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Pathum Weerawarna
Pathum Weerawarna
Assistant Research Professor of Medicine
在 iu.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Antifungal drug discovery: the process and outcomes
R Calderone, N Sun, F Gay-Andrieu, W Groutas, P Weerawarna, ...
Future microbiology 9 (6), 791-805, 2014
1102014
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator …
JI Juncosa, K Takaya, HV Le, MJ Moschitto, PM Weerawarna, ...
Journal of the American Chemical Society 140 (6), 2151-2164, 2018
762018
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
SR Mandadapu, PM Weerawarna, MR Gunnam, KR Alliston, ...
Bioorganic & medicinal chemistry letters 22 (14), 4820-4826, 2012
712012
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure–activity relationships and biochemical, X-ray crystallographic, cell …
AC Galasiti Kankanamalage, Y Kim, PM Weerawarna, RAZ Uy, ...
Journal of medicinal chemistry 58 (7), 3144-3155, 2015
612015
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
SR Mandadapu, PM Weerawarna, AM Prior, RAZ Uy, S Aravapalli, ...
Bioorganic & medicinal chemistry letters 23 (13), 3709-3712, 2013
612013
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
PM Weerawarna, Y Kim, ACG Kankanamalage, VC Damalanka, ...
European journal of medicinal chemistry 119, 300-318, 2016
402016
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
VC Damalanka, Y Kim, KR Alliston, PM Weerawarna, ...
Journal of medicinal chemistry 59 (5), 1899-1913, 2016
352016
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides
Y Kim, ACG Kankanamalage, VC Damalanka, PM Weerawarna, ...
Antiviral research 125, 84-91, 2016
312016
A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid
W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ...
Journal of the American Chemical Society 142 (10), 4892-4903, 2020
282020
Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors
ACG Kankanamalage, Y Kim, AD Rathnayake, VC Damalanka, ...
European journal of medicinal chemistry 126, 502-516, 2017
232017
Anti-norovirus therapeutics: a patent review (2010-2015)
AC Galasiti Kankanamalage, PM Weerawarna, Y Kim, KO Chang, ...
Expert opinion on therapeutic patents 26 (3), 297-308, 2016
162016
Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine …
W Zhu, PF Doubleday, A Butrin, PM Weerawarna, RD Melani, DS Catlin, ...
Journal of the American Chemical Society 143 (21), 8193-8207, 2021
152021
Mechanism-based design of 3-amino-4-halocyclopentenecarboxylic acids as inactivators of GABA aminotransferase
S Shen, PF Doubleday, PM Weerawarna, W Zhu, NL Kelleher, ...
ACS Medicinal Chemistry Letters 11 (10), 1949-1955, 2020
112020
Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease
AC Galasiti Kankanamalage, PM Weerawarna, AD Rathnayake, Y Kim, ...
Proteins: Structure, Function, and Bioinformatics 87 (7), 579-587, 2019
102019
In Vitro Antibacterial Activity of 4-Phenyl-1-(2-phenyl-allyl) pyridinium bromide: A Novel Class of Pyridinium Based Antibacterial Compounds
RN Jayatissa, RP Perera, CM Hettiarachchi, PM Weerawarna
Indian journal of microbiology 52, 83-87, 2012
92012
Theoretical and mechanistic validation of global kinetic parameters of the inactivation of GABA aminotransferase by OV329 and CPP-115
PM Weerawarna, MJ Moschitto, RB Silverman
ACS chemical biology 16 (4), 615-630, 2021
62021
Lyn Kinase Structure, Regulation, and Involvement in Neurodegenerative Diseases: A Mini Review
PM Weerawarna, TI Richardson
Kinases and Phosphatases 1 (1), 23-38, 2023
42023
Synthesis of (2R,4S)-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction
AO Dukes, PM Weerawarna, AN Devitt, RB Silverman
The Journal of Organic Chemistry, 2024
22024
Main Proteases of Key RNA Viruses, Including Coronavirus, Recognize P2 Residues in the Polyproline Type II Conformation: Harnessing Proline's Unique Conformation for Protease …
P Weerawarna
12023
Identification of Chemical Tool Compounds to Investigate the Role of Lyn Kinase in TREM2-Mediated Microglia Activation and Phagocytosis
PM Weerawarna, MT Robo, S Chu, ER Mason, C Davis, SP Angus, ...
Alzheimer's Association International Conference, 2024
2024
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