| A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes SR Wilkinson, MC Taylor, D Horn, JM Kelly, I Cheeseman Proceedings of the National Academy of Sciences 105 (13), 5022-5027, 2008 | 521 | 2008 |
| Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites BS Hall, C Bot, SR Wilkinson Journal of Biological Chemistry 286 (15), 13088-13095, 2011 | 320 | 2011 |
| Trypanocidal drugs: mechanisms, resistance and new targets SR Wilkinson, JM Kelly Expert reviews in molecular medicine 11, e31, 2009 | 303 | 2009 |
| Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation BS Hall, SR Wilkinson Antimicrobial agents and chemotherapy 56 (1), 115-123, 2012 | 262 | 2012 |
| Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-β from Alzheimer disease CJ Sarell, SR Wilkinson, JH Viles Journal of biological chemistry 285 (53), 41533-41540, 2010 | 220 | 2010 |
| Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi SR Wilkinson, NJ Temperton, A Mondragon, JM Kelly Journal of Biological Chemistry 275 (11), 8220-8225, 2000 | 217 | 2000 |
| Spo0A directly controls the switch from acid to solvent production in solvent‐forming clostridia A Ravagnani, KCB Jennert, E Steiner, R Grünberg, JR Jefferies, ... Molecular microbiology 37 (5), 1172-1185, 2000 | 199 | 2000 |
| Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification F Irigoín, L Cibils, MA Comini, SR Wilkinson, L Flohé, R Radi Free Radical Biology and Medicine 45 (6), 733-742, 2008 | 195 | 2008 |
| Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus J Tovar, S Wilkinson, JC Mottram, AH Fairlamb Molecular microbiology 29 (2), 653-660, 1998 | 192 | 1998 |
| Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum SR Wilkinson, SO Obado, IL Mauricio, JM Kelly Proceedings of the National Academy of Sciences 99 (21), 13453-13458, 2002 | 189 | 2002 |
| Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase … L Piacenza, F Irigoín, MN Alvarez, G Peluffo, MC Taylor, JM Kelly, ... Biochemical Journal 403 (2), 323-334, 2007 | 179 | 2007 |
| Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite L Piacenza, G Peluffo, MN Alvarez, JM Kelly, SR Wilkinson, R Radi Biochemical Journal 410 (2), 359-368, 2008 | 175 | 2008 |
| The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin SR Wilkinson, DJ Meyer, MC Taylor, EV Bromley, MA Miles, JM Kelly Journal of Biological Chemistry 277 (19), 17062-17071, 2002 | 171 | 2002 |
| Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population AM Mejia, BS Hall, MC Taylor, A Gómez-Palacio, SR Wilkinson, ... The Journal of infectious diseases 206 (2), 220-228, 2012 | 157 | 2012 |
| Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. SR Wilkinson, C Bot, J Kelly, B Hall Current Topics in Medicinal Chemistry 11, 2072-2084, 2011 | 152 | 2011 |
| RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the African trypanosome SR Wilkinson, D Horn, SR Prathalingam, JM Kelly Journal of Biological Chemistry 278 (34), 31640-31646, 2003 | 143 | 2003 |
| Novel 3-Nitro-1H-1,2,4-triazole-Based Amides and Sulfonamides as Potential Antitrypanosomal Agents MV Papadopoulou, WD Bloomer, HS Rosenzweig, E Chatelain, M Kaiser, ... Journal of medicinal chemistry 55 (11), 5554-5565, 2012 | 122 | 2012 |
| Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei SR Wilkinson, SR Prathalingam, MC Taylor, A Ahmed, D Horn, JM Kelly Free Radical Biology and Medicine 40 (2), 198-209, 2006 | 120 | 2006 |
| Characterization of spo0A homologues in diverse Bacillus and Clostridium species identifies a probable DNA‐binding domain DP Brown, L Ganova‐Raeva, BD Green, SR Wilkinson, M Young, ... Molecular microbiology 14 (3), 411-426, 1994 | 103 | 1994 |
| TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the … SR Wilkinson, MC Taylor, S Touitha, IL Mauricio, DJ Meyer, JM Kelly Biochemical Journal 364 (3), 787-794, 2002 | 99 | 2002 |
