Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide JP Lévesque, J Hendy, Y Takamatsu, PJ Simmons, LJ Bendall The Journal of clinical investigation 111 (2), 187-196, 2003 | 985 | 2003 |
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs IG Winkler, NA Sims, AR Pettit, V Barbier, B Nowlan, F Helwani, IJ Poulton, ... Blood, The Journal of the American Society of Hematology 116 (23), 4815-4828, 2010 | 947 | 2010 |
Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony … JP Lévesque, Y Takamatsu, SK Nilsson, DN Haylock, PJ Simmons Blood, The Journal of the American Society of Hematology 98 (5), 1289-1297, 2001 | 620 | 2001 |
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow CL Semerad, MJ Christopher, F Liu, B Short, PJ Simmons, I Winkler, ... Blood 106 (9), 3020-3027, 2005 | 615 | 2005 |
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance IG Winkler, V Barbier, B Nowlan, RN Jacobsen, CE Forristal, JT Patton, ... Nature medicine 18 (11), 1651-1657, 2012 | 489 | 2012 |
Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. JP Levesque, DI Leavesley, S Niutta, M Vadas, PJ Simmons The Journal of experimental medicine 181 (5), 1805-1815, 1995 | 363 | 1995 |
Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment JP Lévesque, J Hendy, Y Takamatsu, B Williams, IG Winkler, PJ Simmons Experimental hematology 30 (5), 440-449, 2002 | 353 | 2002 |
The endosteal ‘osteoblastic’niche and its role in hematopoietic stem cell homing and mobilization JP Levesque, FM Helwani, IG Winkler Leukemia 24 (12), 1979-1992, 2010 | 330 | 2010 |
Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides. J Hatzfeld, ML Li, EL Brown, H Sookdeo, JP Levesque, T O'Toole, ... The Journal of experimental medicine 174 (4), 925-929, 1991 | 323 | 1991 |
Characterization of hematopoietic progenitor mobilization in protease-deficient mice JP Levesque, F Liu, PJ Simmons, T Betsuyaku, RM Senior, C Pham, ... Blood 104 (1), 65-72, 2004 | 322 | 2004 |
How I treat patients who mobilize hematopoietic stem cells poorly LB To, JP Levesque, KE Herbert Blood, The Journal of the American Society of Hematology 118 (17), 4530-4540, 2011 | 297 | 2011 |
Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches IG Winkler, V Barbier, R Wadley, ACW Zannettino, S Williams, ... Blood, The Journal of the American Society of Hematology 116 (3), 375-385, 2010 | 285 | 2010 |
Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta G Brooke, H Tong, JP Levesque, K Atkinson Stem cells and development 17 (5), 929-940, 2008 | 284 | 2008 |
Release from quiescence of CD34+ CD38-human umbilical cord blood cells reveals their potentiality to engraft adults. AA Cardoso, ML Li, P Batard, A Hatzfeld, EL Brown, JP Levesque, ... Proceedings of the National Academy of Sciences 90 (18), 8707-8711, 1993 | 259 | 1993 |
Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells JP Lévesque, J Hendy, IG Winkler, Y Takamatsu, PJ Simmons Experimental hematology 31 (2), 109-117, 2003 | 230 | 2003 |
Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors JP Levesque, DN Haylock, PJ Simmons | 207 | 1996 |
Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor … Y Takamatsu, PJ Simmons, RJ Moore, HA Morris, LB To, JP Lévesque Blood, The Journal of the American Society of Hematology 92 (9), 3465-3473, 1998 | 185 | 1998 |
Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation IG Winkler, AR Pettit, LJ Raggatt, RN Jacobsen, CE Forristal, V Barbier, ... Leukemia 26 (7), 1594-1601, 2012 | 179 | 2012 |
Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1α and vascular endothelial growth factor A in bone marrow JP LEvesque, IG Winkler, J Hendy, B Williams, F Helwani, V Barbier, ... Stem cells 25 (8), 1954-1965, 2007 | 175 | 2007 |
Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone IG Winkler, JP Levesque Experimental hematology 34 (8), 996-1009, 2006 | 170 | 2006 |