Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome J Aguado, A Sola-Carvajal, V Cancila, G Revêchon, PF Ong, ... Nature communications 10 (1), 4990, 2019 | 105 | 2019 |
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs F Rossiello, J Aguado, S Sepe, F Iannelli, Q Nguyen, S Pitchiaya, ... Nature communications 8 (1), 13980, 2017 | 101 | 2017 |
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein EA Albornoz, AA Amarilla, N Modhiran, S Parker, XX Li, DK Wijesundara, ... Molecular psychiatry 28 (7), 2878-2893, 2023 | 83 | 2023 |
From “cellular” RNA to “smart” RNA: multiple roles of RNA in genome stability and beyond F Michelini, AP Jalihal, S Francia, C Meers, ZT Neeb, F Rossiello, U Gioia, ... Chemical reviews 118 (8), 4365-4403, 2018 | 83 | 2018 |
Telomere transcription in ageing J Aguado, FA di Fagagna, E Wolvetang Ageing research reviews 62, 101115, 2020 | 61 | 2020 |
Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids J Aguado, HK Chaggar, C Gómez‐Inclán, MR Shaker, HC Leeson, ... Aging Cell 20 (9), e13468, 2021 | 47 | 2021 |
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis A Slonchak, X Wang, J Aguado, JDJ Sng, H Chaggar, ME Freney, K Yan, ... Science advances 8 (48), eadd8095, 2022 | 25 | 2022 |
Klotho inhibits neuronal senescence in human brain organoids MR Shaker, J Aguado, HK Chaggar, EJ Wolvetang npj Aging and Mechanisms of Disease 7 (1), 18, 2021 | 21 | 2021 |
The hallmarks of aging in Ataxia-Telangiectasia J Aguado, C Gómez-Inclán, HC Leeson, MF Lavin, Y Shiloh, ... Ageing Research Reviews 79, 101653, 2022 | 17 | 2022 |
Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants A Isaacs, AA Amarilla, J Aguado, N Modhiran, EA Albornoz, AA Baradar, ... Frontiers in Immunology 13, 926262, 2022 | 13 | 2022 |
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology J Aguado, AA Amarilla, A Taherian Fard, EA Albornoz, A Tyshkovskiy, ... Nature aging 3 (12), 1561-1575, 2023 | 10 | 2023 |
Target-enrichment sequencing for detailed characterization of small RNAs Q Nguyen, J Aguado, F Iannelli, AM Suzuki, F Rossiello, ... Nature protocols 13 (4), 768-786, 2018 | 9 | 2018 |
Cellular senescence and premature aging in Down Syndrome L Peng, AA Baradar, J Aguado, E Wolvetang Mechanisms of Ageing and Development 212, 111824, 2023 | 8 | 2023 |
Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution A Taherian Fard, HC Leeson, J Aguado, G Pietrogrande, D Power, ... GeroScience 46 (1), 999-1015, 2024 | 4 | 2024 |
Noncoding RNA of Zika Virus Affects Interplay between Wnt-Signaling and Pro-Apoptotic Pathways in the Developing Brain Tissue A Slonchak, H Chaggar, J Aguado, E Wolvetang, AA Khromykh Viruses 15 (5), 1062, 2023 | 4 | 2023 |
Exploring aging interventions in human brain organoids J Aguado, EJ Wolvetang Aging (Albany NY) 14 (4), 1592, 2022 | 4 | 2022 |
Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress HC Leeson, J Aguado, C Gómez-Inclán, HK Chaggar, AT Fard, Z Hunter, ... Neurobiology of Disease, 106562, 2024 | | 2024 |
Insights into senolytic drugs for the treatment of SARS-CoV-2 infection in the brain J Aguado, AA Amarilla Nature Aging, 2023 | | 2023 |
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs I Rosso, C Jones-Weinert, F Rossiello, M Cabrini, S Brambillasca, ... Nature communications 14 (1), 7086, 2023 | | 2023 |
Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence G Pietrogrande, M Shaker, S Stednitz, F Soheilmoghaddam, J Aguado, ... bioRxiv, 2023.08. 29.555421, 2023 | | 2023 |