| Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ... Nature biotechnology 34 (2), 184-191, 2016 | 3881 | 2016 |
| HIV: cell binding and entry CB Wilen, JC Tilton, RW Doms Cold Spring Harbor perspectives in medicine 2 (8), a006866, 2012 | 1007 | 2012 |
| Neuroinvasion of SARS-CoV-2 in human and mouse brain E Song, C Zhang, B Israelow, A Lu-Culligan, AV Prado, S Skriabine, P Lu, ... Journal of Experimental Medicine 218 (3), e20202135, 2021 | 950 | 2021 |
| Phenotypic properties of transmitted founder HIV-1 NF Parrish, F Gao, H Li, EE Giorgi, HJ Barbian, EH Parrish, L Zajic, ... Proceedings of the National Academy of Sciences 110 (17), 6626-6633, 2013 | 491 | 2013 |
| Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection J Wei, MM Alfajaro, PC DeWeirdt, RE Hanna, WJ Lu-Culligan, WL Cai, ... Cell 184 (1), 76-91. e13, 2021 | 453 | 2021 |
| Altered virome and bacterial microbiome in human immunodeficiency virus-associated acquired immunodeficiency syndrome CL Monaco, DB Gootenberg, G Zhao, SA Handley, MS Ghebremichael, ... Cell host & microbe 19 (3), 311-322, 2016 | 415 | 2016 |
| Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling B Israelow, E Song, T Mao, P Lu, A Meir, F Liu, MM Alfajaro, J Wei, ... Journal of Experimental Medicine 217 (12), e20201241, 2020 | 409 | 2020 |
| Inflammasome activation in infected macrophages drives COVID-19 pathology E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao, JR Brewer, A Han, ... Nature 606 (7914), 585-593, 2022 | 361 | 2022 |
| Discovery of a proteinaceous cellular receptor for a norovirus RC Orchard, CB Wilen, JG Doench, MT Baldridge, BT McCune, YCJ Lee, ... Science 353 (6302), 933-936, 2016 | 281 | 2016 |
| Molecular mechanisms of HIV entry CB Wilen, JC Tilton, RW Doms Viral molecular machines, 223-242, 2011 | 281 | 2011 |
| Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes NG Ravindra, MM Alfajaro, V Gasque, NC Huston, H Wan, K Szigeti-Buck, ... PLoS biology 19 (3), e3001143, 2021 | 266* | 2021 |
| Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms NC Huston, H Wan, MS Strine, RCA Tavares, CB Wilen, AM Pyle Molecular cell 81 (3), 584-598. e5, 2021 | 234 | 2021 |
| Tropism for tuft cells determines immune promotion of norovirus pathogenesis CB Wilen, S Lee, LL Hsieh, RC Orchard, C Desai, BL Hykes Jr, ... Science 360 (6385), 204-208, 2018 | 208 | 2018 |
| Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity JR Brestoff, CB Wilen, JR Moley, Y Li, W Zou, NP Malvin, MN Rowen, ... Cell metabolism 33 (2), 270-282. e8, 2021 | 205 | 2021 |
| Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection CA Didigu, CB Wilen, J Wang, J Duong, AJ Secreto, GA Danet-Desnoyers, ... Blood, The Journal of the American Society of Hematology 123 (1), 61-69, 2014 | 200 | 2014 |
| De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report S Gandhi, J Klein, AJ Robertson, MA Peña-Hernández, MJ Lin, ... Nature communications 13 (1), 1547, 2022 | 198 | 2022 |
| Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 NF Parrish, CB Wilen, LB Banks, SS Iyer, JM Pfaff, JF Salazar-Gonzalez, ... PLoS pathogens 8 (5), e1002686, 2012 | 192 | 2012 |
| Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases CB Wilen, J Wang, JC Tilton, JC Miller, KA Kim, EJ Rebar, SA Sherrill-Mix, ... PLoS pathogens 7 (4), e1002020, 2011 | 179 | 2011 |
| Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu, SP Anand, ... Immunity 54 (9), 2143-2158. e15, 2021 | 175 | 2021 |
| Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins CB Wilen, NF Parrish, JM Pfaff, JM Decker, EA Henning, H Haim, ... Journal of virology 85 (17), 8514-8527, 2011 | 163 | 2011 |
Herbert W. VirginWashington University School of Medicine在 wustl.edu 的电子邮件经过验证
