Resveratrol improves health and survival of mice on a high-calorie diet JA Baur, KJ Pearson, NL Price, HA Jamieson, C Lerin, A Kalra, ... Nature 444 (7117), 337-342, 2006 | 5373 | 2006 |
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler, ... science 305 (5682), 390-392, 2004 | 2408 | 2004 |
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function NL Price, AP Gomes, AJY Ling, FV Duarte, A Martin-Montalvo, BJ North, ... Cell metabolism 15 (5), 675-690, 2012 | 1639 | 2012 |
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, ... Science 339 (6116), 211-214, 2013 | 1618 | 2013 |
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging AP Gomes, NL Price, AJY Ling, JJ Moslehi, MK Montgomery, L Rajman, ... Cell 155 (7), 1624-1638, 2013 | 1451 | 2013 |
Metformin improves healthspan and lifespan in mice A Martin-Montalvo, EM Mercken, SJ Mitchell, HH Palacios, PL Mote, ... Nature communications 4 (1), 2192, 2013 | 1449 | 2013 |
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span KJ Pearson, JA Baur, KN Lewis, L Peshkin, NL Price, N Labinskyy, ... Cell metabolism 8 (2), 157-168, 2008 | 1377 | 2008 |
Effects of intermittent fasting on health, aging, and disease R De Cabo, MP Mattson New England Journal of Medicine 381 (26), 2541-2551, 2019 | 1343 | 2019 |
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study JA Mattison, GS Roth, TM Beasley, EM Tilmont, AM Handy, RL Herbert, ... Nature 489 (7415), 318-321, 2012 | 1328 | 2012 |
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival H Yang, T Yang, JA Baur, E Perez, T Matsui, JJ Carmona, DW Lamming, ... Cell 130 (6), 1095-1107, 2007 | 1102 | 2007 |
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice RA Miller, DE Harrison, CM Astle, JA Baur, AR Boyd, R De Cabo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2011 | 976 | 2011 |
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake RM Anson, Z Guo, R de Cabo, T Iyun, M Rios, A Hagepanos, DK Ingram, ... Proceedings of the National Academy of Sciences 100 (10), 6216-6220, 2003 | 927 | 2003 |
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans J Guevara-Aguirre, P Balasubramanian, M Guevara-Aguirre, M Wei, ... Science translational medicine 3 (70), 70ra13-70ra13, 2011 | 848 | 2011 |
Caloric restriction improves health and survival of rhesus monkeys JA Mattison, RJ Colman, TM Beasley, DB Allison, JW Kemnitz, GS Roth, ... Nature communications 8 (1), 14063, 2017 | 832 | 2017 |
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy C Lee, L Raffaghello, S Brandhorst, FM Safdie, G Bianchi, ... Science translational medicine 4 (124), 124ra27-124ra27, 2012 | 805 | 2012 |
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency G López-Lluch, N Hunt, B Jones, M Zhu, H Jamieson, S Hilmer, ... Proceedings of the National Academy of Sciences 103 (6), 1768-1773, 2006 | 790 | 2006 |
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth R Firestein, G Blander, S Michan, P Oberdoerffer, S Ogino, J Campbell, ... PloS one 3 (4), e2020, 2008 | 734 | 2008 |
Mechanisms of vascular aging: new perspectives Z Ungvari, G Kaley, R De Cabo, WE Sonntag, A Csiszar Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2010 | 647 | 2010 |
Interventions to slow aging in humans: are we ready? VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown‐Borg, C Caruso, ... Aging cell 14 (4), 497-510, 2015 | 615 | 2015 |
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 Z Ungvari, Z Bagi, A Feher, FA Recchia, WE Sonntag, K Pearson, ... American Journal of Physiology-Heart and Circulatory Physiology 299 (1), H18-H24, 2010 | 610 | 2010 |