Antifungal drug discovery: the process and outcomes R Calderone, N Sun, F Gay-Andrieu, W Groutas, P Weerawarna, ... Future microbiology 9 (6), 791-805, 2014 | 110 | 2014 |
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator … JI Juncosa, K Takaya, HV Le, MJ Moschitto, PM Weerawarna, ... Journal of the American Chemical Society 140 (6), 2151-2164, 2018 | 76 | 2018 |
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles SR Mandadapu, PM Weerawarna, MR Gunnam, KR Alliston, ... Bioorganic & medicinal chemistry letters 22 (14), 4820-4826, 2012 | 71 | 2012 |
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure–activity relationships and biochemical, X-ray crystallographic, cell … AC Galasiti Kankanamalage, Y Kim, PM Weerawarna, RAZ Uy, ... Journal of medicinal chemistry 58 (7), 3144-3155, 2015 | 61 | 2015 |
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus SR Mandadapu, PM Weerawarna, AM Prior, RAZ Uy, S Aravapalli, ... Bioorganic & medicinal chemistry letters 23 (13), 3709-3712, 2013 | 61 | 2013 |
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies PM Weerawarna, Y Kim, ACG Kankanamalage, VC Damalanka, ... European journal of medicinal chemistry 119, 300-318, 2016 | 40 | 2016 |
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease VC Damalanka, Y Kim, KR Alliston, PM Weerawarna, ... Journal of medicinal chemistry 59 (5), 1899-1913, 2016 | 35 | 2016 |
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides Y Kim, ACG Kankanamalage, VC Damalanka, PM Weerawarna, ... Antiviral research 125, 84-91, 2016 | 31 | 2016 |
A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ... Journal of the American Chemical Society 142 (10), 4892-4903, 2020 | 28 | 2020 |
Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors ACG Kankanamalage, Y Kim, AD Rathnayake, VC Damalanka, ... European journal of medicinal chemistry 126, 502-516, 2017 | 23 | 2017 |
Anti-norovirus therapeutics: a patent review (2010-2015) AC Galasiti Kankanamalage, PM Weerawarna, Y Kim, KO Chang, ... Expert opinion on therapeutic patents 26 (3), 297-308, 2016 | 16 | 2016 |
Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine … W Zhu, PF Doubleday, A Butrin, PM Weerawarna, RD Melani, DS Catlin, ... Journal of the American Chemical Society 143 (21), 8193-8207, 2021 | 15 | 2021 |
Mechanism-based design of 3-amino-4-halocyclopentenecarboxylic acids as inactivators of GABA aminotransferase S Shen, PF Doubleday, PM Weerawarna, W Zhu, NL Kelleher, ... ACS Medicinal Chemistry Letters 11 (10), 1949-1955, 2020 | 11 | 2020 |
Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease AC Galasiti Kankanamalage, PM Weerawarna, AD Rathnayake, Y Kim, ... Proteins: Structure, Function, and Bioinformatics 87 (7), 579-587, 2019 | 10 | 2019 |
In Vitro Antibacterial Activity of 4-Phenyl-1-(2-phenyl-allyl) pyridinium bromide: A Novel Class of Pyridinium Based Antibacterial Compounds RN Jayatissa, RP Perera, CM Hettiarachchi, PM Weerawarna Indian journal of microbiology 52, 83-87, 2012 | 9 | 2012 |
Theoretical and mechanistic validation of global kinetic parameters of the inactivation of GABA aminotransferase by OV329 and CPP-115 PM Weerawarna, MJ Moschitto, RB Silverman ACS chemical biology 16 (4), 615-630, 2021 | 6 | 2021 |
Lyn Kinase Structure, Regulation, and Involvement in Neurodegenerative Diseases: A Mini Review PM Weerawarna, TI Richardson Kinases and Phosphatases 1 (1), 23-38, 2023 | 4 | 2023 |
Synthesis of (2R,4S)-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction AO Dukes, PM Weerawarna, AN Devitt, RB Silverman The Journal of Organic Chemistry, 2024 | 2 | 2024 |
Main Proteases of Key RNA Viruses, Including Coronavirus, Recognize P2 Residues in the Polyproline Type II Conformation: Harnessing Proline's Unique Conformation for Protease … P Weerawarna | 1 | 2023 |
Identification of Chemical Tool Compounds to Investigate the Role of Lyn Kinase in TREM2-Mediated Microglia Activation and Phagocytosis PM Weerawarna, MT Robo, S Chu, ER Mason, C Davis, SP Angus, ... Alzheimer's Association International Conference, 2024 | | 2024 |