Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 456 | 2019 |
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice P Liu, SQ Liang, C Zheng, E Mintzer, YG Zhao, K Ponnienselvan, A Mir, ... Nature communications 12 (1), 2121, 2021 | 214 | 2021 |
NmeCas9 is an intrinsically high-fidelity genome-editing platform N Amrani, XD Gao, P Liu, A Edraki, A Mir, R Ibraheim, A Gupta, KE Sasaki, ... Genome Biology 19, 1-25, 2018 | 135 | 2018 |
Precise therapeutic gene correction by a simple nuclease-induced double-stranded break S Iyer, S Suresh, D Guo, K Daman, JCJ Chen, P Liu, M Zieger, K Luk, ... Nature 568 (7753), 561-565, 2019 | 115 | 2019 |
Enhanced Cas12a editing in mammalian cells and zebrafish P Liu, K Luk, M Shin, F Idrizi, S Kwok, B Roscoe, E Mintzer, S Suresh, ... Nucleic acids research 47 (8), 4169-4180, 2019 | 107 | 2019 |
Potent Cas9 inhibition in bacterial and human cells by AcrIIC4 and AcrIIC5 anti-CRISPR proteins J Lee, A Mir, A Edraki, B Garcia, N Amrani, HE Lou, I Gainetdinov, ... MBio 9 (6), 10.1128/mbio. 02321-18, 2018 | 94 | 2018 |
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins J Lee, H Mou, R Ibraheim, SQ Liang, P Liu, W Xue, EJ Sontheimer Rna 25 (11), 1421-1431, 2019 | 93 | 2019 |
Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio L Long, H Guo, D Yao, K Xiong, Y Li, P Liu, Z Zhu, D Liu Cell research 25 (5), 638-641, 2015 | 83 | 2015 |
UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans T Shpilka, YG Du, Q Yang, A Melber, N Uma Naresh, J Lavelle, S Kim, ... Nature communications 12 (1), 479, 2021 | 72 | 2021 |
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver C Zheng, SQ Liang, B Liu, P Liu, SY Kwan, SA Wolfe, W Xue Molecular Therapy 30 (3), 1343-1351, 2022 | 68 | 2022 |
Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system P Liu, L Long, K Xiong, B Yu, N Chang, JW Xiong, Z Zhu, D Liu Cell research 24 (7), 886-889, 2014 | 61 | 2014 |
5′-Modifications improve potency and efficacy of DNA donors for precision genome editing KS Ghanta, Z Chen, A Mir, GA Dokshin, PM Krishnamurthy, Y Yoon, ... Elife 10, e72216, 2021 | 52 | 2021 |
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans ND Peterson, HK Cheesman, P Liu, SM Anderson, KJ Foster, R Chhaya, ... PLoS genetics 15 (1), e1007935, 2019 | 51 | 2019 |
Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development KJ Foster, HK Cheesman, P Liu, ND Peterson, SM Anderson, ... Cell reports 31 (1), 2020 | 50 | 2020 |
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria Q Yang, P Liu, NS Anderson, T Shpilka, YG Du, NU Naresh, R Li, LJ Zhu, ... Nature cell biology 24 (2), 181-193, 2022 | 48 | 2022 |
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1 C Statzer, J Meng, R Venz, M Bland, S Robida-Stubbs, K Patel, D Petrovic, ... Nature Communications 13 (1), 967, 2022 | 46 | 2022 |
Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing MF Bolukbasi, P Liu, K Luk, SF Kwok, A Gupta, N Amrani, EJ Sontheimer, ... Nature communications 9 (1), 4856, 2018 | 40 | 2018 |
mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans M Liu, P Liu, L Zhang, Q Cai, G Gao, W Zhang, Z Zhu, D Liu, Q Fan Cell research 21 (11), 1605-1618, 2011 | 40 | 2011 |
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag SQ Liang, P Liu, JL Smith, E Mintzer, S Maitland, X Dong, Q Yang, J Lee, ... Nature communications 13 (1), 437, 2022 | 36 | 2022 |
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector H Zhang, N Bamidele, P Liu, O Ojelabi, XD Gao, T Rodriguez, H Cheng, ... GEN biotechnology 1 (3), 285-299, 2022 | 31 | 2022 |