BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, O Shalem, ... Nature 527 (7577), 192-197, 2015 | 976 | 2015 |
Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies DS Vinjamur, DE Bauer, SH Orkin British journal of haematology 180 (5), 630-643, 2018 | 121 | 2018 |
Synthetic lethality of Wnt pathway activation and asparaginase in drug-resistant acute leukemias L Hinze, M Pfirrmann, S Karim, J Degar, C McGuckin, D Vinjamur, ... Cancer cell 35 (4), 664-676. e7, 2019 | 104 | 2019 |
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis F Sher, M Hossain, D Seruggia, VAC Schoonenberg, Q Yao, P Cifani, ... Nature genetics 51 (7), 1149-1159, 2019 | 100 | 2019 |
Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal β-globin genes through direct promoter binding YN Alhashem, DS Vinjamur, M Basu, U Klingmüller, KML Gaensler, ... Journal of Biological Chemistry 286 (28), 24819-24827, 2011 | 61 | 2011 |
ZNF410 represses fetal globin by singular control of CHD4 DS Vinjamur, Q Yao, MA Cole, C McGuckin, C Ren, J Zeng, M Hossain, ... Nature genetics 53 (5), 719-728, 2021 | 54 | 2021 |
Growing and genetically manipulating human umbilical cord blood-derived erythroid progenitor (HUDEP) cell lines DS Vinjamur, DE Bauer Erythropoiesis: Methods and Protocols, 275-284, 2018 | 50 | 2018 |
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits A Choudhuri, E Trompouki, BJ Abraham, LM Colli, KH Kock, W Mallard, ... Nature genetics 52 (12), 1333-1345, 2020 | 31 | 2020 |
Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation DS Vinjamur, KJ Wade, SF Mohamad, JL Haar, ST Sawyer, JA Lloyd Haematologica 99 (10), 1565, 2014 | 27 | 2014 |
Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies B Liu, C Brendel, DS Vinjamur, Y Zhou, C Harris, M McGuinness, ... Molecular Therapy 30 (8), 2693-2708, 2022 | 24 | 2022 |
Krüppel-like transcription factor KLF1 is required for optimal γ-and β-globin expression in human fetal erythroblasts DS Vinjamur, YN Alhashem, SF Mohamad, P Amin, DC Williams Jr, ... PLoS One 11 (2), e0146802, 2016 | 20 | 2016 |
Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency MW Wessels, MH Cnossen, TB van Dijk, N Gillemans, KLJ Schmidt, ... Blood advances 5 (9), 2339-2349, 2021 | 13 | 2021 |
Crispr-Cas9 saturating mutagenesis reveals an Achilles heel in the BCL11A erythroid enhancer for fetal hemoglobin induction (by genome editing) DE Bauer, MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, ... Blood 126 (23), 638, 2015 | 7 | 2015 |
Synthetic lethality of wnt pathway activation and asparaginase in drug-resistant acute leukemias L Hinze, M Pfirrmann, S Karim, J Degar, C McGuckin, D Vinjamur, ... Blood, The Journal of the American Society of Hematology 132 (Supplement 1 …, 2018 | 1 | 2018 |
IGF2BP1 Orchestrates Post-Transcriptional Control of Globin Switching through Direct Binding to Globins and Their Regulators S Coyne, T Wu, D Vinjamur, M Hossain, DE Bauer Blood 144 (Supplement 1), 414-414, 2024 | | 2024 |
Targeting znf410 for fetal hemoglobin induction in betahemoglobinopathies DE Bauer, D Vinjamur US Patent App. 18/016,190, 2023 | | 2023 |
Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat beta-hemoglobinopathies B Liu, C Brendel, DS Vinjamur, C Harris, M McGuinness, H Xu, DE Bauer, ... HUMAN GENE THERAPY 32 (19-20), A58-A58, 2021 | | 2021 |
ZNF410 represses fetal globin by devoted control of CHD4/NuRD [preprint] DS Vinjamur, Q Yao, MA Cole, C McGuckin, C Ren, J Zeng, M Hossain, ... | | 2020 |
S859 GENOME‐WIDE CRISPR‐CAS9 SCREEN REVEALS SYNTHETIC LETHALITY OF WNT PATHWAY ACTIVATION AND ASPARAGINASE IN DRUG‐RESISTANT ACUTE LEUKEMIAS L Hinze, M Pfirrmann, S Karim, J Degar, C McGuckin, D Vinjamur, ... HemaSphere 3, 384, 2019 | | 2019 |
Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations Y Wu, MA Cole, A Mousas, J Zeng, Q Yao, D Vinjamur, R Kurita, ... Blood 132, 532, 2018 | | 2018 |