The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups C Curtis, SP Shah, SF Chin, G Turashvili, OM Rueda, MJ Dunning, ... Nature 486 (7403), 346-352, 2012 | 6081 | 2012 |
Improved heritability estimation from genome-wide SNPs D Speed, G Hemani, MR Johnson, DJ Balding The American Journal of Human Genetics 91 (6), 1011-1021, 2012 | 723 | 2012 |
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast DC Jeffares, C Jolly, M Hoti, D Speed, L Shaw, C Rallis, F Balloux, ... Nature communications 8 (1), 14061, 2017 | 527 | 2017 |
Reevaluation of SNP heritability in complex human traits D Speed, N Cai, Ucleb Consortium, MR Johnson, S Nejentsev, ... Nature genetics 49 (7), 986-992, 2017 | 449 | 2017 |
Relatedness in the post-genomic era: is it still useful? D Speed, DJ Balding Nature Reviews Genetics 16 (1), 33-44, 2015 | 301 | 2015 |
MultiBLUP: improved SNP-based prediction for complex traits D Speed, DJ Balding Genome research 24 (9), 1550-1557, 2014 | 289 | 2014 |
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies Nature communications 9 (1), 5269, 2018 | 243 | 2018 |
SumHer better estimates the SNP heritability of complex traits from summary statistics D Speed, DJ Balding Nature genetics 51 (2), 277-284, 2019 | 216 | 2019 |
Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data DS Tylee, J Sun, JL Hess, MA Tahir, E Sharma, R Malik, BB Worrall, ... American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177 …, 2018 | 205 | 2018 |
Graph pangenome captures missing heritability and empowers tomato breeding Y Zhou, Z Zhang, Z Bao, H Li, Y Lyu, Y Zan, Y Wu, L Cheng, Y Fang, K Wu, ... Nature 606 (7914), 527-534, 2022 | 183 | 2022 |
The genomic and phenotypic diversity of Schizosaccharomyces pombe DC Jeffares, C Rallis, A Rieux, D Speed, M Převorovský, T Mourier, ... Nature genetics 47 (3), 235-241, 2015 | 177 | 2015 |
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies RJL Anney, A Avbersek, D Balding, L Baum, F Becker, SF Berkovic, ... The Lancet Neurology, 2014 | 170 | 2014 |
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus MR Johnson, J Behmoaras, L Bottolo, ML Krishnan, K Pernhorst, ... Nature communications 6 (1), 6031, 2015 | 157 | 2015 |
Evaluating and improving heritability models using summary statistics D Speed, J Holmes, DJ Balding Nature genetics 52 (4), 458-462, 2020 | 137 | 2020 |
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease MR Johnson, K Shkura, SR Langley, A Delahaye-Duriez, P Srivastava, ... Nature neuroscience 19 (2), 223-232, 2016 | 137 | 2016 |
Comprehensive molecular portraits of human breast tumours C Curtis, SP Shah, SF Chin, G Turashvili, OM Rueda, MJ Dunning, ... Nature 490 (7418), 61-70, 2012 | 129 | 2012 |
Investigating the association between body fat and depression via Mendelian randomization MS Speed, OH Jefsen, AD Børglum, D Speed, SD Østergaard Translational psychiatry 9 (1), 184, 2019 | 124 | 2019 |
Improved genetic prediction of complex traits from individual-level data or summary statistics Q Zhang, F Privé, B Vilhjálmsson, D Speed Nature communications 12 (1), 4192, 2021 | 112 | 2021 |
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI A Couto Alves, NMG De Silva, V Karhunen, U Sovio, S Das, HR Taal, ... Science Advances 5 (9), eaaw3095, 2019 | 111 | 2019 |
Describing the genetic architecture of epilepsy through heritability analysis D Speed, TJ O’Brien, A Palotie, K Shkura, AG Marson, DJ Balding, ... Brain 137 (10), 2680-2689, 2014 | 104 | 2014 |