| Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex JCK Ngo, M Huang, DA Roth, BC Furie, B Furie Structure 16 (4), 597-606, 2008 | 294 | 2008 |
| Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2 JCK Ngo, S Chakrabarti, JH Ding, A Velazquez-Dones, B Nolen, ... Molecular cell 20 (1), 77-89, 2005 | 258 | 2005 |
| Processive phosphorylation of alternative splicing factor/splicing factor 2 BE Aubol, S Chakrabarti, J Ngo, J Shaffer, B Nolen, XD Fu, G Ghosh, ... Proceedings of the National Academy of Sciences 100 (22), 12601-12606, 2003 | 147 | 2003 |
| A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1 JCK Ngo, K Giang, S Chakrabarti, CT Ma, N Huynh, JC Hagopian, ... Molecular cell 29 (5), 563-576, 2008 | 132 | 2008 |
| SRPKIN-1: a covalent SRPK1/2 inhibitor that potently converts VEGF from pro-angiogenic to anti-angiogenic isoform JM Hatcher, G Wu, C Zeng, J Zhu, F Meng, S Patel, W Wang, SB Ficarro, ... Cell chemical biology 25 (4), 460-470. e6, 2018 | 118 | 2018 |
| A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia H Tsoi, CS Allen, ZS Chen, NKN Ng, AYY Chan, LYP Yuen, JM Abrigo, ... Journal of Medical Genetics 51 (9), 590-595, 2014 | 87 | 2014 |
| Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1 C Yuan, L Chen, EJ Meehan, N Daly, DJ Craik, M Huang, JC Ngo BMC structural biology 11, 1-10, 2011 | 71 | 2011 |
| Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1 JC Hagopian, CT Ma, BR Meade, CP Albuquerque, JCK Ngo, G Ghosh, ... Journal of molecular biology 382 (4), 894-909, 2008 | 68 | 2008 |
| SR protein kinase 1 is resilient to inactivation JCK Ngo, J Gullingsrud, K Giang, MJ Yeh, XD Fu, JA Adams, ... Structure 15 (1), 123-133, 2007 | 52 | 2007 |
| Structural basis for therapeutic intervention of uPA/uPAR system J Chi Ki Ngo, L Jiang, Z Lin, C Yuan, Z Chen, X Zhang, H Yu, J Wang, ... Current drug targets 12 (12), 1729-1743, 2011 | 50 | 2011 |
| Distinct mechanisms govern the phosphorylation of different SR protein splicing factors Y Long, WH Sou, KWY Yung, H Liu, SWC Wan, Q Li, C Zeng, COK Law, ... Journal of Biological Chemistry 294 (4), 1312-1327, 2019 | 49 | 2019 |
| Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis KKK Wong, JCK Ngo, S Liu, H Lin, C Hu, PC Shaw, DCC Wan Chemico-biological interactions 187 (1-3), 335-339, 2010 | 47 | 2010 |
| Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1 B Zhao, C Yuan, R Li, D Qu, M Huang, JCK Ngo Journal of Biological Chemistry 288 (16), 11155-11164, 2013 | 44 | 2013 |
| A camelid-derived antibody fragment targeting the active site of a serine protease balances between inhibitor and substrate behavior T Kromann-Hansen, E Oldenburg, KWY Yung, GH Ghassabeh, ... Journal of Biological Chemistry 291 (29), 15156-15168, 2016 | 41 | 2016 |
| Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing WNV Chow, JCK Ngo, W Li, YW Chen, KMV Tam, HYE Chan, CCJ Miller, ... Biochemical Journal 470 (3), 303-317, 2015 | 36 | 2015 |
| Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography B Nolen, J Ngo, S Chakrabarti, D Vu, JA Adams, G Ghosh Biochemistry 42 (32), 9575-9585, 2003 | 31 | 2003 |
| Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1 W Li, KMV Tam, WWR Chan, AC Koon, JCK Ngo, HYE Chan, KF Lau Journal of Biological Chemistry 293 (20), 7674-7688, 2018 | 28 | 2018 |
| A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases Q Zhang, ZS Chen, Y An, H Liu, Y Hou, W Li, KF Lau, AC Koon, JCK Ngo, ... RNA 24 (4), 486-498, 2018 | 27 | 2018 |
| Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models ZS Chen, L Li, S Peng, FM Chen, Q Zhang, Y An, X Lin, W Li, AC Koon, ... EMBO reports 19 (9), e45409, 2018 | 25 | 2018 |
| CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration S Peng, P Guo, X Lin, Y An, KH Sze, MHY Lau, ZS Chen, Q Wang, W Li, ... Proceedings of the National Academy of Sciences 118 (19), e2022940118, 2021 | 22 | 2021 |
