| Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, ... Proceedings of the national academy of sciences 114 (13), E2748-E2757, 2017 | 155 | 2017 |
| Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist T Macleod, R Doble, D McGonagle, CW Wasson, A Alase, M Stacey, ... Scientific reports 6 (1), 24880, 2016 | 100 | 2016 |
| IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis C Bridgewood, GW Fearnley, A Berekmeri, P Laws, T Macleod, ... Frontiers in immunology 9, 200, 2018 | 85 | 2018 |
| T helper 2 IL-4/IL-13 dual blockade with dupilumab is linked to some emergent T helper 17‒type diseases, including seronegative arthritis and enthesitis/enthesopathy, but not … C Bridgewood, M Wittmann, T Macleod, A Watad, D Newton, K Bhan, ... Journal of Investigative Dermatology 142 (10), 2660-2667, 2022 | 65 | 2022 |
| The immunological impact of IL-1 family cytokines on the epidermal barrier T Macleod, A Berekmeri, C Bridgewood, M Stacey, D McGonagle, ... Frontiers in Immunology 12, 808012, 2021 | 43 | 2021 |
| The proinflammatory cytokine IL-36γ is a global discriminator of harmless microbes and invasive pathogens within epithelial tissues T Macleod, JS Ainscough, C Hesse, S Konzok, A Braun, AL Buhl, ... Cell Reports 33 (11), 2020 | 32 | 2020 |
| Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema A Berekméri, A Latzko, A Alase, T Macleod, JS Ainscough, P Laws, ... Journal of Allergy and Clinical Immunology 142 (3), 988-991. e4, 2018 | 31 | 2018 |
| Antimicrobial peptide LL-37 facilitates intracellular uptake of RNA aptamer Apt 21-2 without inducing an inflammatory or interferon response T Macleod, J Ward, AA Alase, C Bridgewood, M Wittmann, ... Frontiers in immunology 10, 857, 2019 | 20 | 2019 |
| Role of neutrophil interleukin-23 in spondyloarthropathy spectrum disorders T Macleod, C Bridgewood, D McGonagle The Lancet Rheumatology 5 (1), e47-e57, 2023 | 7 | 2023 |
| Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis D McGonagle, P David, T Macleod, A Watad Nature Reviews Rheumatology 19 (12), 818-827, 2023 | 6 | 2023 |
| Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in inflammatory arthritis: a narrative of the emergence of MAPK-Activated Protein kinase inhibitors (MK2i) P Ganguly, T Macleod, C Wong, M Harland, D McGonagle Pharmaceuticals 16 (9), 1286, 2023 | 4 | 2023 |
| Molecular and cellular regulation of psoriatic inflammation T Macleod, C Bridgewood, I Hyde, M Heague, P Helliwell, M Stacey, ... Clinical Science 136 (12), 935-952, 2022 | 3 | 2022 |
| AB0011 CYTOMETRIC ANALYSIS OF ACTIVATED ENTHESEAL TISSUE RESIDENT T-CELLS REVEALS IL-17F AS THE DOMINANT IL-17 ISOFORM EXPRESSED BY INNATE AND ADAPTIVE LYMPHOCYTES N Mcdermott, T Macleod, AS Rao, V Borse, P Loughenbury, R Dunsmuir, ... Annals of the Rheumatic Diseases 82 (Suppl 1), 1184-1185, 2023 | 1 | 2023 |
| POS0331 UPADACITINIB EFFECTIVELY LIMITS IL-23 DRIVEN INFLAMMATION AT THE ENTHESIS BY INHIBITING T CELL STAT1 PHOSPHORYLATION, IL-17A AND TNFα PRODUCTION S Giryes, C Bridgewood, C Wong, T Macleod, D Mcgonagle Annals of the Rheumatic Diseases 81 (Suppl 1), 418-418, 2022 | 1 | 2022 |
| OP0244 INVESTIGATION OF NORMAL ENTHESIS IL-17F CELL SUBSETS, PROTEIN EXPRESSION AND ITS IMPACT ON ENTHESEAL MESENCHYMAL STEM CELL FUNCTION N Mcdermott, M Harland, C Wong, A Altaie, T Macleod, C Bridgewood, ... Annals of the Rheumatic Diseases 83 (Suppl 1), 109-110, 2024 | | 2024 |
| Pronounced benefits of JAK inhibition with baricitinib in COVID-19 pneumonia in obese but not lean subjects P David, O Hen, N Ben-Shabbat, T Macleod, H Amital, A Watad, ... RMD open 10 (2), e004045, 2024 | | 2024 |
| Preferential endogenous regulation of skin inflammation by IL-37 seems to be specific for psoriasis. G Ojak, T Macleod, I Hyde, A Berekmeri, D Kramer, S Tenzer, M Stacey, ... EXPERIMENTAL DERMATOLOGY 33 (3), 2024 | | 2024 |
| Anti-IL-5 biologics and rheumatoid arthritis: a single-centre 500 patient year exposure analysis NJ Dean, IJ Clifton, R Salman, C Bridgewood, J Nam, T Macleod, ... RMD open 9 (4), e003583, 2023 | | 2023 |
| CD14+CD64+ Classical Monocytes Are the Main Producers of IL-23 at the Enthesis N McDermott, T Macleod, A Altaie, L Straszynski, R Dunsmuir, V Borse, ... ARTHRITIS & RHEUMATOLOGY 75, 89-91, 2023 | | 2023 |
| POS0048 LIPOPOLYSACCHARIDE ACTIVATED ENTHESEAL MYELOID CELL INHIBITION WITH UPADACITINIB PARADOXICALLY INCREASES MYELOID PRO-INFLAMMATORY CYTOKINES INCLUDING TNF AND IL-23 BY … S Giryes, T Macleod, C Wong, M Harland, N Mcdermott, C Bridgewood, ... Annals of the Rheumatic Diseases 82 (Suppl 1), 232-233, 2023 | | 2023 |
