| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells U Putz, J Howitt, A Doan, CP Goh, LH Low, J Silke, SS Tan Science signaling 5 (243), ra70-ra70, 2012 | 333 | 2012 |
| Engineered exosomes as vehicles for biologically active proteins U Sterzenbach, U Putz, LH Low, J Silke, SS Tan, J Howitt Molecular Therapy 25 (6), 1269-1278, 2017 | 307 | 2017 |
| Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor Y He, PR Chipman, J Howitt, CM Bator, MA Whitt, TS Baker, RJ Kuhn, ... Nature structural biology 8 (10), 874-878, 2001 | 286 | 2001 |
| Exosomes in the pathology of neurodegenerative diseases J Howitt, AF Hill Journal of Biological Chemistry 291 (52), 26589-26597, 2016 | 255 | 2016 |
| Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins U Putz, J Howitt, J Lackovic, N Foot, S Kumar, J Silke, SS Tan Journal of Biological Chemistry 283 (47), 32621-32627, 2008 | 164 | 2008 |
| Protein aggregation during overexpression limited by peptide extensions with large net negative charge YB Zhang, J Howitt, S McCorkle, P Lawrence, K Springer, P Freimuth Protein expression and purification 36 (2), 207-216, 2004 | 164 | 2004 |
| Binding site for Robo receptors revealed by dissection of the leucine‐rich repeat region of Slit JA Howitt, NJ Clout, E Hohenester The EMBO journal 23 (22), 4406-4412, 2004 | 151 | 2004 |
| Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons J Howitt, U Putz, J Lackovic, A Doan, L Dorstyn, H Cheng, B Yang, ... Proceedings of the National Academy of Sciences 106 (36), 15489-15494, 2009 | 128 | 2009 |
| A molecular mechanism for the heparan sulfate dependence of slit-robo signaling SA Hussain, M Piper, N Fukuhara, L Strochlic, G Cho, JA Howitt, Y Ahmed, ... Journal of Biological Chemistry 281 (51), 39693-39698, 2006 | 122 | 2006 |
| Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia J Howitt, J Lackovic, LH Low, A Naguib, A Macintyre, CP Goh, ... Journal of Cell Biology 196 (1), 29-36, 2012 | 117 | 2012 |
| Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo N Fukuhara, JA Howitt, SA Hussain, E Hohenester Journal of Biological Chemistry 283 (23), 16226-16234, 2008 | 99 | 2008 |
| Adenovirus interaction with its cellular receptor CAR J Howitt, CW Anderson, P Freimuth Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure …, 2003 | 84 | 2003 |
| BDNF exerts contrasting effects on peripheral myelination of NGF-dependent and BDNF-dependent DRG neurons J Xiao, AW Wong, MM Willingham, SK Kaasinen, IA Hendry, J Howitt, ... Journal of Neuroscience 29 (13), 4016-4022, 2009 | 80 | 2009 |
| P53: a guardian of immunity becomes its saboteur through mutation AD Agupitan, P Neeson, S Williams, J Howitt, S Haupt, Y Haupt International journal of molecular sciences 21 (10), 3452, 2020 | 77 | 2020 |
| Interaction of the guidance molecule Slit with cellular receptors E Hohenester, S Hussain, JA Howitt Biochemical Society Transactions 34 (3), 418-421, 2006 | 70 | 2006 |
| Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury Q Sang, MH Kim, S Kumar, N Bye, MC Morganti-Kossman, J Gunnersen, ... Journal of Neuroscience 26 (27), 7234-7244, 2006 | 60 | 2006 |
| Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis Z Liu, LF Dagley, K Shield‐Artin, SN Young, A Bankovacki, X Wang, ... The EMBO journal 40 (23), e103718, 2021 | 50 | 2021 |
| Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke J Lackovic, J Howitt, JK Callaway, J Silke, P Bartlett, SS Tan Experimental neurology 235 (1), 326-335, 2012 | 38 | 2012 |
| Structural basis for variation in adenovirus affinity for the cellular coxsackievirus and adenovirus receptor J Howitt, MC Bewley, V Graziano, JM Flanagan, P Freimuth Journal of Biological Chemistry 278 (28), 26208-26215, 2003 | 36 | 2003 |
| Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels J Howitt, AM Gysbers, S Ayton, F Carew-Jones, U Putz, DI Finkelstein, ... PloS one 9 (1), e87119, 2014 | 35 | 2014 |
