T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis MT Ferretti, M Merlini, C Späni, C Gericke, N Schweizer, G Enzmann, ... Brain, behavior, and immunity 54, 211-225, 2016 | 169 | 2016 |
Sex-related responses after traumatic brain injury: Considerations for preclinical modeling CB Späni, DJ Braun, LJ Van Eldik Frontiers in neuroendocrinology 50, 52-66, 2018 | 167 | 2018 |
A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis M Maier, T Welt, F Wirth, F Montrasio, D Preisig, J McAfoose, FG Vieira, ... Science translational medicine 10 (470), eaah3924, 2018 | 83 | 2018 |
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells C Späni, T Suter, R Derungs, MT Ferretti, T Welt, F Wirth, C Gericke, ... Acta neuropathologica communications 3, 1-14, 2015 | 82 | 2015 |
Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation L Kulic, J McAfoose, T Welt, C Tackenberg, C Späni, F Wirth, V Finder, ... Translational psychiatry 2 (11), e183-e183, 2012 | 54 | 2012 |
High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders DF Preisig, L Kulic, M Krüger, F Wirth, J McAfoose, C Späni, P Gantenbein, ... Behavioural brain research 311, 340-353, 2016 | 50 | 2016 |
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age-and sex-related differences over the adult life span K Rauen, CB Späni, MC Tartaglia, MT Ferretti, L Reichelt, P Probst, ... Geroscience 43, 263-278, 2021 | 35 | 2021 |
Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease R Derungs, GG Camici, RD Spescha, T Welt, C Tackenberg, C Späni, ... Molecular psychiatry 22 (4), 605-614, 2017 | 35 | 2017 |
Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease M Hanenberg, J McAfoose, L Kulic, T Welt, F Wirth, P Parizek, L Strobel, ... Journal of Biological Chemistry 289 (39), 27080-27089, 2014 | 35 | 2014 |
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes Z Zhou, AD Bachstetter, CB Späni, SM Roy, DM Watterson, LJ Van Eldik Journal of neuroinflammation 14, 1-12, 2017 | 29 | 2017 |
Acute effects of muscarinic M1 receptor modulation on AβPP metabolism and amyloid-β levels in vivo: a microdialysis study T Welt, L Kulic, SE Hoey, J McAfoose, C Späni, AS Chadha, A Fisher, ... Journal of Alzheimer's Disease 46 (4), 971-982, 2015 | 25 | 2015 |
The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease B Bac, C Hicheri, C Weiss, A Buell, N Vilcek, C Spaeni, C Geula, ... Neurobiology of aging 123, 98-110, 2023 | 14 | 2023 |
Modulation of neuroimmune systems to preserve brain function in aging and dementia DJ Braun, EM Weekman, MN Gordon, CB Späni Frontiers in Neuroscience 16, 995409, 2022 | | 2022 |
ROLE OF THE ADAPTIVE IMMUNE SYSTEM IN CEREBRAL BETA-AMYLOIDOSIS L Kulic, C Spaeni, C Cervia, T Suter, MT Ferretti, C Gericke, T Welt, ... Alzheimer's & Dementia 7 (12), P362, 2016 | | 2016 |
Role of the adaptive immune system in the pathogenesis of Alzheimer's disease C Späni University of Zurich, 2015 | | 2015 |
P2‐374: Effects of anti‐TNF therapy on amyloid pathology and neuroinflammation in 12‐month‐old arcAß transgenic mice J McAfoose, L Kulic, T Welt, C Späni, R Derungs, A Pfister, R Nitsch Alzheimer's & Dementia 8 (4S_Part_11), P394-P394, 2012 | | 2012 |
O4‐07‐02: A novel mouse model of intraneuronal oligomers and congophilic amyloid angiopathy L Kulic, J McAfoose, T Welt, C Späni, F Wirth, C Hock, R Nitsch Alzheimer's & Dementia 8 (4S_Part_17), P627-P627, 2012 | | 2012 |
Effects of functional lymphocyte ablation in a mouse model of Alzheimer’s C Späni, T Suter, MT Ferretti, R Derungs, F Wirth, T Welt, C Hock, ... Psychiatry 68, 71-78, 0 | | |