DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA L Tang, M Sheraz, M McGrane, J Chang, JT Guo PLoS pathogens 15 (4), e1007742, 2019 | 83 | 2019 |
Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA M Sheraz, J Cheng, L Tang, J Chang, JT Guo Journal of virology 93 (11), 10.1128/jvi. 02230-18, 2019 | 78 | 2019 |
Activation of stimulator of interferon genes in hepatocytes suppresses the replication of hepatitis B virus F Guo, L Tang, S Shu, M Sehgal, M Sheraz, B Liu, Q Zhao, J Cheng, ... Antimicrobial agents and chemotherapy 61 (10), 10.1128/aac. 00771-17, 2017 | 76 | 2017 |
The current status and future directions of hepatitis B antiviral drug discovery L Tang, Q Zhao, S Wu, J Cheng, J Chang, JT Guo Expert opinion on drug discovery 12 (1), 5-15, 2017 | 68 | 2017 |
A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists B Liu, L Tang, X Zhang, J Ma, M Sehgal, J Cheng, X Zhang, Y Zhou, Y Du, ... Antiviral research 147, 37-46, 2017 | 64 | 2017 |
Discovery and mechanistic study of a novel human-stimulator-of-interferon-genes agonist X Zhang, B Liu, L Tang, Q Su, N Hwang, M Sehgal, J Cheng, J Ma, ... ACS infectious diseases 5 (7), 1139-1149, 2019 | 52 | 2019 |
Virological basis for the cure of chronic hepatitis B J Hu, J Cheng, L Tang, Z Hu, Y Luo, Y Li, T Zhou, J Chang, JT Guo ACS infectious diseases 5 (5), 659-674, 2018 | 52 | 2018 |
Interferon alpha induces multiple cellular proteins that coordinately suppress hepadnaviral covalently closed circular DNA transcription J Cheng, Q Zhao, Y Zhou, L Tang, M Sheraz, J Chang, JT Guo Journal of virology 94 (17), 10.1128/jvi. 00442-20, 2020 | 30 | 2020 |
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases J Hu, L Tang, J Cheng, T Zhou, Y Li, J Chang, Q Zhao, JT Guo Emerging microbes & infections 10 (1), 852-864, 2021 | 25 | 2021 |
Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy Q Zhao, H Liu, L Tang, F Wang, G Tolufashe, J Chang, JT Guo Antiviral research, 105782, 2023 | 8 | 2023 |
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity KL Roche, S Remiszewski, MJ Todd, JL Kulp, L Tang, AV Welsh, AP Barry, ... The Journal of Clinical Investigation 133 (12), 2023 | 8 | 2023 |
Heat shock protein family a member 1 promotes intracellular amplification of hepatitis B virus covalently closed circular DNA L Tang, P An, Q Zhao, CA Winkler, J Chang, JT Guo Journal of virology 97 (1), e01261-22, 2023 | 3 | 2023 |
“PROTAC” modified dihydroquinolizinones (DHQs) that cause degradation of PAPD-5 and inhibition of hepatitis A virus and hepatitis B virus, in vitro Y Li, N Hwang, A Snedeker, SM Lemon, D Noe, L Sun, JA Clement, ... Bioorganic & medicinal chemistry letters 102, 129680, 2024 | 2 | 2024 |
An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity L Tang, S Remiszewski, A Snedeker, LW Chiang, T Shenk Antiviral Research 226, 105888, 2024 | 1 | 2024 |
Role and mechanism of host cellular DNA repair proteins in hepatitis B virus cccDNA biosynthesis L Tang Drexel University, 2019 | | 2019 |