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Hai-Tsang Huang
Hai-Tsang Huang
Research Scientist, Broad Institute
在 broadinstitute.org 的电子邮件经过验证
标题
引用次数
引用次数
年份
A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader
HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ...
Cell chemical biology 25 (1), 88-99. e6, 2018
4232018
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
elife 8, e45457, 2019
2452019
NUAK2 is a critical YAP target in liver cancer
WC Yuan, B Pepe-Mooney, GG Galli, MT Dill, HT Huang, M Hao, Y Wang, ...
Nature communications 9 (1), 4834, 2018
1222018
MELK is not necessary for the proliferation of basal-like breast cancer cells
HT Huang, HS Seo, T Zhang, Y Wang, B Jiang, Q Li, DL Buckley, B Nabet, ...
Elife 6, e26693, 2017
1152017
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
S Banerjee, SJ Buhrlage, HT Huang, X Deng, W Zhou, J Wang, R Traynor, ...
Biochemical Journal 457 (1), 215-225, 2014
832014
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival
Y Wang, M Begley, Q Li, HT Huang, A Lako, MJ Eck, NS Gray, ...
Proceedings of the National Academy of Sciences 113 (35), 9810-9815, 2016
752016
An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes
HT Huang, TC Lacy, B Błachut, GX Ortiz Jr, Q Wang
Organic letters 15 (8), 1818-1821, 2013
722013
Synergistic interactions with PI3K inhibition that induce apoptosis
Y Zwang, O Jonas, C Chen, ML Rinne, JG Doench, F Piccioni, L Tan, ...
elife 6, e24523, 2017
322017
Stable isotope labeling strategy for protein–ligand binding analysis in multi-component protein mixtures
PD DeArmond, GM West, HT Huang, MC Fitzgerald
Journal of the American Society for Mass Spectrometry 22 (3), 418-430, 2011
222011
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
HT Huang, RJ Lumpkin, RW Tsai, S Su, X Zhao, Y Xiong, J Chen, ...
Nature Chemical Biology, 1-10, 2024
132024
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife 8
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
102019
Tricyclic kinase inhibitors of MELK and methods of use
N Gray, T Zhang, HT Huang, Y Wang, J Zhao, HG Choi
US Patent 10,544,138, 2020
82020
NUAK2 is a critical YAP target in liver cancer. Nat. Commun. 9, 4834
WC Yuan, B Pepe-Mooney, GG Galli, MT Dill, HT Huang, M Hao, Y Wang, ...
62018
Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
NS Gray, D Dobrovolsky, HT Huang
US Patent 10,925,967, 2021
32021
Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
NS Gray, D Dobrovolsky, HT Huang
US Patent 10,842,878, 2020
22020
Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
NS Gray, D Dobrovolsky, HT Huang
US Patent 11,730,818, 2023
12023
A ubiquitin-specific proximity labeling method to study drug-induced ubiquitylation
HT Huang, RJ Lumpkin, RW Tsai, KA Donovan, S Su, X Zhao, J Chen, ...
Cancer Research 84 (6_Supplement), 3885-3885, 2024
2024
Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
NS Gray, D Dobrovolsky, HT Huang
US Patent App. 18/214,825, 2023
2023
Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use
NS Gray, J Bradner, L Tan, HT Huang, D Buckley, G Winter, ...
US Patent 10,925,868, 2021
2021
Salicylate inhibitors of MELK and methods of use
N Gray, T Zhang, HT Huang, Y Wang, J Zhao, HG Choi
US Patent 10,875,844, 2020
2020
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