Myocardial substrate metabolism in the normal and failing heart WC Stanley, FA Recchia, GD Lopaschuk Physiological reviews 85 (3), 1093-1129, 2005 | 2541 | 2005 |
Myocardial fatty acid metabolism in health and disease GD Lopaschuk, JR Ussher, CDL Folmes, JS Jaswal, WC Stanley Physiological reviews 90 (1), 207-258, 2010 | 2367 | 2010 |
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ... Cell metabolism 7 (1), 45-56, 2008 | 2146 | 2008 |
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth S Bonnet, SL Archer, J Allalunis-Turner, A Haromy, C Beaulieu, ... Cancer cell 11 (1), 37-51, 2007 | 1945 | 2007 |
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A … PF Kantor, A Lucien, R Kozak, GD Lopaschuk Circulation research 86 (5), 580-588, 2000 | 1535 | 2000 |
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus BN Finck, JJ Lehman, TC Leone, MJ Welch, MJ Bennett, A Kovacs, X Han, ... The Journal of clinical investigation 109 (1), 121-130, 2002 | 1206 | 2002 |
Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions WC Stanley, GD Lopaschuk, JL Hall, JG McCormack Cardiovascular research 33 (2), 243-257, 1997 | 963 | 1997 |
Cardiovascular remodelling in coronary artery disease and heart failure G Heusch, P Libby, B Gersh, D Yellon, M Böhm, G Lopaschuk, L Opie The Lancet 383 (9932), 1933-1943, 2014 | 843 | 2014 |
Regulation of fatty acid oxidation in the mammalian heart in health and disease GD Lopaschuk, DD Belke, J Gamble, I Toshiyuki, BO Schönekess Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1213 (3 …, 1994 | 806 | 1994 |
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5’-AMP-activated protein … N Kudo, AJ Barr, RL Barr, S Desai, GD Lopaschuk Journal of Biological Chemistry 270 (29), 17513-17520, 1995 | 741 | 1995 |
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts MF Allard, BO Schonekess, SL Henning, DR English, GD Lopaschuk American Journal of Physiology-Heart and Circulatory Physiology 267 (2 …, 1994 | 725 | 1994 |
Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation GD Lopaschuk, JS Jaswal Journal of cardiovascular pharmacology 56 (2), 130-140, 2010 | 652 | 2010 |
Regulation of energy substrate metabolism in the diabetic heart WC Stanley, GD Lopaschuk, JG McCormack Cardiovascular research 34 (1), 25-33, 1997 | 650 | 1997 |
Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review GD Lopaschuk, S Verma Basic to Translational Science 5 (6), 632-644, 2020 | 597 | 2020 |
Cardiac energy metabolism in heart failure GD Lopaschuk, QG Karwi, R Tian, AR Wende, ED Abel Circulation research 128 (10), 1487-1513, 2021 | 594 | 2021 |
Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts M Saddik, GD Lopaschuk Journal of Biological Chemistry 266 (13), 8162-8170, 1991 | 507 | 1991 |
AMPK alterations in cardiac physiology and pathology: enemy or ally? JRB Dyck, GD Lopaschuk The Journal of physiology 574 (1), 95-112, 2006 | 486 | 2006 |
Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry T Fukao, GD Lopaschuk, GA Mitchell Prostaglandins, leukotrienes and essential fatty acids 70 (3), 243-251, 2004 | 485 | 2004 |
Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy N Fillmore, J Mori, GD Lopaschuk British journal of pharmacology 171 (8), 2080-2090, 2014 | 478 | 2014 |
Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart JS Jaswal, W Keung, W Wang, JR Ussher, GD Lopaschuk Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (7), 1333-1350, 2011 | 474 | 2011 |