In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease CH Lau, Y Suh F1000Research, 2017 | 156 | 2017 |
Using artificial microRNA sponges to achieve microRNA loss-of-function in cancer cells FC Tay, JK Lim, H Zhu, CH Lau, S Wang Advanced drug delivery reviews 81, 117-127, 2015 | 154 | 2015 |
Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and … CH Lau, S Muniandy Cardiovascular diabetology 10, 1-18, 2011 | 118 | 2011 |
Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells H Zhu, CH Lau, SL Goh, Q Liang, C Chen, S Du, RZ Phang, FC Tay, ... Nucleic acids research 41 (19), e180-e180, 2013 | 66 | 2013 |
Adiponectin and resistin gene polymorphisms in association with their respective adipokine levels CH Lau, S Muniandy Annals of human genetics 75 (3), 370-382, 2011 | 57 | 2011 |
Dual-function, cationic, peptide-coated nanodiamond systems: facilitating nuclear-targeting delivery for enhanced gene therapy applications HM Leung, MS Chan, LS Liu, SW Wong, TW Lo, CH Lau, C Tin, PK Lo ACS Sustainable Chemistry & Engineering 6 (8), 9671-9681, 2018 | 49 | 2018 |
In vivo epigenome editing and transcriptional modulation using CRISPR technology CH Lau, Y Suh Transgenic Research, 2018 | 48 | 2018 |
Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa CH Lau, WT Ho, PK Lo, C Tin Molecular Therapy - Nucleic Acid, 2019 | 45 | 2019 |
Penetrating the blood–brain barrier by self-assembled 3D DNA nanocages as drug delivery vehicles for brain cancer therapy DY Tam, JWT Ho, MS Chan, CH Lau, TJH Chang, HM Leung, LS Liu, ... ACS applied materials & interfaces 12 (26), 28928-28940, 2020 | 37 | 2020 |
Zinc finger nuclease-expressing baculoviral vectors mediate targeted genome integration of reprogramming factor genes to facilitate the generation of human induced pluripotent … RZ Phang, FC Tay, SL Goh, CH Lau, H Zhu, WK Tan, Q Liang, C Chen, ... Stem cells translational medicine 2 (12), 935-945, 2013 | 34 | 2013 |
Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector‐mediated zinc finger nuclease expression in human‐induced pluripotent stem cells FC Tay, WK Tan, SL Goh, CJA Ramachandra, CH Lau, H Zhu, C Chen, ... The journal of gene medicine 15 (10), 384-395, 2013 | 34 | 2013 |
Synthetic α-l-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy F Wang, LS Liu, CH Lau, TJ Han Chang, DY Tam, HM Leung, C Tin, ... ACS applied materials & interfaces 11 (42), 38510-38518, 2019 | 28 | 2019 |
Applications of CRISPR-Cas in Bioengineering, Biotechnology, and Translational Research CH Lau The CRISPR Journal 1 (6), 379–404, 2018 | 27 | 2018 |
CRISPR-based strategies for targeted transgene knock-in and gene correction CH Lau, C Tin, Y Suh Faculty Reviews 9, 20, 2020 | 23 | 2020 |
Genetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system CH Lau, H Zhu, JCK Tay, Z Li, FC Tay, C Chen, WK Tan, S Du, VK Sia, ... Molecular Therapy-Methods & Clinical Development 1, 2014 | 20 | 2014 |
Genome and epigenome editing in mechanistic studies of human aging and aging-related disease CH Lau, Y Suh Gerontology, 2016 | 17 | 2016 |
Targeted Brain Tumor Imaging by Using Discrete Biopolymer-Coated Nanodiamonds across the Blood Brain Barrier HM Leung, CH Lau, JWT Ho, MS Chan, TJH Chang, LH Law, F Wang, ... Nanoscale, 2021 | 13 | 2021 |
Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides C Cui, CH Lau, LT Chu, HK Kwong, C Tin, TH Chen Biosensors and Bioelectronics 220, 114859, 2023 | 11 | 2023 |
CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control CH Lau, Y Suh Mammalian Genome, 2017 | 9 | 2017 |
Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery F Wang, LS Liu, P Li, CH Lau, HM Leung, YR Chin, C Tin, PK Lo Materials Today Bio 15, 100299, 2022 | 7 | 2022 |