| Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy AS Paraskar, S Soni, KT Chin, P Chaudhuri, KW Muto, J Berkowitz, ... Proceedings of the National Academy of Sciences 107 (28), 12435-12440, 2010 | 151 | 2010 |
| Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo T Kiziltepe, JD Ashley, JF Stefanick, YM Qi, NJ Alves, MW Handlogten, ... Blood cancer journal 2 (4), e64-e64, 2012 | 93 | 2012 |
| Intracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process MW Handlogten, A Lee‐O'Brien, G Roy, SV Levitskaya, R Venkat, S Singh, ... Biotechnology and bioengineering 115 (1), 126-138, 2018 | 81 | 2018 |
| Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability WK Chung, B Russell, Y Yang, M Handlogten, S Hudak, M Cao, J Wang, ... Biotechnology and bioengineering 114 (6), 1264-1274, 2017 | 59 | 2017 |
| Small-molecule-based affinity chromatography method for antibody purification via nucleotide binding site targeting NJ Alves, SD Stimple, MW Handlogten, JD Ashley, T Kiziltepe, B Bilgicer Analytical chemistry 84 (18), 7721-7728, 2012 | 50 | 2012 |
| Design of a heterobivalent ligand to inhibit IgE clustering on mast cells MW Handlogten, T Kiziltepe, DT Moustakas, B Bilgiçer Chemistry & biology 18 (9), 1179-1188, 2011 | 48 | 2011 |
| Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation MW Handlogten, T Kiziltepe, AP Serezani, MH Kaplan, B Bilgicer Nature chemical biology 9 (12), 789-795, 2013 | 47 | 2013 |
| Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site NJ Alves, MM Champion, JF Stefanick, MW Handlogten, DT Moustakas, ... Biomaterials 34 (22), 5700-5710, 2013 | 45 | 2013 |
| Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing MW Handlogten, M Zhu, S Ahuja Biotechnology and Bioengineering 114 (7), 1469-1477, 2017 | 39 | 2017 |
| Functionalized liposome purification via liposome extruder purification (LEP) NJ Alves, W Cusick, JF Stefanick, JD Ashley, MW Handlogten, B Bilgicer Analyst 138 (17), 4746-4751, 2013 | 35 | 2013 |
| Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production MW Handlogten, M Zhu, S Ahuja Biochemical Engineering Journal 133, 12-20, 2018 | 31 | 2018 |
| Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction MW Handlogten, J Wang, S Ahuja Biotechnology and bioengineering 117 (5), 1329-1336, 2020 | 27 | 2020 |
| Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation MW Handlogten, T Kiziltepe, B Bilgicer Biochemical Journal 449 (1), 91-99, 2013 | 26 | 2013 |
| Synthetic allergen design reveals the significance of moderate affinity epitopes in mast cell degranulation MW Handlogten, T Kiziltepe, NJ Alves, B Bilgicer ACS chemical biology 7 (11), 1796-1801, 2012 | 24 | 2012 |
| Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells P Sinharoy, AH Aziz, NI Majewska, S Ahuja, MW Handlogten Scientific reports 10 (1), 16620, 2020 | 23 | 2020 |
| Nonchromatographic affinity precipitation method for the purification of bivalently active pharmaceutical antibodies from biological fluids MW Handlogten, JF Stefanick, NJ Alves, B Bilgicer Analytical chemistry 85 (10), 5271-5278, 2013 | 21 | 2013 |
| Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region MW Handlogten, L Peng, EA Christian, W Xu, S Lin, R Venkat, ... MAbs 12 (1), 1779974, 2020 | 20 | 2020 |
| Enhancement of antibody selectivity via bicyclic complex formation JF Stefanick, T Kiziltepe, MW Handlogten, NJ Alves, B Bilgicer The Journal of Physical Chemistry Letters 3 (5), 598-602, 2012 | 17 | 2012 |
| A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen–IgE interactions in vivo MW Handlogten, AP Serezani, AL Sinn, KE Pollok, MH Kaplan, B Bilgicer The Journal of Immunology 192 (5), 2035-2041, 2014 | 16 | 2014 |
| Two-allergen model reveals complex relationship between IgE crosslinking and degranulation MW Handlogten, PE Deak, B Bilgicer Chemistry & biology 21 (11), 1445-1451, 2014 | 14 | 2014 |
