| Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection JB Towle-Weicksel, S Dalal, CD Sohl, S Doublié, KS Anderson, ... Journal of Biological Chemistry 289 (23), 16541-16550, 2014 | 35 | 2014 |
| The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection BE Eckenroth, JB Towle-Weicksel, JB Sweasy, S Doublié Journal of Biological Chemistry 288 (48), 34850-34860, 2013 | 23 | 2013 |
| I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity C Liptak, MM Mahmoud, BE Eckenroth, MV Moreno, K East, KS Alnajjar, ... Nucleic acids research 46 (20), 10740-10756, 2018 | 21 | 2018 |
| Defective nucleotide release by DNA polymerase β mutator variant E288K is the basis of its low fidelity MM Mahmoud, A Schechter, KS Alnajjar, J Huang, J Towle-Weicksel, ... Biochemistry 56 (41), 5550-5559, 2017 | 18 | 2017 |
| Remote mutations induce functional changes in active site residues of human DNA polymerase β BE Eckenroth, JB Towle-Weicksel, AA Nemec, DL Murphy, JB Sweasy, ... Biochemistry 56 (18), 2363-2371, 2017 | 13 | 2017 |
| Estrogen drives cellular transformation and mutagenesis in cells expressing the breast cancer–associated R438W DNA polymerase lambda protein AA Nemec, KB Bush, JB Towle-Weicksel, BF Taylor, V Schulz, ... Molecular Cancer Research 14 (11), 1068-1077, 2016 | 13 | 2016 |
| Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes C Fijen, MM Mahmoud, M Kronenberg, R Kaup, M Fontana, ... Journal of Biological Chemistry 295 (27), 9012-9020, 2020 | 5 | 2020 |
| Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity C Thomas, L Avalos-Irving, J Victorino, S Green, M Andrews, N Rodrigues, ... Biochemistry 63 (9), 1107-1117, 2024 | 1 | 2024 |
| Zebrafish Polymerase Theta and human Polymerase Theta: orthologues with homologous function C Thomas, S Green, L Kimball, IR Schmidtke, M Griffin, L Rothwell, I Par, ... bioRxiv, 2024 | | 2024 |
| Elucidating the Active Site Environment and Mechanism of a Cancer-Associated Variant of DNA Polymerase Theta S Green, M Andrews, J Towle-Weicksel PROTEIN SCIENCE 32 (12), 2023 | | 2023 |
| Research at a PUI: Elucidating the Mechanism of DNA Pol Theta in Cancer J Towle-Weicksel PROTEIN SCIENCE 32 (12), 2023 | | 2023 |
| Melanoma-Derived L2538R Human DNA Polymerase theta Variant Exhibits Decreased DNA Polymerase Function M Andrews, C Thomas, LA Valiente, J Victorino, J Towle-Weicksel PROTEIN SCIENCE 30, 189-190, 2021 | | 2021 |
| Characterizing the role of POLQ variants in genomic instability and cancer S Ray, F Sheld, A Moen, L Avalos, J Victorino, J Towle-Weicksel The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |
| Cancer‐associated variants of POLQ induce genomic instability A Headrick, S Wanchu, L Avalos, J Victorino, J Towle‐Weicksel, S Ray The FASEB Journal 33 (S1), 457.7-457.7, 2019 | | 2019 |
| DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint C Fijen, M Mahmoud, R Kaup, J Towle-Weicksel, J Sweasy, J Hohlbein bioRxiv, 306175, 2018 | | 2018 |
| FRET Studies of DNA Polβ Mutator I260Q: The Critical Role of Fingers Domain Movements and Nucleotide Selection J Towle‐Weicksel, B Eckenroth, M Moreno, S Doublié, J Sweasy The FASEB Journal 29, 879.14, 2015 | | 2015 |
| DNA polymerase β fingers movement revealed by smFRET suggests a partially closed conformation as a fidelity checkpoint C Fijen, M Mahmoud, R Kaup, J Towle-Weicksel, J Sweasy, J Hohlbein DNA polymerases at work: single-molecule observations of DNA synthesis in …, 0 | | |
