| Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide JL Kim, KA Morgenstern, C Lin, T Fox, MD Dwyer, JA Landro, ... Cell 87 (2), 343-355, 1996 | 1004 | 1996 |
| Platinum-195 NMR kinetic and mechanistic studies of cis-and trans-diamminedichloroplatinum (II) binding to DNA DP Bancroft, CA Lepre, SJ Lippard Journal of the American Chemical Society 112 (19), 6860-6871, 1990 | 676 | 1990 |
| Theory and applications of NMR-based screening in pharmaceutical research CA Lepre, JM Moore, JW Peng Chemical reviews 104 (8), 3641-3676, 2004 | 439 | 2004 |
| The SHAPES strategy: an NMR-based approach for lead generation in drug discovery J Fejzo, CA Lepre, JW Peng, GW Bemis, MA Murcko, JM Moore Chemistry & biology 6 (10), 755-769, 1999 | 356 | 1999 |
| Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism E ter Haar, CM Koth, N Abdul-Manan, L Swenson, JT Coll, JA Lippke, ... Structure 18 (9), 1083-1093, 2010 | 225 | 2010 |
| Interaction of platinum antitumor compounds with DNA CA Lepre, SJ Lippard Nucleic Acids and Molecular Biology 4, 9-38, 1990 | 138 | 1990 |
| High-resolution solution structure of reduced French bean plastocyanin and comparison with the crystal structure of poplar plastocyanin JM Moore, CA Lepre, GP Gippert, WJ Chazin, DA Case, PE Wright Journal of molecular biology 221 (2), 533-555, 1991 | 127 | 1991 |
| Library design for NMR-based screening CA Lepre Drug Discovery Today 6 (3), 133-140, 2001 | 123 | 2001 |
| Crystal structure of the p38α-MAPKAP kinase 2 heterodimer E Ter Haar, P Prabakhar, X Liu, C Lepre Journal of biological chemistry 282 (13), 9733-9739, 2007 | 122 | 2007 |
| Nuclear magnetic resonance-based approaches for lead generation in drug discovery JW Peng, CA Lepre, J Fejzo, N Abdul-Manan, JM Moore Methods in Enzymology 338, 202-230, 2002 | 116 | 2002 |
| Inhibitors of bace G Bhisetti, J Saunders, M Murcko, C Lepre, S Britt, J Come, D Deininger, ... US Patent App. 10/136,576, 2003 | 100 | 2003 |
| 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition JW Cheng, CA Lepre, JM Moore Biochemistry 33 (14), 4093-4100, 1994 | 99 | 1994 |
| Microdrop screening: a rapid method to optimize solvent conditions for NMR spectroscopy of proteins CA Lepre, JM Moore Journal of biomolecular NMR 12, 493-499, 1998 | 83 | 1998 |
| Practical aspects of NMR-based fragment screening CA Lepre Methods in Enzymology 493, 219-239, 2011 | 82 | 2011 |
| Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor JW Cheng, CA Lepre, SP Chambers, JR Fulghum, JA Thomson, ... Biochemistry 32 (35), 9000-9010, 1993 | 82 | 1993 |
| Synthesis and characterization of trans-diamminedichloroplatinum (II) adducts of d (CCTCGAGTCTCC). cntdot. d (GGAGACTCGAGG) CA Lepre, L Chassot, CE Costello, SJ Lippard Biochemistry 29 (3), 811-823, 1990 | 75 | 1990 |
| Application of NMR screening in drug discovery J Fejzo, C Lepre, X Xie Current topics in medicinal chemistry 3 (1), 81-97, 2003 | 71 | 2003 |
| Applications of SHAPES screening in drug discovery CA Lepre, J Peng, J Fejzo, N Abdul-Manan, J Pocas, M Jacobs, X Xie, ... Combinatorial Chemistry & High Throughput Screening 5 (8), 583-590, 2002 | 71 | 2002 |
| Synthesis and proton NMR spectroscopic characterization of trans-[Pt (NH3) 2 [d (ApGpGpCpCpT)-N7-A (1), N7-G (3)]] CA Lepre, KG Strothkamp, SJ Lippard Biochemistry 26 (18), 5651-5657, 1987 | 71 | 1987 |
| Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor CM Koth, N Abdul-Manan, CA Lepre, PJ Connolly, S Yoo, AK Mohanty, ... Biochemistry 49 (9), 1862-1872, 2010 | 50 | 2010 |
