grünberger, J van Ooyen, N Paczia, P Rohe, G Schiendzielorz, ... Biotechnology and bioengineering 110 (1), 220-228, 2013 | 83 | 2013 |
Time-resolved, single-cell analysis of induced and programmed cell death via non-invasive propidium iodide and counterstain perfusion CEM Krämer, W Wiechert, D Kohlheyer Scientific reports 6 (1), 32104, 2016 | 67 | 2016 |
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes C Probst, A Grünberger, W Wiechert, D Kohlheyer Journal of microbiological methods 95 (3), 470-476, 2013 | 62 | 2013 |
Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG D Binder, A Grünberger, A Loeschcke, C Probst, C Bier, J Pietruszka, ... Integrative biology 6 (8), 755-765, 2014 | 61 | 2014 |