| Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells L Wu, Q Wei, J Brzostek, NRJ Gascoigne Cellular & Molecular Immunology 17 (6), 600-612, 2020 | 128 | 2020 |
| Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells B Zhang, J Sun, Y Wang, D Ji, Y Yuan, S Li, Y Sun, Y Hou, P Li, L Zhao, ... Nature biomedical engineering 5 (11), 1288-1305, 2021 | 72 | 2021 |
| Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone L Wu, J Chen, Y Wu, B Zhang, X Cai, Z Zhang, Y Wang, LL Si, H Xu, ... Journal of Controlled Release 249, 84-93, 2017 | 52 | 2017 |
| Re‐exploration of the Codon Context Effect on Amber Codon‐Guided Incorporation of Noncanonical Amino Acids in Escherichia coli by the Blue–White Screening … H Xu, Y Wang, J Lu, B Zhang, Z Zhang, L Si, L Wu, T Yao, C Zhang, ... ChemBioChem 17 (13), 1250-1256, 2016 | 39 | 2016 |
| Development of next generation of therapeutic IFN-α2b via genetic code expansion B Zhang, H Xu, J Chen, Y Zheng, Y Wu, L Si, L Wu, C Zhang, G Xia, ... Acta Biomaterialia 19, 100-111, 2015 | 32 | 2015 |
| Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion Y Wu, H Zhu, B Zhang, F Liu, J Chen, Y Wang, Y Wang, Z Zhang, L Wu, ... Bioconjugate Chemistry 27 (10), 2460-2468, 2016 | 30 | 2016 |
| Photoswitchable CAR-T cell function in vitro and in vivo via a cleavable mediator B Zhang, Y Wang, S Huang, J Sun, M Wang, W Ma, Y You, L Wu, J Hu, ... Cell Chemical Biology 28 (1), 60-69. e7, 2021 | 22 | 2021 |
| CRISPRi-manipulation of genetic code expansion via RF1 for reassignment of amber codon in bacteria B Zhang, Q Yang, J Chen, L Wu, T Yao, Y Wu, H Xu, L Zhang, Q Xia, ... Scientific reports 6 (1), 20000, 2016 | 20 | 2016 |
| Targeting CAR to the peptide-MHC complex reveals distinct signaling compared to that of TCR in a jurkat T cell model L Wu, J Brzostek, S Sankaran, Q Wei, J Yap, TYY Tan, J Lai, PA MacAry, ... Cancers 13 (4), 867, 2021 | 19 | 2021 |
| CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance L Wu, J Brzostek, PDS Vale, Q Wei, CKT Koh, JXH Ong, L Wu, JC Tan, ... Cell Reports Medicine 4 (2), 2023 | 17 | 2023 |
| Single molecule force spectroscopy reveals distinctions in key biophysical parameters of αβ T-cell receptors compared with chimeric antigen receptors directed at the same ligand D Banik, M Hamidinia, J Brzostek, L Wu, HM Stephens, PA MacAry, ... The journal of physical chemistry letters 12 (31), 7566-7573, 2021 | 17 | 2021 |
| 856 SNS-101, a highly pH-selective VISTA: PSGL-1 inhibitory antibody, potentiates anti-PD-1 sensitivity, expands memory T-cells and enhances tumor infiltration of CD8 T-cells T Thisted, T Eitas, K Malhotra, Y Kleschenko, F Finley, ZG Jiang, ... Journal for ImmunoTherapy of Cancer 10 (Suppl 2), 2022 | 3 | 2022 |
| 278 CRISPR screen identifies novel regulator for advancing allogeneic CAR-T Therapy KT Clara, L Wu, VJY Tan, PS Vale, NRJ Gascoigne Journal for ImmunoTherapy of Cancer 12 (Suppl 2), 2024 | | 2024 |
| 265 Manipulation of T cell signaling cascades for improved immunotherapy NRJ Gascoigne, L Wu, PS Vale Journal for ImmunoTherapy of Cancer 12 (Suppl 2), 2024 | | 2024 |
| Generation of gene-of-interest double allele knockout clones in primary human T cells by CRISPR L Wu, JC Tan, NRJ Gascoigne STAR protocols 4 (3), 102445, 2023 | | 2023 |
| 274 LCK knockout CAR-T cells as a novel allogeneic platform PDS Vale, L Wu, VJY Tan, B Chua, L Wu, JC Tan, CKT Koh, J Ong, ... Journal for ImmunoTherapy of Cancer 10 (Suppl 2), 2022 | | 2022 |
| 283 Genome-wide CRISPR screens of cytotoxic T cells identify a novel regulator that enhances T cell effector function VJY Tan, L Wu, CKT Koh, YL Chua, L Wu, JXH Ong, N Gascoigne Journal for ImmunoTherapy of Cancer 10 (Suppl 2), 2022 | | 2022 |
| Engineered immune cells L Wu, NRJ Gascoigne, J Brzostek US Patent App. 17/434,186, 2022 | | 2022 |
| Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy NRJ Gascoigne, L Wu, J Brzostek, Q Wei, PDS Vale, CKT Koh, YL Chua, ... The Journal of Immunology 208 (1_Supplement), 122.02-122.02, 2022 | | 2022 |
| LCK-independent chimeric antigen receptor T cell signaling improves specificity and function L Wu, N Gascoigne EUROPEAN JOURNAL OF IMMUNOLOGY 49, 1725-1725, 2019 | | 2019 |
