Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll‐like receptor 4 RFP Schelbergen, AB Blom, MHJ van den Bosch, A Slöetjes, ... Arthritis & Rheumatism 64 (5), 1477-1487, 2012 | 210 | 2012 |
Osteoarthritis year in review 2020: biology MHJ van den Bosch Osteoarthritis and cartilage 29 (2), 143-150, 2021 | 166 | 2021 |
Inflammation in osteoarthritis: is it time to dampen the alarm (in) in this debilitating disease? MHJ Van den Bosch Clinical & Experimental Immunology 195 (2), 153-166, 2019 | 125 | 2019 |
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis RFP Schelbergen, W de Munter, MHJ Van den Bosch, F Lafeber, ... Annals of the rheumatic diseases 75 (1), 218-225, 2016 | 101 | 2016 |
Identifying effector molecules, cells, and cytokines of innate immunity in OA MHJ Van den Bosch, P Van Lent, PM Van der Kraan Osteoarthritis and Cartilage 28 (5), 532-543, 2020 | 94 | 2020 |
Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8 MH van den Bosch, AB Blom, PL van Lent, HM van Beuningen, ... Cellular signalling 26 (5), 951-958, 2014 | 85 | 2014 |
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis RF Schelbergen, EJ Geven, MHJ Van Den Bosch, H Eriksson, ... Annals of the rheumatic diseases 74 (12), 2254-2258, 2015 | 83 | 2015 |
Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis SCM Van Dalen, AB Blom, AW Slöetjes, MMA Helsen, J Roth, T Vogl, ... Osteoarthritis and cartilage 25 (3), 385-396, 2017 | 76 | 2017 |
Alarmin S100A9 induces proinflammatory and catabolic effects predominantly in the M1 macrophages of human osteoarthritic synovium MH van den Bosch, AB Blom, RF Schelbergen, MI Koenders, ... The Journal of rheumatology 43 (10), 1874-1884, 2016 | 76 | 2016 |
Induction of canonical Wnt signaling by synovial overexpression of selected Wnts leads to protease activity and early osteoarthritis-like cartilage damage MH van den Bosch, AB Blom, AW Sloetjes, MI Koenders, FA van de Loo, ... The American journal of pathology 185 (7), 1970-1980, 2015 | 68 | 2015 |
High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis W de Munter, MH Van Den Bosch, AW Slöetjes, KJ Croce, T Vogl, J Roth, ... Osteoarthritis and cartilage 24 (5), 844-855, 2016 | 66 | 2016 |
WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis MH Van den Bosch, AB Blom, V Kram, A Maeda, S Sikka, Y Gabet, ... Osteoarthritis and Cartilage 25 (11), 1900-1911, 2017 | 45 | 2017 |
Macrophage-derived extracellular vesicles as carriers of alarmins and their potential involvement in bone homeostasis BCH Pieters, A Cappariello, MHJ Van den Bosch, PLEM Van Lent, A Teti, ... Frontiers in immunology 10, 1901, 2019 | 44 | 2019 |
S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis NAJ Cremers, MHJ van den Bosch, S van Dalen, I Di Ceglie, G Ascone, ... Arthritis research & therapy 19, 1-15, 2017 | 42 | 2017 |
Induction of canonical Wnt signaling by the alarmins S100A8/A9 in murine knee joints: implications for osteoarthritis MH van den Bosch, AB Blom, RFP Schelbergen, T Vogl, JP Roth, ... Arthritis & rheumatology 68 (1), 152-163, 2016 | 37 | 2016 |
Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis MH van den Bosch, TA Gleissl, AB Blom, WB van den Berg, PL van Lent, ... Rheumatology 55 (9), 1536-1547, 2016 | 32 | 2016 |
S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis EJW Geven, MHJ van den Bosch, I Di Ceglie, G Ascone, ... Arthritis Research & Therapy 18, 1-12, 2016 | 28 | 2016 |
Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression BJ Evers, MHJ Van Den Bosch, AB Blom, PM van der Kraan, S Koëter, ... Frontiers in medicine 9, 973870, 2022 | 26 | 2022 |
Brief report: induction of matrix metalloproteinase expression by synovial Wnt signaling and association with disease progression in early symptomatic osteoarthritis MH van den Bosch, AB Blom, FA van de Loo, MI Koenders, FP Lafeber, ... Arthritis & Rheumatology 69 (10), 1978-1983, 2017 | 26 | 2017 |
Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo S Gran, L Honold, O Fehler, S Zenker, S Eligehausen, MT Kuhlmann, ... Theranostics 8 (9), 2407, 2018 | 25 | 2018 |