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Menelas Pangalos
Menelas Pangalos
AstraZeneca R&D (retired)
在 astrazeneca.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
D Cook, D Brown, R Alexander, R March, P Morgan, G Satterthwaite, ...
Nature reviews Drug discovery 13 (6), 419-431, 2014
13842014
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
JS Jacobsen, CC Wu, JM Redwine, TA Comery, R Arias, M Bowlby, ...
Proceedings of the National Academy of Sciences 103 (13), 5161-5166, 2006
8452006
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger, B Ravikumar, FM Menzies, LG Oroz, BR Underwood, ...
Human molecular genetics 15 (3), 433-442, 2006
8262006
Intramuscular AZD7442 (tixagevimab–cilgavimab) for prevention of Covid-19
MJ Levin, A Ustianowski, S De Wit, O Launay, M Avila, A Templeton, ...
New England Journal of Medicine 386 (23), 2188-2200, 2022
6642022
Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 vaccine
AR Falsey, ME Sobieszczyk, I Hirsch, S Sproule, ML Robb, L Corey, ...
New England Journal of Medicine 385 (25), 2348-2360, 2021
6342021
Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory
F Liu, M Day, LC Muniz, D Bitran, R Arias, R Revilla-Sanchez, S Grauer, ...
Nature neuroscience 11 (3), 334-343, 2008
5642008
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice
Y Gao, DV Vasilyev, MB Goncalves, FV Howell, C Hobbs, M Reisenberg, ...
Journal of Neuroscience 30 (6), 2017-2024, 2010
5422010
Drug development for CNS disorders: strategies for balancing risk and reducing attrition
MN Pangalos, LE Schechter, O Hurko
Nature Reviews Drug Discovery 6 (7), 521-532, 2007
4232007
Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival
C Jaillard, S Harrison, B Stankoff, MS Aigrot, AR Calver, G Duddy, ...
Journal of Neuroscience 25 (6), 1459-1469, 2005
4222005
Impact of a five-dimensional framework on R&D productivity at AstraZeneca
P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ...
Nature reviews Drug discovery 17 (3), 167-181, 2018
4002018
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
AD Medhurst, G Rennie, CG Chapman, H Meadows, MD Duckworth, ...
Molecular brain research 86 (1-2), 101-114, 2001
3872001
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels
DR Riddell, H Zhou, K Atchison, HK Warwick, PJ Atkinson, J Jefferson, ...
Journal of Neuroscience 28 (45), 11445-11453, 2008
3822008
GABAB receptors: a new paradigm in G protein signaling
A Couve, SJ Moss, MN Pangalos
Molecular and Cellular Neuroscience 16 (4), 296-312, 2000
3702000
mRNA distribution analysis of human TRPC family in CNS and peripheral tissues
A Riccio, AD Medhurst, C Mattei, RE Kelsell, AR Calver, AD Randall, ...
Molecular brain research 109 (1-2), 95-104, 2002
3692002
Epileptogenesis and enhanced prepulse inhibition in GABAB1-deficient mice
HM Prosser, CH Gill, WD Hirst, E Grau, M Robbins, A Calver, EM Soffin, ...
Molecular and Cellular Neuroscience 17 (6), 1059-1070, 2001
3362001
The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models
AD Medhurst, DC Harrison, SJ Read, CA Campbell, MJ Robbins, ...
Journal of neuroscience methods 98 (1), 9-20, 2000
3232000
The clustering of GABAA receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor α2 subunits to gephyrin
V Tretter, TC Jacob, J Mukherjee, JM Fritschy, MN Pangalos, SJ Moss
Journal of Neuroscience 28 (6), 1356-1365, 2008
3082008
The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
DR Riddell, H Zhou, TA Comery, E Kouranova, CF Lo, HK Warwick, ...
Molecular and Cellular Neuroscience 34 (4), 621-628, 2007
2842007
Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease
TA Comery, RL Martone, S Aschmies, KP Atchison, G Diamantidis, ...
Journal of Neuroscience 25 (39), 8898-8902, 2005
2752005
GABAB2 is essential for G-protein coupling of the GABAB receptor heterodimer
MJ Robbins, AR Calver, AK Filippov, WD Hirst, RB Russell, MD Wood, ...
Journal of Neuroscience 21 (20), 8043-8052, 2001
2702001
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