| Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness BH Stokes, SK Dhingra, K Rubiano, S Mok, J Straimer, NF Gnädig, I Deni, ... Elife 10, e66277, 2021 | 145 | 2021 |
| Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series MJ Palmer, X Deng, S Watts, G Krilov, A Gerasyuto, S Kokkonda, ... Journal of medicinal chemistry 64 (9), 6085-6136, 2021 | 39 | 2021 |
| Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance JL Small-Saunders, LM Hagenah, KJ Wicht, SK Dhingra, I Deni, J Kim, ... PLoS Pathogens 18 (2), e1010278, 2022 | 30 | 2022 |
| Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome SC Xie, RD Metcalfe, H Mizutani, T Puhalovich, E Hanssen, CJ Morton, ... Proceedings of the National Academy of Sciences 118 (39), e2107213118, 2021 | 27 | 2021 |
| Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending … BE Barber, M Fernandez, HB Patel, C Barcelo, SD Woolley, H Patel, ... The Lancet Infectious Diseases 22 (6), 879-890, 2022 | 25 | 2022 |
| Genomic and genetic approaches to studying antimalarial drug resistance and Plasmodium biology J Okombo, M Kanai, I Deni, DA Fidock Trends in parasitology 37 (6), 476-492, 2021 | 24 | 2021 |
| The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance JM Murithi, I Deni, CFA Pasaje, J Okombo, JL Bridgford, NF Gnädig, ... Cell chemical biology 29 (5), 824-839. e6, 2022 | 21 | 2022 |
| Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum A Lawong, S Gahalawat, J Okombo, J Striepen, T Yeo, S Mok, I Deni, ... Journal of medicinal chemistry 64 (5), 2739-2761, 2021 | 16 | 2021 |
| Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome I Deni, BH Stokes, KE Ward, KJ Fairhurst, CFA Pasaje, T Yeo, S Akbar, ... Cell chemical biology 30 (5), 470-485. e6, 2023 | 15 | 2023 |
| Identification of abundant and evolutionarily conserved opioid receptor circular RNAs in the nervous system modulated by morphine T Irie, R Shum, I Deni, A Hunkele, V Le Rouzic, J Xu, R Wilson, ... Molecular pharmacology 96 (2), 247-258, 2019 | 13 | 2019 |
| P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites BH Stokes, K Rubiano, SK Dhingra, S Mok, J Straimer, NF Gnädig, ... bioRxiv, 2021.01. 27.428390, 2021 | 4 | 2021 |
| Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3 PPS Calic, TD Ashton, M Mansouri, K Loi, KE Jarman, D Qiu, AM Lehane, ... European Journal of Medicinal Chemistry 276, 116677, 2024 | 3 | 2024 |
| A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo SC Xie, CW Tai, CJ Morton, L Ma, SC Huang, S Wittlin, Y Du, Y Hu, ... PLoS Pathogens 20 (12), e1012429, 2024 | | 2024 |
| INHIBITION MECHANISMS AND STRUCTURES OF PLASMODIUM-SELECTIVE PROTEASOME INHIBITORS DETERMINE IN VITRO RESISTANCE PROFILES I Deni, M Bogyo, W Zhan, H Zhang, YJ Liu, J Almaliti, LA Kirkman, ... AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 105 (5), 64-64, 2021 | | 2021 |
| Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine (vol 96, pg 247, 2019) T Irie, R Shum, I Deni, A Hunkele, V Le Rouzie, J Xu, R Wilson, ... MOLECULAR PHARMACOLOGY 96 (5), 526-526, 2019 | | 2019 |
| IDENTIFICATION OF ABUNDANT AND EVOLUTIONARILY CONSERVED OPIOID RECEPTOR CIRCULAR RNAS, AND THEIR MODULATION IN THE MOUSE NERVOUS SYSTEM BY CHRONIC MORPHINE T Irie, R Shum, I Deni, R Wilson, G Fischer, YX Pan, G Pasternak ANESTHESIA AND ANALGESIA 126 (4), 72-76, 2018 | | 2018 |
