Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ... Nature biotechnology 36 (1), 95-102, 2018 | 256 | 2018 |
Design and validation of new genotypic tools for easy and reliable estimation of HIV tropism before using CCR5 antagonists E Poveda, E Seclén, MM González, F García, N Chueca, A Aguilera, ... Journal of antimicrobial chemotherapy 63 (5), 1006-1010, 2009 | 91 | 2009 |
High sensitivity of specific genotypic tools for detection of X4 variants in antiretroviral-experienced patients suitable to be treated with CCR5 antagonists E Seclén, C Garrido, MM González, J González-Lahoz, C de Mendoza, ... Journal of Antimicrobial Chemotherapy 65 (7), 1486-1492, 2010 | 88* | 2010 |
Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor Z Plaza, V Soriano, E Vispo, M del Mar Gonzalez, P Barreiro, E Seclén, ... Antiviral therapy 17 (5), 921-926, 2012 | 68 | 2012 |
Dynamics of HIV tropism under suppressive antiretroviral therapy: implications for tropism testing in subjects with undetectable viraemia E Seclén, M del Mar González, C De Mendoza, V Soriano, E Poveda Journal of antimicrobial chemotherapy 65 (7), 1493-1496, 2010 | 58 | 2010 |
Impact of baseline HIV-1 tropism on viral response and CD4 cell count gains in HIV-infected patients receiving first-line antiretroviral therapy E Seclén, V Soriano, MM González, L Martín-Carbonero, H Gellermann, ... Journal of Infectious Diseases 204 (1), 139-144, 2011 | 40 | 2011 |
High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor E Seclén, M del Mar González, A Corral, C de Mendoza, V Soriano, ... Aids 24 (3), 467-469, 2010 | 40 | 2010 |
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells GN Llewellyn, E Seclén, S Wietgrefe, S Liu, M Chateau, H Pei, K Perkey, ... Journal of Virology 93 (10), 10.1128/jvi. 02086-18, 2019 | 32 | 2019 |
Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients E Seclén, MM González, M Lapaz, C Rodríguez, J Del Romero, ... Journal of antimicrobial chemotherapy 65 (12), 2502-2504, 2010 | 29 | 2010 |
HLA genes in Mayos population from Northeast Mexico A Arnaiz-Villena, J Moscoso, J Granados, JI Serrano-Vela, A la Pena, ... Current Genomics 8 (7), 466-475, 2007 | 28 | 2007 |
High concordance between the position-specific scoring matrix and geno2pheno algorithms for genotypic interpretation of HIV-1 tropism: V3 length as the major cause of disagreement E Seclén, V Soriano, MM González, S Gómez, A Thielen, E Poveda Journal of clinical microbiology 49 (9), 3380-3382, 2011 | 25 | 2011 |
Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes GL Rogers, C Huang, RDE Clark, E Seclén, HY Chen, PM Cannon Molecular Therapy-Methods & Clinical Development 23, 198-209, 2021 | 23 | 2021 |
Safety and efficacy of tenofovir/emtricitabine plus nevirapine in HIV-infected patients P Labarga, J Medrano, E Seclen, E Poveda, S Rodriguez-Novoa, ... Aids 24 (5), 777-779, 2010 | 16 | 2010 |
Determinants in HIV-2 Env and tetherin required for functional interaction CM Exline, SJ Yang, KG Haworth, S Rengarajan, LA Lopez, ME Droniou, ... Retrovirology 12, 1-13, 2015 | 12 | 2015 |
severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions E Seclén, V Soriano, M del Mar González, J González-Lahoz, E Poveda AIDS research and human retroviruses 27 (9), 965-967, 2011 | 11 | 2011 |
Improvement of genotypic algorithms to predict HIV-1 tropism in treatment-experienced patients-correlation with Trofile results E Poveda, E Seclen, MM Gonzalez, C Garrido, C de Mendoza, R Sanchez, ... Antiviral Therapy 13 (4), A109-A109, 2008 | 6 | 2008 |
Variability in HIV viral tropism determination using different genotypic algorithms in patients infected with B versus non-B HIV-1 subtypes JJ Rodríguez, E Seclen, E Poveda, E Varela, B Regueiro, A Aguilera Enfermedades Infecciosas y Microbiologia Clinica 29 (1), 4-8, 2011 | 5 | 2011 |
Correlation between population based-sequencing and viral tropism determination on PBMC DNA and plasma RNA in comparison with phenotypic methods C Verhofstede, J Reynaerts, E Poveda, E Seclén, S De Wit, K Kabeya, ... | 4 | 2009 |
Dynamics of viral tropism in HIV-infected patients under prolonged HIV-RNA suppression under HAART E Seclén, MM González, V Soriano, E Poveda 7th European HIV Drug Resistance Workshop. Stockholm, 25-27, 2009 | 3 | 2009 |
Increasing HR-mediated genome editing in HSPCs through manipulation of DNA repair proteins D Krasner, N Moatti, C Wang, E Seclen, D Miranda, A Gadon, K Stanten, ... MOLECULAR THERAPY 26 (5), 84-85, 2018 | 2 | 2018 |