| CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis JD Gillmore, E Gane, J Taubel, J Kao, M Fontana, ML Maitland, J Seitzer, ... New England Journal of Medicine 385 (6), 493-502, 2021 | 1092 | 2021 |
| A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and-independent growth of human tumor cell lines L Sepp-Lorenzino, Z Ma, E Rands, NE Kohl, JB Gibbs, A Oliff, N Rosen Cancer Research 55 (22), 5302-5309, 1995 | 547 | 1995 |
| Total synthesis of spirotryprostatin A, leading to the discovery of some biologically promising analogues S Edmondson, SJ Danishefsky, L Sepp-Lorenzino, N Rosen Journal of the American Chemical Society 121 (10), 2147-2155, 1999 | 531 | 1999 |
| Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90 C Schneider, L Sepp-Lorenzino, E Nimmesgern, O Ouerfelli, ... Proceedings of the National Academy of Sciences 93 (25), 14536-14541, 1996 | 520 | 1996 |
| Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells B Shi, L Sepp-Lorenzino, M Prisco, P Linsley, T DeAngelis, R Baserga Journal of Biological Chemistry 282 (45), 32582-32590, 2007 | 442 | 2007 |
| A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells G Chiosis, MN Timaul, B Lucas, PN Munster, FF Zheng, L Sepp-Lorenzino, ... Chemistry & biology 8 (3), 289-299, 2001 | 368 | 2001 |
| Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage W Tao, VJ South, Y Zhang, JP Davide, L Farrell, NE Kohl, ... Cancer cell 8 (1), 49-59, 2005 | 350 | 2005 |
| Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones MM Moasser, L Sepp-Lorenzino, NE Kohl, A Oliff, A Balog, DS Su, ... Proceedings of the National Academy of Sciences 95 (4), 1369-1374, 1998 | 277 | 1998 |
| Differential roles of PI3‐kinase and Kit tyrosine 821 in Kit receptor‐mediated proliferation, survival and cell adhesion in mast cells. H Serve, NS Yee, G Stella, L Sepp‐Lorenzino, JC Tan, P Besmer The EMBO journal 14 (3), 473-483, 1995 | 277 | 1995 |
| Herbimycin A induces the 20 S proteasome-and ubiquitin-dependent degradation of receptor tyrosine kinases L Sepp-Lorenzino, Z Ma, DE Lebwohl, A Vinitsky, N Rosen Journal of Biological Chemistry 270 (28), 16580-16587, 1995 | 241 | 1995 |
| Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment MT Abrams, ML Koser, J Seitzer, SC Williams, MA DiPietro, W Wang, ... Molecular therapy 18 (1), 171-180, 2010 | 209 | 2010 |
| Structure and function of the insulin-like growth factor I receptor L Sepp-Lorenzino Breast cancer research and treatment 47, 235-253, 1998 | 166 | 1998 |
| Synthesis and evaluation of geldanamycin-estradiol hybrids SD Kuduk, FF Zheng, L Sepp-Lorenzino, N Rosen, SJ Danishefsky Bioorganic & medicinal chemistry letters 9 (9), 1233-1238, 1999 | 150 | 1999 |
| Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. A Vinitsky, C Cardozo, L Sepp-Lorenzino, C Michaud, M Orlowski Journal of Biological Chemistry 269 (47), 29860-29866, 1994 | 145 | 1994 |
| A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells L Sepp-Lorenzino, N Rosen Journal of Biological Chemistry 273 (32), 20243-20251, 1998 | 134 | 1998 |
| 5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates R Parmar, JLS Willoughby, J Liu, DJ Foster, B Brigham, CS Theile, ... ChemBioChem 17 (11), 985-989, 2016 | 132 | 2016 |
| A truncated cyclin D1 gene encodes a stable mRNA in a human breast cancer cell line. DE Lebwohl, R Muise-Helmericks, L Sepp-Lorenzino, S Serve, M Timaul, ... Oncogene 9 (7), 1925-1929, 1994 | 123 | 1994 |
| Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases FF Zheng, SD Kuduk, G Chiosis, PN Münster, L Sepp-Lorenzino, ... Cancer research 60 (8), 2090-2094, 2000 | 119 | 2000 |
| Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma B Shi, M Abrams, L Sepp-Lorenzino Journal of Histochemistry & Cytochemistry 61 (12), 901-909, 2013 | 118 | 2013 |
| Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery B Shi, E Keough, A Matter, K Leander, S Young, E Carlini, AB Sachs, ... Journal of Histochemistry & Cytochemistry 59 (8), 727-740, 2011 | 115 | 2011 |
