Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs B Hens, Y Tsume, M Bermejo, P Paixao, MJ Koenigsknecht, JR Baker, ... Molecular pharmaceutics 14 (12), 4281-4294, 2017 | 122 | 2017 |
Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded ‘21st Century BA/BE’project B Hens, PD Sinko, N Job, M Dean, J Al-Gousous, N Salehi, RM Ziff, ... International journal of pharmaceutics 548 (1), 120-127, 2018 | 51 | 2018 |
Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO2–H2CO3 Hydration–Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective p K a Controlling … J Al-Gousous, N Salehi, GE Amidon, RM Ziff, P Langguth, GL Amidon Molecular Pharmaceutics 16 (6), 2626-2635, 2019 | 46 | 2019 |
Hierarchical mass transfer analysis of drug particle dissolution, highlighting the hydrodynamics, pH, particle size, and buffer effects for the dissolution of ionizable and … N Salehi, J Al-Gousous, DM Mudie, GL Amidon, RM Ziff, GE Amidon Molecular Pharmaceutics 17 (10), 3870-3884, 2020 | 35 | 2020 |
Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications J Al-Gousous, H Ruan, JA Blechar, KX Sun, N Salehi, P Langguth, ... European Journal of Pharmaceutics and Biopharmaceutics 139, 47-58, 2019 | 35 | 2019 |
Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate–CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical … J Al-Gousous, KX Sun, DP McNamara, B Hens, N Salehi, P Langguth, ... Molecular pharmaceutics 15 (11), 5291-5301, 2018 | 32 | 2018 |
Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach P Paixão, M Bermejo, B Hens, Y Tsume, J Dickens, K Shedden, N Salehi, ... European Journal of Pharmaceutics and Biopharmaceutics 129, 162-174, 2018 | 31 | 2018 |
Linking the gastrointestinal behavior of ibuprofen with the systemic exposure between and within humans—part 1: fasted state conditions M Bermejo, P Paixão, B Hens, Y Tsume, MJ Koenigsknecht, JR Baker, ... Molecular pharmaceutics 15 (12), 5454-5467, 2018 | 27 | 2018 |
Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis N Salehi, G Kuminek, J Al-Gousous, DC Sperry, DE Greenwood, ... Molecular Pharmaceutics 18 (9), 3326-3341, 2021 | 21 | 2021 |
Linking the gastrointestinal behavior of ibuprofen with the systemic exposure between and within humans—part 2: fed state P Paixão, M Bermejo, B Hens, Y Tsume, J Dickens, K Shedden, N Salehi, ... Molecular pharmaceutics 15 (12), 5468-5478, 2018 | 14 | 2018 |
Evaluating the IVIVC by combining tiny-TIM outputs and compartmental PK model to predict oral exposure for different formulations of ibuprofen PC Chiang, J Liu, K Nagapudi, R Wu, MJ Dolton, N Salehi, G Amidon Journal of Pharmaceutical Sciences 111 (7), 2018-2029, 2022 | 11 | 2022 |
Ultrathin, large-area membrane diffusion cell for ph-dependent simultaneous dissolution and absorption studies PD Sinko, S Harris, N Salehi, PJ Meyer, GL Amidon, GE Amidon Molecular Pharmaceutics 17 (7), 2319-2328, 2020 | 11 | 2020 |
Use of gastrointestinal simulator, mass transport analysis, and absorption simulation to investigate the impact of pH modifiers in mitigating weakly basic drugs’ performance … G Kuminek, N Salehi, NM Waltz, DC Sperry, DE Greenwood, SS Hate, ... Molecular Pharmaceutics 20 (1), 147-158, 2022 | 6 | 2022 |
Mechanistic Mass Transport Modeling of Ionizable Drug Dissolution Under In Vivo-Relevant Buffer and Hydrodynamical Conditions N Salehi, J Al-Gousous, G Amidon, G Amidon, RM Ziff 2019 AIChE Annual Meeting, 2019 | 2 | 2019 |
Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer PD Sinko, N Salehi, T Halseth, PJ Meyer, GL Amidon, RM Ziff, GE Amidon Molecular Pharmaceutics 21 (1), 201-215, 2023 | 1 | 2023 |
Summary of the In Vivo Predictive Dissolution (iPD): Oral Drug Delivery (ODD) Conference 2018 B Hens, J Al-Gousous, K Wang, N Salehi, RM Ziff, Y Tsume, M Bermejo, ... Dissolution Technologies 25 (2), 2018 | 1 | 2018 |
Solubility vs Dissolution in Physiological Bicarbonate Buffer F Claussen, J Al-Gousous, N Salehi, MA Garcia, GL Amidon, P Langguth Pharmaceutical Research, 1-9, 2024 | | 2024 |
Comparative Evaluation of Dissolution Performance in a USP 2 Setup and Alternative Stirrers and Vessel Designs: A Systematic Computational Investigation N Salehi, J Al-Gousous, B Hens, GL Amidon, RM Ziff, GE Amidon Molecular Pharmaceutics 21 (5), 2406-2414, 2024 | | 2024 |
Voices in Molecular Pharmaceutics: Meet Dr. Niloufar Salehi, an Enthusiastic Developer of Physiologically Based Biopharmaceutical Models N Salehi Molecular Pharmaceutics 20 (9), 4342-4343, 2023 | | 2023 |
Drug Delivery Technology Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen PC Chiang, J Liu, K Nagapudi, R Wu, MJ Dolton, N Salehi, G Amidon JOURNAL OF PHARMACEUTICAL SCIENCES 111 (7), 2018-2029, 2022 | | 2022 |