| Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts K Huhtinen, P Suvitie, J Hiissa, J Junnila, J Huvila, H Kujari, M Setälä, ... British journal of cancer 100 (8), 1315-1319, 2009 | 510 | 2009 |
| Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels K Huhtinen, R Desai, M Ståhle, A Salminen, DJ Handelsman, ... The Journal of Clinical Endocrinology & Metabolism 97 (11), 4228-4235, 2012 | 201 | 2012 |
| The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium B Cloke, K Huhtinen, L Fusi, T Kajihara, M Yliheikkilä, KK Ho, ... Endocrinology 149 (9), 4462-4474, 2008 | 188 | 2008 |
| Fast and sensitive liquid chromatography–mass spectrometry assay for seven androgenic and progestagenic steroids in human serum P Keski-Rahkonen, K Huhtinen, M Poutanen, S Auriola The Journal of steroid biochemistry and molecular biology 127 (3-5), 396-404, 2011 | 134 | 2011 |
| Estrogen biosynthesis and signaling in endometriosis K Huhtinen, M Ståhle, A Perheentupa, M Poutanen Molecular and cellular endocrinology 358 (2), 146-154, 2012 | 120 | 2012 |
| A functional homologous recombination assay predicts primary chemotherapy response and long-term survival in ovarian cancer patients M Tumiati, S Hietanen, J Hynninen, E Pietilä, A Färkkilä, K Kaipio, ... Clinical Cancer Research 24 (18), 4482-4493, 2018 | 104 | 2018 |
| Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer K Zhang, EP Erkan, S Jamalzadeh, J Dai, N Andersson, K Kaipio, ... Science advances 8 (8), eabm1831, 2022 | 93 | 2022 |
| Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy S Iyer, S Zhang, S Yucel, H Horn, SG Smith, F Reinhardt, E Hoefsmit, ... Cancer Discovery 11 (2), 384-407, 2021 | 82 | 2021 |
| Evaluation of inhibitors for 17β-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme B Husen, K Huhtinen, M Poutanen, L Kangas, J Messinger, H Thole Molecular and cellular endocrinology 248 (1-2), 109-113, 2006 | 81 | 2006 |
| DNA methylation and transcriptome changes associated with cisplatin resistance in ovarian cancer RJ Lund, K Huhtinen, J Salmi, J Rantala, EV Nguyen, R Moulder, ... Scientific reports 7 (1), 1469, 2017 | 76 | 2017 |
| Human hydroxysteroid (17-β) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts B Husen, K Huhtinen, T Saloniemi, J Messinger, HH Thole, M Poutanen Endocrinology 147 (11), 5333-5339, 2006 | 75 | 2006 |
| The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid α/β hydrolase K Huhtinen, J O'Byrne, PJG Lindquist, JA Contreras, SEH Alexson Journal of Biological Chemistry 277 (5), 3424-3432, 2002 | 72 | 2002 |
| Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions K Huhtinen, T Saloniemi-Heinonen, P Keski-Rahkonen, R Desai, ... The Journal of Clinical Endocrinology & Metabolism 99 (11), E2188-E2197, 2014 | 70 | 2014 |
| LC‐MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure … P Keski‐Rahkonen, K Huhtinen, R Desai, D Tim Harwood, ... Journal of Mass Spectrometry 48 (9), 1050-1058, 2013 | 69 | 2013 |
| Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women M Hallamaa, P Suvitie, K Huhtinen, J Matomäki, M Poutanen, ... Gynecologic oncology 125 (3), 667-672, 2012 | 69 | 2012 |
| Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core A Lilienkampf, S Karkola, S Alho-Richmond, P Koskimies, N Johansson, ... Journal of medicinal chemistry 52 (21), 6660-6671, 2009 | 52 | 2009 |
| Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes Y Lee, SR Sooranna, V Terzidou, M Christian, J Brosens, K Huhtinen, ... Journal of cellular and molecular medicine 16 (10), 2487-2503, 2012 | 46 | 2012 |
| A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions M Gabriel, V Fey, T Heinosalo, P Adhikari, K Rytkönen, T Komulainen, ... Scientific data 7 (1), 284, 2020 | 45 | 2020 |
| ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors K Kaipio, P Chen, P Roering, K Huhtinen, P Mikkonen, P Östling, ... The Journal of pathology 250 (2), 159-169, 2020 | 45 | 2020 |
| Identification of prognostic groups in high-grade serous ovarian cancer treated with platinum–taxane chemotherapy P Chen, K Huhtinen, K Kaipio, P Mikkonen, V Aittomäki, R Lindell, ... Cancer research 75 (15), 2987-2998, 2015 | 42 | 2015 |
