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Mark Petersen
Mark Petersen
Zymeworks
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引用次数
引用次数
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A helping hand to overcome solubility challenges in chemical protein synthesis
MT Jacobsen, ME Petersen, X Ye, M Galibert, GH Lorimer, V Aucagne, ...
Journal of the American Chemical Society 138 (36), 11775-11782, 2016
812016
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential …
N Kedei, A Telek, AM Michalowski, MB Kraft, W Li, YB Poudel, A Rudra, ...
Biochemical pharmacology 85 (3), 313-324, 2013
232013
Synthesis of tumor necrosis factor α for use as a mirror-image phage display target
ME Petersen, MT Jacobsen, MS Kay
Organic & biomolecular chemistry 14 (23), 5298-5303, 2016
212016
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy
MM Disotuar, ME Petersen, JM Nogueira, MS Kay, DHC Chou
Organic & biomolecular chemistry 17 (7), 1703-1708, 2019
202019
Synthetic ingenols maximize protein kinase C-induced HIV-1 latency reversal
AM Spivak, RA Nell, M Petersen, L Martins, P Sebahar, RE Looper, ...
Antimicrobial agents and chemotherapy 62 (11), 10.1128/aac. 01361-18, 2018
192018
Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag
JM Fulcher, ME Petersen, RJ Giesler, ZS Cruz, DM Eckert, JN Francis, ...
Organic & biomolecular chemistry 17 (48), 10237-10244, 2019
152019
Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin
JS Kelsey, C Cataisson, J Chen, MA Herrmann, ME Petersen, ...
Molecular carcinogenesis 55 (12), 2183-2195, 2016
82016
Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates
MG Brant, GAE Garnett, J Guedia, M Lasalle, S Lawn, ME Petersen, ...
Bioorganic & Medicinal Chemistry Letters 91, 129348, 2023
52023
Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands
N Kedei, JQ Chen, MA Herrmann, A Telek, PK Goldsmith, ME Petersen, ...
Journal of Medicinal Chemistry 57 (12), 5356-5369, 2014
52014
Replacement of the bryostatin A-and B-pyran rings with phenyl rings leads to loss of high affinity binding with PKC
ME Petersen, N Kedei, NE Lewin, PM Blumberg, GE Keck
Tetrahedron letters 57 (42), 4749-4753, 2016
42016
Synthesis and biological evaluation of fluorescent bryostatin analogues
TJ Cummins, N Kedei, A Czikora, NE Lewin, S Kirk, ME Petersen, ...
ChemBioChem 19 (8), 877-889, 2018
32018
Design and evaluation of ZD06519, a novel camptothecin payload for antibody drug conjugates
ME Petersen, MG Brant, M Lasalle, S Das, R Duan, J Wong, T Ding, ...
Molecular Cancer Therapeutics 23 (5), 606-618, 2024
12024
Structure–Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody–Drug Conjugate Payloads
ME Petersen, MG Brant, M Lasalle, VKC Fung, AH Rojas, J Wong, S Das, ...
Journal of Medicinal Chemistry 66 (12), 8288-8309, 2023
12023
Bryostatin analogs and use thereof as antiviral agents
GE Keck, MB Kraft, AP Truong, CC Sanchez, W Li, JA Covel, D Welch, ...
US Patent App. 15/503,495, 2017
12017
Synthesis of structurally simplified bryostatin analogues: Probing the underlying biology and progressing towards more ‘drug like’compounds
ME Petersen
Ph. D. Thesis, University of Utah, Salt Lake City, UT, 2014.[Google Scholar], 2014
12014
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential …
N Kedei, A Telek, AM Michalowski, MB Kraft, W Li, YB Poudel, A Rudra, ...
Cancer Research 72 (8_Supplement), 3815-3815, 2012
12012
Development of three-dimensional cancer cell line spheroid models for the in vitro functional characterization of cytotoxic antibody-drug conjugates
J Wong, AH Rojas, A Bissessur, LT Degefie, AP Sagoe-Wagner, S Das, ...
Cancer Research 84 (6_Supplement), 3127-3127, 2024
2024
ZW191-a FRα-targeting antibody drug conjugate with strong preclinical activity across multiple FRα-expressing indications
S Lawn, AH Rojas, R Colombo, J Wong, K Wu, V Fung, M Lasalle, ...
Cancer Research 84 (6_Supplement), 1862-1862, 2024
2024
ZW251, a novel Glypican 3-targeting antibody drug conjugate bearing a topoisomerase I inhibitor payload
L Madera, AH Rojas, R Colombo, A Wu, CL Piscitelli, D Urosev, ...
Cancer Research 83 (7_Supplement), 2658-2658, 2023
2023
ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload
AH Rojas, J Wong, D Urosev, S Lawn, K Wu, S Konomura, M Lasalle, ...
Cancer Research 83 (7_Supplement), 1533-1533, 2023
2023
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