| Impact of dynamically exposed polarity on permeability and solubility of chameleonic drugs beyond the rule of 5 M Rossi Sebastiano, BC Doak, M Backlund, V Poongavanam, B Over, ... Journal of medicinal chemistry 61 (9), 4189-4202, 2018 | 201 | 2018 |
| Targeting long chain acyl-CoA synthetases for cancer therapy M Rossi Sebastiano, G Konstantinidou International journal of molecular sciences 20 (15), 3624, 2019 | 113 | 2019 |
| Designing soluble PROTACs: strategies and preliminary guidelines D García Jiménez, M Rossi Sebastiano, M Vallaro, V Mileo, D Pizzirani, ... Journal of Medicinal Chemistry 65 (19), 12639-12649, 2022 | 52 | 2022 |
| The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer M Saliakoura, I Reynoso-Moreno, C Pozzato, M Rossi Sebastiano, ... Oncogene 39 (14), 2948-2960, 2020 | 45 | 2020 |
| ACSL3–PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression M Rossi Sebastiano, C Pozzato, M Saliakoura, Z Yang, RW Peng, M Galiè, ... Science advances 6 (44), eabb9200, 2020 | 44 | 2020 |
| Rational control of molecular properties is mandatory to exploit the potential of PROTACs as oral drugs G Ermondi, D Garcia Jimenez, M Rossi Sebastiano, G Caron ACS Medicinal Chemistry Letters 12 (7), 1056-1060, 2021 | 32 | 2021 |
| Macrocyclic peptides uncover a novel binding mode for reversible inhibitors of LSD1 J Yang, VO Talibov, S Peintner, C Rhee, V Poongavanam, M Geitmann, ... ACS omega 5 (8), 3979-3995, 2020 | 22 | 2020 |
| AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin MR Sebastiano, G Ermondi, S Hadano, G Caron Drug Discovery Today 27 (6), 1652-1660, 2022 | 21 | 2022 |
| PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia M Saliakoura, M Rossi Sebastiano, C Pozzato, FH Heidel, TM Schnöder, ... Nature cell biology 22 (11), 1382-1395, 2020 | 21 | 2020 |
| Chamelogk: A chromatographic Chameleonicity quantifier to design orally bioavailable beyond-rule-of-5 drugs D Garcia Jimenez, M Vallaro, M Rossi Sebastiano, G Apprato, ... Journal of Medicinal Chemistry 66 (15), 10681-10693, 2023 | 16 | 2023 |
| Refinement of computational access to molecular physicochemical properties: From Ro5 to bRo5 M Rossi Sebastiano, D Garcia Jimenez, M Vallaro, G Caron, G Ermondi Journal of Medicinal Chemistry 65 (18), 12068-12083, 2022 | 15 | 2022 |
| Conformational sampling deciphers the chameleonic properties of a VHL-based degrader G Ermondi, DG Jimenez, M Rossi Sebastiano, J Kihlberg, G Caron Pharmaceutics 15 (1), 272, 2023 | 14 | 2023 |
| Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy M Saliakoura, MR Sebastiano, I Nikdima, C Pozzato, G Konstantinidou Journal of Experimental & Clinical Cancer Research 41 (1), 16, 2022 | 12 | 2022 |
| Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype SM Hiatt, S Trajkova, MR Sebastiano, EC Partridge, FE Abidi, A Anderson, ... The American Journal of Human Genetics 110 (2), 215-227, 2023 | 9 | 2023 |
| Modeling ErbB2-p130Cas interaction to design new potential anticancer agents A Costamagna, M Rossi Sebastiano, D Natalini, M Simoni, G Valabrega, ... Scientific reports 9 (1), 3089, 2019 | 7 | 2019 |
| DegraderTCM: A Computationally Sparing Approach for Predicting Ternary Degradation Complexes P Rossetti, G Apprato, G Caron, G Ermondi, M Rossi Sebastiano ACS Medicinal Chemistry Letters 15 (1), 45-53, 2023 | 4 | 2023 |
| Spinocerebellar ataxia 38: structure–function analysis shows ELOVL5 G230V is proteotoxic, conformationally altered and a mutational hotspot E Ferrero, E Di Gregorio, M Ferrero, E Ortolan, YA Moon, A Di Campli, ... Human Genetics 142 (8), 1055-1076, 2023 | 3 | 2023 |
| IMHB-Mediated Chameleonicity in Drug Design: A Focus on Structurally Related PROTACs D Garcia Jimenez, M Rossi Sebastiano, M Vallaro, G Ermondi, G Caron Journal of Medicinal Chemistry 67 (13), 11421-11434, 2024 | 2 | 2024 |
| DNA methylation analysis in patients with neurodevelopmental disorders improves variant interpretation and reveals complexity S Trajkova, J Kerkhof, MR Sebastiano, L Pavinato, E Ferrero, C Giovenino, ... Human Genetics and Genomics Advances 5 (3), 2024 | 1 | 2024 |
| Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies M Rossi Sebastiano, G Ermondi, K Sato, A Otomo, S Hadano, G Caron Molecules 27 (20), 7063, 2022 | 1 | 2022 |
