| Acetylation of the p53 DNA-binding domain regulates apoptosis induction SM Sykes, HS Mellert, MA Holbert, K Li, R Marmorstein, WS Lane, ... Molecular cell 24 (6), 841-851, 2006 | 876 | 2006 |
| Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor EM Bowers, G Yan, C Mukherjee, A Orry, L Wang, MA Holbert, NT Crump, ... Chemistry & biology 17 (5), 471-482, 2010 | 723 | 2010 |
| Structure and activity of enzymes that remove histone modifications MA Holbert, R Marmorstein Current opinion in structural biology 15 (6), 673-680, 2005 | 157 | 2005 |
| Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation R Huang, MA Holbert, MK Tarrant, S Curtet, DR Colquhoun, BM Dancy, ... Journal of the American Chemical Society 132 (29), 9986-9987, 2010 | 133 | 2010 |
| Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP Y Tang, MA Holbert, H Wurtele, K Meeth, W Rocha, M Gharib, E Jiang, ... Nature structural & molecular biology 15 (7), 738-745, 2008 | 132 | 2008 |
| Protein tyrosine kinase–substrate interactions R Bose, MA Holbert, KA Pickin, PA Cole Current opinion in structural biology 16 (6), 668-675, 2006 | 73 | 2006 |
| The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting MA Holbert, T Sikorski, J Carten, D Snowflack, S Hodawadekar, ... Journal of Biological Chemistry 282 (50), 36603-36613, 2007 | 65 | 2007 |
| Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation Y Tang, MA Holbert, N Delgoshaie, H Wurtele, B Guillemette, K Meeth, ... Structure 19 (2), 221-231, 2011 | 56 | 2011 |
| High-throughput cellular thermal shift assays in research and drug discovery MJ Henderson, MA Holbert, A Simeonov, LA Kallal SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 137-147, 2020 | 49 | 2020 |
| A high-throughput dose-response cellular thermal shift assay for rapid screening of drug target engagement in living cells, exemplified using SMYD3 and IDO1 DE McNulty, WG Bonnette, H Qi, L Wang, TF Ho, A Waszkiewicz, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (1), 34-46, 2018 | 47 | 2018 |
| De Novo Discovery of Serotonin N-Acetyltransferase Inhibitors LM Szewczuk, SA Saldanha, S Ganguly, EM Bowers, M Javoroncov, ... Journal of medicinal chemistry 50 (22), 5330-5338, 2007 | 43 | 2007 |
| An Fc Domain Protein–Small Molecule Conjugate as an Enhanced Immunomodulator MJ Chiang, MA Holbert, JH Kalin, YH Ahn, J Giddens, MN Amin, ... Journal of the American Chemical Society 136 (9), 3370-3373, 2014 | 37 | 2014 |
| Nucleosome binding alters the substrate bonding environment of histone H3 lysine 36 methyltransferase NSD2 MB Poulin, JL Schneck, RE Matico, W Hou, PJ McDevitt, M Holbert, ... Journal of the American Chemical Society 138 (21), 6699-6702, 2016 | 14 | 2016 |
| Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells Y Jiang, J Wang, G Zhang, K Oza, L Myers, MA Holbert, S Sweitzer Protein Expression and Purification 97, 9-16, 2014 | 4 | 2014 |
| Modular protein Ligation: A new paradigm as a Reagent platform for pre-clinical Drug Discovery R Matico, LM Szewczuk, B Pietrak, S Chen, E Dul, WG Bonnette, ... Scientific Reports 9 (1), 1-11, 2019 | 3 | 2019 |
| Development of a high-content imaging assay for screening compound aggregation Y Jiang, A Hoffman, G Quinque, WG Bonnette, LM Szewczuk, MA Holbert, ... Analytical biochemistry 559, 30-33, 2018 | 1 | 2018 |
| Supplementary methods ZY Huang, MA Holbert, MK Tarrant, S Curtet, DR Colquhoun, BM Dancy, ... Ann Rheum Dis 646, 79, 2020 | | 2020 |
| Structure and chemistry of the human p300/CBP and yeast Rtt109 histone acetyltransferase Y Tang, X Liu, L Wang, MA Holbert, K Meeth, H Wurtele, W Rocha, ... The FASEB Journal 23, 89.2-89.2, 2009 | | 2009 |
| hMOF-mediated acetylation enhances cytoplasmic levels of p53 protein SM Sykes, JJ Lee, MA Holbert, R Marmorstein, WS Lane, SB McMahon CANCER RESEARCH 66 (8), 2006 | | 2006 |
| DNA recognition by the MYST family of histone acetyltransferases: Structure/function characterization of the human monocytic leukemia zinc finger protein MOZ M Holbert University of Pennsylvania, 2006 | | 2006 |
